Development and Translation of High Performance Receive Arrays for Pediatric MRI

用于儿科 MRI 的高性能接收阵列的开发和转化

• 批准号: 9283536
• 负责人: John M. Pauly
• 金额: $ 110.8万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9283536
• 关键词: Abdomen; Acceleration; Age; Anatomy; Anesthesia procedures; Child; Childhood; Clinic; Clinical; Collaborations; Development; Diagnosis; Diagnostic; Electronics; Engineering; Environment; Generations; Goals; Healthcare; Image; Incidence; Industry; Infant; Ink; Institution; Ionizing radiation; Letters; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Manufacturer Name; Medical; Morphologic artifacts; Motion; Motivation; Newborn Infant; Patients; Pediatric Radiology; Pediatrics; Performance; Plasticizers; Population; RF coil; Research; Research Personnel; Risk; Scanning; Silicon; Structure; System; Technology; Testing; Textiles; Toddler; Translations; Universities; Wireless Technology; Work; X-Ray Computed Tomography; commercialization; design; design and construction; flexibility; flexible electronics; imaging capabilities; imaging modality; improved; innovation; light weight; novel strategies; pediatric patients; prototype; public health relevance; success; validation studies

DESCRIPTION (provided by applicant): Motivation: We aim to develop and implement new approaches to the design of high performance receive arrays for pediatric MRI. The ultimate goal is flexible, light, comfortable arrays that enable children to undergo MRI without anesthesia. This project builds on our success in "Rapid, Robust Pediatric MRI" EB R01009690, Vasanawala, PI. In it, the investigators of the current proposal developed and prototyped the first dedicated pediatric abdominal array coil, testing it on hundreds of children. This design is being commercialized by GE Healthcare, and is on the current product roadmap. This is a major advance for pediatric MRI. The enhanced sensitivity and parallel imaging capability of this array has been critical for developing highly accelerated imaging methods based on compressed sensing, parallel imaging, and adaptive motion correction that were the other aims of the previous R01. Over the last four years, these developments resulted in a 250% increase in pediatric body MRI utilization at our institution and a 50% decrease in CT. Approach: This was our first step towards making MRI much more accessible and effective for pediatric patients. We are already well along in the next steps, the subject of this proposal. The project proceeds in a sequence of developments that range from short term goals that will have immediate clinical and commercial impact, to intermediate and long term goals that will fundamentally change the way receive array coils are designed, constructed, and used. The motivation for this project is pediatric MRI, because these patients are the most sensitive to the environment, and would benefit most from less intrusive arrays with higher performance. However, once these technologies are established, we expect translation to all receive arrays. The project will proceed in three development aims followed by a clinical validation study. The first is to develop and fabricate a second generation pediatric array coil that is more flexible, so that it will confom to different size pediatric patients. We will pilot test the coil in the clinic to determine performance and patient acceptance. The second aim is to use printed electronics technology to fabricate array coils that are completely flexible, light and can be incorporated into children's garments or blankets. Various configurations of these flexible coils will be pilot tested in the clinic. The third aim is to develop small, low power, high performance electronics for flexible array coils, with the ultimate goal of completely wireless arrays. The results of this aim will be combined with developments of the second aim to achieve wireless completely flexible printed coils. Finally, the new coils will be tested in the clinic to determine their relative abilities toyield diagnostically successful exams on children of varying ages compared to current coil arrays. Significance: The result will be a revolutionary change in the way that receives arrays are designed, constructed and used. This will increase the capability of pediatric MRI, due to the better fit of the coils to anatomy. Coils will be less formidable and less intrusive, increasing children's' acceptance.

描述（由申请人提供）： 动机：我们的目标是开发和实施新方法来设计用于儿科 MRI 的高性能接收阵列。最终目标是灵活、轻便、舒适的阵列，使儿童能够在没有麻醉的情况下接受核磁共振成像。 该项目建立在我们“快速、稳健的儿科 MRI”EB R01009690（Vasanawala，PI）的成功之上。其中，当前提案的研究人员开发并制作了第一个专用儿科腹部阵列线圈的原型，并在数百名儿童身上进行了测试。该设计正在由 GE Healthcare 进行商业化，并已列入当前的产品路线图。这是儿科 MRI 的重大进步。该阵列增强的灵敏度和并行成像能力对于开发基于压缩感知、并行成像和自适应运动校正的高度加速成像方法至关重要，而这也是之前 R01 的其他目标。在过去四年中，这些发展导致我们机构的儿科身体 MRI 利用率增加了 250%，而 CT 利用率下降了 50%。方法：这是我们为让儿科患者更容易获得和更有效地使用 MRI 迈出的第一步。我们已经在接下来的步骤中取得了进展，即本提案的主题。该项目将进行一系列开发，从具有直接临床和商业影响的短期目标，到将从根本上改变接收阵列线圈的设计、构建和使用方式的中长期目标。该项目的动机是儿科 MRI，因为这些患者对环境最敏感，并且会从侵入性较小、性能较高的阵列中获益最多。然而，一旦这些技术建立起来，我们期望能够应用于所有接收阵列。该项目将按照三个开发目标进行，随后进行临床验证研究。首先是开发和制造更加灵活的第二代儿科阵列线圈，以适应不同体型的儿科患者。我们将在诊所对线圈进行试点测试，以确定性能和患者接受度。第二个目标是利用印刷电子技术来制造完全柔性、轻便且可以融入儿童服装或毛毯中的阵列线圈。这些柔性线圈的各种配置将在诊所进行试点测试。第三个目标是开发用于柔性阵列线圈的小型、低功耗、高性能电子器件，最终目标是完全无线阵列。该目标的结果将与第二个目标的发展相结合，以实现无线完全柔性印刷线圈。最后，新线圈将在诊所进行测试，以确定与当前线圈阵列相比，它们对不同年龄的儿童进行成功诊断检查的相对能力。意义：其结果将是接收阵列的设计、构建和使用方式发生革命性的变化。由于线圈更适合解剖结构，这将提高儿科 MRI 的能力。线圈将不再那么令人生畏、更少侵入性，从而提高孩子们的接受度。