Program in Translational and Experimental Hematology

描述（由申请人提供）：良性和恶性血液疾病在美国引起主要的发病率和死亡率，并且由于美国人口的快速老龄化，其患病率正在上升。有效的治疗方法很少，部分原因是在血液学研究方面接受过培训的医生科学家和博士科学家数量不足。这项拟议的培训计划将通过支持血液学基础科学或转化研究科学家的培训来解决这一重要问题。我们设计了一个培训计划，提供严格的研究机会和教师的密切指导。我们已经组建了一个杰出的血液学专家小组，作为项目教师，指导研究员进行研究工作。研究员将在成人血液学临床培训后进入T32培训计划，或通过竞争过程直接从计划学院的实验室进入。对转化研究感兴趣的医生科学家将可以选择攻读临床流行病学硕士学位，以获得临床试验设计方面的技能。T32计划的研究员将接受血液学研究三大领域的培训：造血和干细胞生物学;血栓形成和血管生物学;免疫学和免疫治疗。培训计划的研究为期两年，将通过教学讲座，优秀的研讨会系列和丰富的科学环境来加强。在转化和实验血液学培训计划的成功实施将导致新的生物学见解，预防和血液疾病的新疗法的新手段，通过准备未来的医生科学家研究人员在血液学研究的职业生涯。

DESCRIPTION (provided by applicant): Benign and malignant blood diseases cause major morbidity and mortality in the US and are rising in prevalence due to the rapid aging of the American population. Effective therapies are rare in part because of an insufficient number of physician-scientists and PhD scientists trained in Hematology research. This proposed Training Program will address this important problem by supporting the training of scientists in basic science or translational research in Hematology. We have designed a Training Program with rigorous research opportunities and close mentoring by faculty. We have assembled an outstanding panel of leading experts in Hematology as Program Faculty to direct fellows in their research endeavors. Fellows will enter the T32 Training Program after clinical training in adult Hematology or directly from the laboratories of Program Faculty through a competitive process. Physician-scientists interested in translational research will have the option of pursuing a Master's Degree in Clinical Epidemiology to acquire skills in the design of clinical trials. Fellow in the T32 Program will receive training in three broad areas of hematology research: hematopoiesis and stem cell biology; thrombosis and vascular biology; and immunology and immunotherapy. Research in the Training Program comprises two years and will be enhanced by didactic lectures, outstanding seminar series and a rich scientific environment. Successful implementation of this Training Program in Translational and Experimental Hematology will lead to new biological insights, novel means of prevention and new therapies for blood disorders by preparing future physician-scientist investigators for careers in research in Hematology.