Program in Translational and Experimental Hematology

描述(申请人提供)：良性和恶性血液疾病在美国造成了主要的发病率和死亡率，由于美国人口的快速老龄化，发病率正在上升。有效的治疗方法很少，部分原因是受过血液学研究培训的内科科学家和博士科学家数量不足。这项拟议的培训计划将通过支持基础科学或血液学转化研究方面的科学家培训来解决这一重要问题。我们设计了一个培训计划，有严格的研究机会和教职员工的密切指导。我们已经组建了一个杰出的血液学专家小组，作为计划学院来指导研究员的研究工作。学员将在成人血液学临床培训后或通过竞争程序直接从方案学院的实验室进入T32培训计划。对转化研究感兴趣的内科科学家将可以选择攻读临床流行病学硕士学位，以获得临床试验设计方面的技能。T32计划的成员将接受血液学研究的三个广泛领域的培训：造血和干细胞生物学；血栓和血管生物学；免疫学和免疫疗法。培训计划的研究为期两年，将通过授课讲座、出色的研讨会系列和丰富的科学环境来加强。翻译和实验血液学培训计划的成功实施将带来新的生物学见解、新的预防手段和血液疾病的新疗法，为未来的内科科学家研究人员在血液学研究中的职业生涯做好准备。

DESCRIPTION (provided by applicant): Benign and malignant blood diseases cause major morbidity and mortality in the US and are rising in prevalence due to the rapid aging of the American population. Effective therapies are rare in part because of an insufficient number of physician-scientists and PhD scientists trained in Hematology research. This proposed Training Program will address this important problem by supporting the training of scientists in basic science or translational research in Hematology. We have designed a Training Program with rigorous research opportunities and close mentoring by faculty. We have assembled an outstanding panel of leading experts in Hematology as Program Faculty to direct fellows in their research endeavors. Fellows will enter the T32 Training Program after clinical training in adult Hematology or directly from the laboratories of Program Faculty through a competitive process. Physician-scientists interested in translational research will have the option of pursuing a Master's Degree in Clinical Epidemiology to acquire skills in the design of clinical trials. Fellow in the T32 Program will receive training in three broad areas of hematology research: hematopoiesis and stem cell biology; thrombosis and vascular biology; and immunology and immunotherapy. Research in the Training Program comprises two years and will be enhanced by didactic lectures, outstanding seminar series and a rich scientific environment. Successful implementation of this Training Program in Translational and Experimental Hematology will lead to new biological insights, novel means of prevention and new therapies for blood disorders by preparing future physician-scientist investigators for careers in research in Hematology.