Semi-Volatile PCBs: Sources, Exposures, Toxicities

 描述(由申请人提供)：爱荷华大学超级基金研究计划(ISRP)是一项共同努力，涉及生物医学和环境研究领域的基础、机械和应用研究项目，涉及半挥发性多氯联苯(PCB)。ISRP的总体目标是确定半挥发性多氯联苯的大气来源、暴露和对人类健康的潜在后果。为实现这一目标，ISRP解决了低卤化多氯联苯的挥发、运输和由此暴露的问题，特别是与受污染的水、前工业场所和建筑物(特别是学校建筑)有关的多氯联苯。我们计划确定暴露的途径，着眼于预防或限制暴露并改善影响。ISRP汇集了17名科学家，代表5所学院和2所大学的7个系。我们将共同努力，测量多氯联苯的来源、运输和环境暴露(项目4和6)；它们在动物和人类中的分布、新陈代谢和毒性(项目1、3和7)；以及植物修复的新方法(项目5)。拟议的研究包括一项以社区为基础的参与性研究项目--一项关于在芝加哥大都市区较低氯化多氯联苯来源附近生活或工作的公民的暴露情况。我们喜欢芝加哥、伊利诺伊州和东芝加哥的公民团体的合作，在那里，许多少数民族公民生活在非工业化地点附近的贫困线以下。我们的研究项目和整体效率得到六个核心的支持：管理、综合、分析、培训、研究翻译和社区参与-帮助项目协调、信息传输、实验设计和分析以及研究评估。合成核心合成所有要研究的化合物/混合物，而分析核心提供从新陈代谢到运动的关键成分信息。社区参与和研究翻译核心将研究成果传递给各种利益攸关方，并让这些利益攸关方参与研究活动。培训核心和研究项目每年为16名学生和博士后学者提供培训(在前一个供资期间培训了70名)。评估/评价进程在我们由8名成员组成的外部咨询委员会年度会议上达到高潮。总体而言，这一多学科计划带来了广泛的经验和专业知识以及机构资源，以解决与超级基金化学品相关的问题，这些问题对中西部和国家至关重要。

 DESCRIPTION (provided by applicant): The Superfund Research Program at The University of Iowa (ISRP) is a joint endeavor involving basic, mechanistic, and applied research projects in biomedical and environmental research areas addressing semi- volatile polychlorinated biphenyls (PCBs). The overall goal of the ISRP is to identify atmospheric sources, exposures, and potential consequences to human health of semi-volatile PCBs. To achieve this goal, the ISRP addresses volatilization, transport and resultant exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, former industrial sites, and buildings (especially school buildings). We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The ISRP brings together 17 scientists, representing 7 departments in 5 colleges, and two universities. Working together, we will measure sources, transport and environmental exposure of PCBs (Projects 4 and 6); their distribution, metabolism and toxicity in animals and humans (Projects 1, 3 and 7); and novel methods of phytoremediation (Project 5). Proposed studies include a community-based participatory research project-an of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in the Chicago Metropolitan area. We enjoy the cooperation of citizen groups in Chicago, IL and East Chicago, IN where many ethnic-minority citizens are living below the poverty line near de- industrialized sites. Our research projects and overall efficiency are supported by six cores: Administration, Synthesis, Analytical, Training, Research Translation and Community Engagement - which assist the projects in coordination, information transfer, design and analysis of experiments, and assessment of research. The Synthesis Core synthesizes all compounds/mixtures to be studied, while the Analytical Core provides critical compositional information from metabolism to movement. Community Engagement and Research Translation Cores transmit research findings to a variety of stakeholders and involve those stakeholders in research activities. A Training Core and the research projects provide for the training of 16 students and postdoctoral scholars each year (70 have been trained in the previous funding period). The assessment / evaluation process culminates in an annual meeting of our 8-member External Advisory Committee. Overall this multidisciplinary program brings a broad range of experience and expertise, and institutional resources, to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.