NRG Oncology NCORP Research Base

描述（由申请人提供）：本提案的目的是为NRG肿瘤研究基地建立和维护NCORP（国家癌症研究所社区肿瘤研究计划）。NRG NCORP是将NCI三个癌症合作小组（NSABP、RTOG和GOG）的传统社区临床肿瘤项目（CCOPs）进行整合的结果。这些团体作为CCOP研究基地，总共有超过100年的经验。NRG NCORP由多学科的研究人员和患者倡导者组成，旨在实现以下目标：1)设计和开展癌症预防、控制和筛选临床试验；2)设计和嵌入治疗试验中患者报告的结果3)设计和开展癌症护理提供研究；4)加强在国家临床试验网络（NCTN）下进行的治疗和成像试验的社区可及性；5)将差异研究问题纳入临床试验和癌症护理提供研究。为了使NRG NCORP能够实现这些目标，该小组将：充分参与NRG肿瘤学的领导，并将确定NRG NCORP活动和资源的科学方向和优先级，并监督与NRG NCORP目标相关的转化研究、临床试验活动和相关研究。与NRG统计和数据管理中心一起，该团队将提供有效的、方法学上最新的试验设计、监测、报告和分析；建立基础设施，以支持我们的癌症护理提供研究议程；提供全面的数据管理质量控制和质量保证方案，确保数据的完整性和数据分析的及时性；利用先进的信息技术，强调数据收集和管理的安全性、及时性和效率；提供RT认证和质量保证；并为机构临床研究助理、研究主席、当地首席研究员和其他参与NRG NCORP研究议程的人员提供教育和培训。此外，为了实现这些目标，NRG NCORP将与NCI指定的NCORP社区医生和患者倡导者以及NCI和其他NCI赞助的实体（合作团体，癌症中心，孢子）充分合作，在NCTN内合作，改善癌症治疗和受癌症影响的患者的生活质量。

DESCRIPTION (provided by applicant): The objective of this proposal is to establish and maintain the NCORP (National Cancer Institute Community Oncology Research Program) for the NRG Oncology research base. The NRG NCORP is the result of aligning the legacy CCOPs (Community Clinical Oncology Programs) from three NCI Cancer Cooperative Groups: NSABP, RTOG and GOG. These groups together have over almost 100 years of combined experience serving as CCOP Research Bases. NRG NCORP, comprised of a multi-disciplinary team of investigators and patient advocates, is poised to carry out the objectives of: 1) designing and conducting cancer prevention, control and screening clinical trials; 2) designing and embedding patient reported outcomes in therapeutic trials 3) designing and conducting cancer care delivery research; 4) enhancing community access to treatment and imaging trials conducted under the National Clinical Trials Network (NCTN) and 5) integrating disparity research questions into clinical trials and cancer care delivery research. To allow NRG NCORP to meet these goals, the group will: participate fully in NRG Oncology leadership and will determine the scientific direction and prioritization of the NRG NCORP activities and resources and oversee the translational research, clinical trial activities, and correlative studies related to the aims of NG NCORP. With the NRG Statistical and Data Management Center, this team will provide efficient, methodologically up-to-date trial design, monitoring, reporting, and analysis; build an infrastructure to support our cancer care delivery research agenda; provide comprehensive data management quality control and quality assurance programs to ensure high data integrity and timely data for analysis; leverage cutting edge information technology emphasizing security, timeliness, and efficiency of data collection and management; providing RT credentialing and quality assurance; and provide education and training for institutional Clinical Research Associates, Study Chairs, local Principal Investigators and others involved in the NRG NCORP research agenda. Further, to accomplish these aims NRG NCORP will engage fully with NCI-designated NCORP community physicians and patient advocates as well as the NCI and other NCl-sponsored entities (cooperative groups, cancer centers, SPOREs) to collaborate across the NCTN to improve cancer care and quality of life for patients affected by cancer.