CK20-004, Chicago Prevention and Intervention Epicenter III (CPIE-III)

核心项目摘要 芝加哥预防和干预中心将重点关注疾病预防控制中心推动的目标。通过我们 核心项目，我们将使流行病学和基础科学的发现和技术创新 可转化为战略，以防止耐抗生素生物体在设施内和区域内传播 在互联设施的网络上。控制地方性耐抗生素病原体， 为了缓解新出现的新的耐药机制，需要采取一系列干预措施， 医疗保健设施的范围。我们提出了一个雄心勃勃的项目组合，在医院，长期急性 护理医院（LTACH）和专业护理机构。我们的项目涵盖以下感染控制领域： 以下六个核心项目（本摘要节略）说明了疾病预防控制中心的兴趣： 项目1：预测建模，以确定MDRO的高风险患者，以通知伊利诺伊州的XDRO登记。 人口、医院和LACH患者。领域、区域控制，包括长期护理设施。 项目2：通过基因组分析进行区域主动MDRO监测。人口、医院、长期和 养老院域，遏制新阻力。 项目3：社区相关ESBL生产者的地理空间，生态和临床风险因素。 两个大型城市卫生系统的人口、急诊科和门诊病人。域， 社区相关的耐药性感染。 项目4：ICU中MDRO传播的基因组流行病学。人口，医院ICU患者。域， 应用创新的研究方法来评估MDRO的传播。 项目5：与微生物群破坏相关的不良健康后果。人口，重症监护室的病人。 领域，抗生素使用的影响和微生物组的诊断评估措施。 项目6：根据国家通用数据模型生成和输出抗菌剂使用指标报告。 人口，医院病人。领域，抗菌药物管理

Core Project Summary The Chicago Prevention and Intervention Epicenter will focus on objectives promoted by CDC. Through our core projects we will make epidemiologic and basic science discoveries and technological innovations translatable into strategies to prevent spread of antimicrobial-resistant organisms within facilities and regionally across the web of interconnected facilities. To control endemic antimicrobial-resistant pathogens, and to mitigate emerging, novel mechanisms of resistance, a bundle of interventions is needed and applied across the spectrum of healthcare facilities. We propose an ambitious portfolio of projects in hospitals, long-term acute care hospitals (LTACHs), and skilled nursing facilities. Our projects span the infection control domains of interest to CDC, annotated by the following six core projects (abridged for this summary): Project 1: Predictive modeling to identify patients at high-risk for MDROs to inform Illinois' XDRO registry. Population, hospital and LTACH patients. Domain, regional control including long-term care facilities. Project 2: Regional active MDRO surveillance with genomic analysis. Population, hospitals, LTACHs and nursing homes. Domain, containment of novel resistance. Project 3: Geospatial, ecologic, and clinical risk factors for community-associated ESBL-producers. Population, emergency department and ambulatory patients of two large, urban health systems. Domain, community-associated antimicrobial-resistant infections. Project 4: Genomic epidemiology of MDRO transmission in ICUs. Population, hospital ICU patients. Domain, applying innovative research methodology to evaluate MDRO transmission. Project 5: Adverse health outcomes associated with microbiota disruption. Population, medical ICU patients. Domains, effects of antibiotic use and diagnostics—evaluating measures of the microbiome. Project 6: Generate and export reports on antimicrobial use metrics from a national common data model. Population, hospital patients. Domain, Antimicrobial stewardship