Semi-Volatile PCBs: Sources, Exposures, Toxicities

半挥发性多氯联苯：来源、暴露、毒性

• 批准号: 9481461
• 负责人: LARRY W ROBERTSON
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-12 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9481461
• 关键词: Address; Advisory Committees; Animals; Applied Research; Area; Biochemical; Biological; Body Burden; Boston; Chemicals; Chicago; Collaborations; Communication; Communities; Data; Detection; Development; Educational workshop; Endocrine; Environment; Environmental Exposure; Environmental Health; Environmental Pollutants; Europe; Evaluation; Exposure to; Eye; Faculty; Family; Federal Aid; Feedback; Fostering; Funding; Goals; Hazardous Substances; Health; Health Professional; Human; Industrialization; Inhalation Exposure; International; International Agency for Research on Cancer; Intervention; Iowa; Joints; Knowledge; Laboratories; Malignant Neoplasms; Measures; Metabolism; Methods; Midwestern United States; Molecular; Movement; Mus; Plants; Policies; Polychlorinated Biphenyls; Population; Positioning Attribute; Poverty; Process; Publications; Rattus; Reaction; Recommendation; Regulation; Research; Research Activity; Research Project Grants; Resources; Risk; Risk Assessment; Schools; Scientist; Site; Soil; Source; Students; Superfund; Techniques; Technology; Testing; Toxic effect; Training; Translating; Translational Research; Translations; Universities; Ursidae Family; Volatilization; Water; Wood material; Work; carcinogenicity; cellular targeting; college; community based participatory research; contaminated water; design; ethnic minority population; experience; experimental study; exposure route; falls; improved; meetings; member; metropolitan; multidisciplinary; novel; novel strategies; prevent; programs; public health relevance; remediation; superfund chemical; toxicant; uptake

 DESCRIPTION (provided by applicant): The Superfund Research Program at The University of Iowa (ISRP) is a joint endeavor involving basic, mechanistic, and applied research projects in biomedical and environmental research areas addressing semi- volatile polychlorinated biphenyls (PCBs). The overall goal of the ISRP is to identify atmospheric sources, exposures, and potential consequences to human health of semi-volatile PCBs. To achieve this goal, the ISRP addresses volatilization, transport and resultant exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, former industrial sites, and buildings (especially school buildings). We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The ISRP brings together 17 scientists, representing 7 departments in 5 colleges, and two universities. Working together, we will measure sources, transport and environmental exposure of PCBs (Projects 4 and 6); their distribution, metabolism and toxicity in animals and humans (Projects 1, 3 and 7); and novel methods of phytoremediation (Project 5). Proposed studies include a community-based participatory research project-an of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in the Chicago Metropolitan area. We enjoy the cooperation of citizen groups in Chicago, IL and East Chicago, IN where many ethnic-minority citizens are living below the poverty line near de- industrialized sites. Our research projects and overall efficiency are supported by six cores: Administration, Synthesis, Analytical, Training, Research Translation and Community Engagement - which assist the projects in coordination, information transfer, design and analysis of experiments, and assessment of research. The Synthesis Core synthesizes all compounds/mixtures to be studied, while the Analytical Core provides critical compositional information from metabolism to movement. Community Engagement and Research Translation Cores transmit research findings to a variety of stakeholders and involve those stakeholders in research activities. A Training Core and the research projects provide for the training of 16 students and postdoctoral scholars each year (70 have been trained in the previous funding period). The assessment / evaluation process culminates in an annual meeting of our 8-member External Advisory Committee. Overall this multidisciplinary program brings a broad range of experience and expertise, and institutional resources, to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.

 描述（由申请人提供）：爱荷华州大学的超级基金研究计划（ISRP）是一项共同奋进，涉及生物医学和环境研究领域的基础、机械和应用研究项目，涉及半挥发性多氯联苯（PCB）。ISRP的总体目标是确定半挥发性多氯联苯的大气来源、暴露及其对人类健康的潜在影响。为实现这一目标，国际战略和预防方案处理了低卤化多氯联苯的挥发、迁移和由此产生的接触问题，特别是那些与受污染的沃茨、前工业场地和建筑物（特别是学校建筑物）有关的多氯联苯。我们计划确定接触途径，以防止或限制接触并改善影响。ISRP汇集了17名科学家，代表5所学院和两所大学的7个部门。通过合作，我们将测量多氯联苯的来源，运输和环境暴露（项目4和6）;它们在动物和人类中的分布，代谢和毒性（项目1，3和7）;以及植物修复的新方法（项目5）。拟议的研究包括一个以社区为基础的参与性研究项目--一个关于在芝加哥大都市区低氯化多氯联苯来源附近生活或工作的公民接触情况的研究项目。我们很高兴与伊利诺伊州芝加哥和东芝加哥的公民团体合作，那里的许多少数民族公民生活在贫困线以下，靠近非工业化地区。我们的研究项目和整体效率由六个核心支持：管理，综合，分析，培训，研究翻译和社区参与-这有助于协调，信息传递，实验设计和分析以及研究评估项目。合成核心合成所有待研究的化合物/混合物，而分析核心提供从代谢到运动的关键成分信息。社区参与和研究翻译核心将研究成果传递给各种利益相关者，并让这些利益相关者参与研究活动。培训核心和研究项目每年为16名学生和博士后学者提供培训（在上一个资助期内培训了70名）。评估/评价过程的高潮是我们8名成员组成的外部咨询委员会的年度会议。总的来说，这个多学科计划带来了广泛的经验和专业知识，以及机构资源，承担与超级基金化学品相关的问题，这是至关重要的中西部和国家。