NRG Oncology NCORP Research Base

NRG肿瘤学NCORP研究基地

• 批准号: 10247230
• 负责人: Deborah Watkins Bruner
• 金额: $ 14.96万
• 依托单位: NRG ONCOLOGY FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10247230
• 关键词: Address; Adjuvant; Advocate; Affect; Aftercare; Area; Behavior Therapy; Cancer Center; Cancer Control; Cancer Control Research; Caring; Clinical; Clinical Research Associate; Clinical Trials; Clinical Trials Design; Collaborations; Collection; Communities; Community Clinical Oncology Program; Community Physician; Concept Review; Correlative Study; Credentialing; Data; Data Analyses; Data Collection; Development; Disease; Elderly; Ensure; Evidence based intervention; Exposure to; Family; Funding; Gender; Genetic; Goals; Grant; Gynecologic Oncology Group; Health Services Accessibility; Hospice Care; Image; Immunotherapy; Information Technology; Infrastructure; Intervention; Intervention Trial; Leadership; Localized Malignant Neoplasm; Lymphedema; Malignant Neoplasms; Mentorship; Methodology; Minority; Modality; Modification; Molecular; Monitor; National Cancer Institute; National Clinical Trials Network; National Surgical Adjuvant Breast and Bowel Project; Neurocognitive; Oncology; Outcome; Outcomes Research; Palliative Care; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Phase; Primary Health Care; Principal Investigator; Quality Control; Quality of life; Radiation Oncology; Radiation Therapy Oncology Group; Radiation therapy; Randomized; Reporting; Research; Research Personnel; Resources; Risk Reduction; Rural Population; Security; Series; Sex Functioning; Site; Solid Neoplasm; Southwest Oncology Group; Survivors; Symptoms; Testing; Therapeutic Clinical Trial; Therapeutic Trials; Time; Toxic effect; Training; Training Activity; Training Programs; Training and Education; Translational Research; Treatment-Related Cancer; Woman; Women' s Health; Work; base; biomarker evaluation; cancer care; cancer diagnosis; cancer health disparity; cancer prevention; cancer risk; cancer therapy; care delivery; care outcomes; clinical imaging; clinical practice; community center; cost effectiveness; data integrity; data management; design; disorder risk; effectiveness testing; ethnic minority population; evidence base; experience; health disparity; improved; innovation; member; multidisciplinary; next generation; programs; quality assurance; racial minority; screening; survivorship; symptom management; therapeutic evaluation; therapy design; treatment trial; trial design; underserved minority

The objective of this proposal is to establish and maintain the NCORP (National Community Oncology Research Program) for the NRG Oncology research base. The NRG NCORP is the result of aligning the legacy CCOPs (Community Clinical Oncology Programs) from three NCI Cancer Cooperative Groups: NSABP, RTOG and GOG. These groups together have over almost 100 years of combined experience serving as CCOP Research Bases. NRG NCORP, comprised of a multi-disciplinary team of investigators and patient advocates, is poised to carry out the objectives of: 1) designing and conducting cancer prevention, control and screening clinical trials; 2) designing and embedding patient reported outcomes in both primary NCOPR trials as well as NRG therapeutic trials 3) designing and conducting cancer care delivery research; 4) enhancing community access to treatment and imaging trials conducted under the National Clinical Trials Network (NCTN) and 5) conducting primary intervention trials and integrating health disparity research questions into cancer care delivery research and treatment trials. To allow NRG NCORP to meet these goals, the group will: participate fully in NRG Oncology leadership and will determine the scientific direction and prioritization of the NRG NCORP activities and resources and oversee the translational research, clinical trial activities, and correlative studies related to the aims of NRG NCORP. With the NRG Statistical and Data Management Center (SDMC), this team will provide efficient, methodologically up-to-date trial design with a focus on NCORP specific needs such as patient-reported repeated longitudinal assessments and cluster-randomized designs. NRG NCORP will provide study monitoring, reporting, and analysis; build an infrastructure to support our cancer care delivery research agenda; provide comprehensive data management quality control and quality assurance programs to ensure high data integrity and timely data for analysis; leverage cutting edge information technology emphasizing security, timeliness, and efficiency of data collection and management; providing RT credentialing and quality assurance; and provide education and training for institutional Clinical Research Associates, Study Chairs, local Principal Investigators and others involved in the NRG NCORP research agenda. Further, to accomplish these aims NRG NCORP will engage fully with NCI-designated NCORP community physicians and patient advocates as well as the NCI and other NCI-sponsored entities (cooperative groups, cancer centers, SPOREs) to collaborate across the NCTN to improve cancer prevention and control, cancer care and outcomes, and quality of life for patients affected by cancer.

本提案的目的是建立和维护NCORP（国家社区 肿瘤学研究计划）为NRG肿瘤学研究基地。NRG NCORP是 将三个NCI的传统CCOP（社区临床肿瘤学计划） 癌症合作组织：NSABP、RTOG和GOG。这些团体加起来有超过 近100年的综合经验，作为CCOP研究基地。NRG NCORP， 由多学科的研究人员和患者倡导者组成的团队， 制定了以下目标：1）设计和开展癌症预防、控制和筛查 临床试验; 2）设计并嵌入患者报告的主要NCOPR结局 试验以及NRG治疗试验3）设计和实施癌症护理服务 研究; 4）加强社区获得治疗和成像试验根据 国家临床试验网络（NCTN）和5）进行初级干预试验， 将健康差异研究问题纳入癌症护理提供研究和治疗 审判为了使NRG NCORP能够实现这些目标，该集团将： 肿瘤学领导层，并将确定NRG的科学方向和优先顺序 NCORP的活动和资源，并监督转化研究，临床试验活动， 以及与NRG NCORP目标相关的相关研究。NRG统计和数据 管理中心（SDMC），该团队将提供高效，方法学上最新的试验 设计重点关注NCORP特定需求，例如患者报告的重复纵向 评估和随机分组设计。NRG NCORP将提供研究监查， 报告和分析;建立基础设施，以支持我们的癌症护理提供研究 提供全面的数据管理、质量控制和质量保证 确保高数据完整性和及时分析数据的计划;利用尖端技术 信息技术强调数据收集的安全性、及时性和效率， 管理;提供RT认证和质量保证;并提供教育和 机构临床研究助理、研究主席、当地主要研究者的培训 和其他参与NRG NCORP研究议程的人。此外，为了实现这些目标， NRG NCORP将与NCI指定的NCORP社区医生和患者充分接触 倡导者以及NCI和其他NCI赞助的实体（合作团体，癌症 中心，SPORE）在NCTN合作，以改善癌症预防和控制， 癌症护理和结果，以及癌症患者的生活质量。