CK20-004, Chicago Prevention and Intervention Epicenter III (CPIE-III)

核心项目摘要 芝加哥预防和干预中心将专注于疾控中心推动的目标。通过我们的 我们将进行流行病学和基础科学发现和技术创新的核心项目 可转化为防止抗菌素耐药性生物在设施内和区域内传播的战略 跨越互联设施的网络。控制地方性耐药病原体，并 缓解新出现的抗药性机制，需要一系列干预措施，并在 医疗保健设施的范围。我们提出了一个雄心勃勃的医院项目组合，长期急性 护理医院(LTACH)和熟练护理设施。我们的项目跨越了以下感染控制领域 对疾病预防控制中心的兴趣，以以下六个核心项目为注解(本摘要略有删节)： 项目1：预测建模以识别MDRO的高危患者，以通知伊利诺伊州的XDRO登记。 人口、医院和LTACH患者。领域、区域控制，包括长期护理设施。 项目2：通过基因组分析进行区域积极的MDRO监测。人口、医院、LTACH和 养老院。领域，遏制新的抗性。 项目3：社区相关ESBL生产者的地理空间、生态和临床风险因素。 人口、急诊科和两个大型城市卫生系统的门诊病人。域名， 社区相关的抗菌素耐药性感染。 项目4：重症监护室中MDRO传播的基因组流行病学。人群中，医院ICU患者。域名， 应用创新的研究方法评估MDRO传播。 项目5：与微生物区系破坏有关的不良健康后果。人口，内科ICU患者。 微生物组的领域、抗生素使用的影响和诊断评估措施。 项目6：根据国家通用数据模型生成和输出关于抗菌剂使用指标的报告。 人口，医院的病人。领域，抗菌管理

Core Project Summary The Chicago Prevention and Intervention Epicenter will focus on objectives promoted by CDC. Through our core projects we will make epidemiologic and basic science discoveries and technological innovations translatable into strategies to prevent spread of antimicrobial-resistant organisms within facilities and regionally across the web of interconnected facilities. To control endemic antimicrobial-resistant pathogens, and to mitigate emerging, novel mechanisms of resistance, a bundle of interventions is needed and applied across the spectrum of healthcare facilities. We propose an ambitious portfolio of projects in hospitals, long-term acute care hospitals (LTACHs), and skilled nursing facilities. Our projects span the infection control domains of interest to CDC, annotated by the following six core projects (abridged for this summary): Project 1: Predictive modeling to identify patients at high-risk for MDROs to inform Illinois' XDRO registry. Population, hospital and LTACH patients. Domain, regional control including long-term care facilities. Project 2: Regional active MDRO surveillance with genomic analysis. Population, hospitals, LTACHs and nursing homes. Domain, containment of novel resistance. Project 3: Geospatial, ecologic, and clinical risk factors for community-associated ESBL-producers. Population, emergency department and ambulatory patients of two large, urban health systems. Domain, community-associated antimicrobial-resistant infections. Project 4: Genomic epidemiology of MDRO transmission in ICUs. Population, hospital ICU patients. Domain, applying innovative research methodology to evaluate MDRO transmission. Project 5: Adverse health outcomes associated with microbiota disruption. Population, medical ICU patients. Domains, effects of antibiotic use and diagnostics—evaluating measures of the microbiome. Project 6: Generate and export reports on antimicrobial use metrics from a national common data model. Population, hospital patients. Domain, Antimicrobial stewardship