Liver Injury and Iron Homeostasis in Health and Disease

铁质失调和肝脏疾病是社会的重大负担，影响到许多正值壮年的人。铁代谢紊乱在许多紊乱和疾病中也起着重要作用，包括癌症、神经退行性疾病和铁超载疾病，以及与慢性疾病相关的贫血。我的目标是了解所涉及的分子和机制，并制定策略和试剂来诊断、预防和治疗肝脏和铁相关疾病。

Iron disorders and liver disease are a significant burden on society, affecting many in the prime of their life. Disordered iron metabolism also plays a significant role in many disorders and diseases including cancers, neurodegenerative and iron overload disorders, and anaemia associated with chronic disease. My objective is to understand the molecules and mechanisms involved, and to develop strategies and reagents to diagnose, prevent and treat liver and iron-related disease.