Development and Translation of High Performance Receive Arrays for Pediatric MRI

用于儿科 MRI 的高性能接收阵列的开发和转化

• 批准号: 9283536
• 负责人: John M. Pauly
• 金额: $ 110.8万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9283536
• 关键词: Abdomen; Acceleration; Age; Anatomy; Anesthesia procedures; Child; Childhood; Clinic; Clinical; Collaborations; Development; Diagnosis; Diagnostic; Electronics; Engineering; Environment; Generations; Goals; Healthcare; Image; Incidence; Industry; Infant; Ink; Institution; Ionizing radiation; Letters; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Manufacturer Name; Medical; Morphologic artifacts; Motion; Motivation; Newborn Infant; Patients; Pediatric Radiology; Pediatrics; Performance; Plasticizers; Population; RF coil; Research; Research Personnel; Risk; Scanning; Silicon; Structure; System; Technology; Testing; Textiles; Toddler; Translations; Universities; Wireless Technology; Work; X-Ray Computed Tomography; commercialization; design; design and construction; flexibility; flexible electronics; imaging capabilities; imaging modality; improved; innovation; light weight; novel strategies; pediatric patients; prototype; public health relevance; success; validation studies

DESCRIPTION (provided by applicant): Motivation: We aim to develop and implement new approaches to the design of high performance receive arrays for pediatric MRI. The ultimate goal is flexible, light, comfortable arrays that enable children to undergo MRI without anesthesia. This project builds on our success in "Rapid, Robust Pediatric MRI" EB R01009690, Vasanawala, PI. In it, the investigators of the current proposal developed and prototyped the first dedicated pediatric abdominal array coil, testing it on hundreds of children. This design is being commercialized by GE Healthcare, and is on the current product roadmap. This is a major advance for pediatric MRI. The enhanced sensitivity and parallel imaging capability of this array has been critical for developing highly accelerated imaging methods based on compressed sensing, parallel imaging, and adaptive motion correction that were the other aims of the previous R01. Over the last four years, these developments resulted in a 250% increase in pediatric body MRI utilization at our institution and a 50% decrease in CT. Approach: This was our first step towards making MRI much more accessible and effective for pediatric patients. We are already well along in the next steps, the subject of this proposal. The project proceeds in a sequence of developments that range from short term goals that will have immediate clinical and commercial impact, to intermediate and long term goals that will fundamentally change the way receive array coils are designed, constructed, and used. The motivation for this project is pediatric MRI, because these patients are the most sensitive to the environment, and would benefit most from less intrusive arrays with higher performance. However, once these technologies are established, we expect translation to all receive arrays. The project will proceed in three development aims followed by a clinical validation study. The first is to develop and fabricate a second generation pediatric array coil that is more flexible, so that it will confom to different size pediatric patients. We will pilot test the coil in the clinic to determine performance and patient acceptance. The second aim is to use printed electronics technology to fabricate array coils that are completely flexible, light and can be incorporated into children's garments or blankets. Various configurations of these flexible coils will be pilot tested in the clinic. The third aim is to develop small, low power, high performance electronics for flexible array coils, with the ultimate goal of completely wireless arrays. The results of this aim will be combined with developments of the second aim to achieve wireless completely flexible printed coils. Finally, the new coils will be tested in the clinic to determine their relative abilities toyield diagnostically successful exams on children of varying ages compared to current coil arrays. Significance: The result will be a revolutionary change in the way that receives arrays are designed, constructed and used. This will increase the capability of pediatric MRI, due to the better fit of the coils to anatomy. Coils will be less formidable and less intrusive, increasing children's' acceptance.

描述（由申请人提供）：动机：我们的目标是开发和实施新的方法来设计高性能的儿童MRI接收阵列。最终目标是灵活、轻便、舒适的阵列，使儿童无需麻醉即可接受核磁共振成像。