Chicago Prevention and Intervention Epicenter II (CPIE-II)

芝加哥预防和干预震中 II (CPIE-II)

• 批准号: 9338037
• 负责人: Mary Katherine Hayden
• 金额: $ 49.88万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9338037
• 关键词: Chicago; Prevention; Intervention; Epicenter; II

C-PIE II ABSTRACT Multidrug-resistant organisms (MDROs) are increasingly common causes of healthcare-associated infections (HAIs), complicating treatment and leading to increased morbidity, mortality and cost. The Chicago Prevention and Epicenter II (C-PIE II) has developed a portfolio of research projects to study the epidemiology and prevention of key HAI problems, i.e. those caused by MDROs, from the level of individual intensive care units to entire healthcare facilities (long-term acute care hospitals) to the region (Chicago, the third largest city in the nation) and to the state (Illinois, population 13 million). Our proposals range from investigations to improve basic infection control interventions that we have pioneered, such as chlorhexidine gluconate (CHG) bathing, to research that employs the most advanced molecular diagnostic techniques, e.g. bacterial whole genome sequencing and microbiome analysis, and cutting-edge informatics and analytic methods, such as automated alerts and social network analysis. We will conduct our work within a sophisticated existing infrastructure of strong collaborative public health and academic partnerships. These proposed activities comprise our Core Project and Multicenter Collaborative Project proposals. Core Project: We will continue to evaluate novel methods to study the epidemiology and control of carbapenem-resistant Enterobacteriaceae, to optimize antimicrobial stewardship interventions through ethnographic evaluation, and to assess the effect of alternative nasal decolonization strategies on the susceptibility of methicillin-resistant Staphylococcus aureus to antibiotics and antiseptics. The likelihood of success of our investigations is increased by our plan to use a coordinated, collaborative approach across many healthcare facility types, public health agencies, and academic institutions. Multicenter Projects: We propose a Large-sized Collaborative Project (MAriMbA) that will test the hypothesis that specific host factors, clinical care exposures, and gut microbiota alterations are associated with an increased risk of colonization by enteric MDROs. We propose a Medium-sized Collaborative Project (DataMAP-AU) to promote an infrastructure that can be expanded nationally to facilitate and standardize antimicrobial use metrics that are most informative for antimicrobial stewardship interventions. We propose a Small Collaborative Project (CHECkuP) to better understand the optimal use of CHG skin antisepsis to reduce patient colonization by MDROs. In total, we expect our work to fill critical gaps in knowledge related to the epidemiology and prevention of HAIs caused by MDROs, and to advance the science of infection prevention.

C-PIE II摘要 多重耐药微生物（MDRO）是医疗保健相关疾病的常见原因。 感染（HAI），使治疗变得复杂，并导致发病率、死亡率和成本增加。的 芝加哥预防和Epicenter II（C-PIE II）开发了一系列研究项目， 流行病学和从个人层面预防主要HAI问题，即由MDRO引起的问题 重症监护病房到整个医疗机构（长期急性护理医院）到该地区（芝加哥， 美国第三大城市）和州（伊利诺斯州，人口1300万）。我们的建议包括 调查，以改善我们率先采取的基本感染控制干预措施， 葡萄糖酸氯己定（CHG）洗澡，研究采用最先进的分子诊断 技术，例如细菌全基因组测序和微生物组分析，以及尖端的 信息学和分析方法，如自动警报和社交网络分析。我们会进行 我们的工作在一个先进的现有基础设施的强大的合作公共卫生和学术 伙伴关系。这些建议的活动包括我们的核心项目和多中心合作项目 提案 核心项目：我们将继续评估新的方法来研究流行病学和控制 碳青霉烯类耐药肠杆菌科，以优化抗菌管理干预措施， 人种学评价，并评估替代鼻去殖民化策略对 耐甲氧西林金黄色葡萄球菌对抗生素和防腐剂敏感性的可能性 我们的调查的成功是通过我们的计划，以使用一个协调，合作的方法， 许多医疗机构类型、公共卫生机构和学术机构。 多中心项目：我们提出了一个大型合作项目（MAriMbA），将测试 假设特定宿主因素、临床护理暴露和肠道微生物群改变相关 肠道MDRO定植的风险增加。我们提出了一个中型合作 项目（DataMAP-AU），以促进可在全国范围内扩大的基础设施， 标准化抗菌药物使用指标，这些指标对抗菌药物管理干预提供最多信息。 我们提出了一个小型合作项目（KikuP），以更好地了解CHG皮肤的最佳使用 抗菌以减少MDRO对患者的定植。总的来说，我们希望我们的工作能够填补以下方面的关键空白： 与MDRO引起的HAI的流行病学和预防相关的知识，并促进 预防感染的科学。