Development and Translation of High Performance Receive Arrays for Pediatric MRI

用于儿科 MRI 的高性能接收阵列的开发和转化

• 批准号: 9283536
• 负责人: John M. Pauly
• 金额: $ 110.8万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9283536
• 关键词: Abdomen; Acceleration; Age; Anatomy; Anesthesia procedures; Child; Childhood; Clinic; Clinical; Collaborations; Development; Diagnosis; Diagnostic; Electronics; Engineering; Environment; Generations; Goals; Healthcare; Image; Incidence; Industry; Infant; Ink; Institution; Ionizing radiation; Letters; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Manufacturer Name; Medical; Morphologic artifacts; Motion; Motivation; Newborn Infant; Patients; Pediatric Radiology; Pediatrics; Performance; Plasticizers; Population; RF coil; Research; Research Personnel; Risk; Scanning; Silicon; Structure; System; Technology; Testing; Textiles; Toddler; Translations; Universities; Wireless Technology; Work; X-Ray Computed Tomography; commercialization; design; design and construction; flexibility; flexible electronics; imaging capabilities; imaging modality; improved; innovation; light weight; novel strategies; pediatric patients; prototype; public health relevance; success; validation studies

DESCRIPTION (provided by applicant): Motivation: We aim to develop and implement new approaches to the design of high performance receive arrays for pediatric MRI. The ultimate goal is flexible, light, comfortable arrays that enable children to undergo MRI without anesthesia. This project builds on our success in "Rapid, Robust Pediatric MRI" EB R01009690, Vasanawala, PI. In it, the investigators of the current proposal developed and prototyped the first dedicated pediatric abdominal array coil, testing it on hundreds of children. This design is being commercialized by GE Healthcare, and is on the current product roadmap. This is a major advance for pediatric MRI. The enhanced sensitivity and parallel imaging capability of this array has been critical for developing highly accelerated imaging methods based on compressed sensing, parallel imaging, and adaptive motion correction that were the other aims of the previous R01. Over the last four years, these developments resulted in a 250% increase in pediatric body MRI utilization at our institution and a 50% decrease in CT. Approach: This was our first step towards making MRI much more accessible and effective for pediatric patients. We are already well along in the next steps, the subject of this proposal. The project proceeds in a sequence of developments that range from short term goals that will have immediate clinical and commercial impact, to intermediate and long term goals that will fundamentally change the way receive array coils are designed, constructed, and used. The motivation for this project is pediatric MRI, because these patients are the most sensitive to the environment, and would benefit most from less intrusive arrays with higher performance. However, once these technologies are established, we expect translation to all receive arrays. The project will proceed in three development aims followed by a clinical validation study. The first is to develop and fabricate a second generation pediatric array coil that is more flexible, so that it will confom to different size pediatric patients. We will pilot test the coil in the clinic to determine performance and patient acceptance. The second aim is to use printed electronics technology to fabricate array coils that are completely flexible, light and can be incorporated into children's garments or blankets. Various configurations of these flexible coils will be pilot tested in the clinic. The third aim is to develop small, low power, high performance electronics for flexible array coils, with the ultimate goal of completely wireless arrays. The results of this aim will be combined with developments of the second aim to achieve wireless completely flexible printed coils. Finally, the new coils will be tested in the clinic to determine their relative abilities toyield diagnostically successful exams on children of varying ages compared to current coil arrays. Significance: The result will be a revolutionary change in the way that receives arrays are designed, constructed and used. This will increase the capability of pediatric MRI, due to the better fit of the coils to anatomy. Coils will be less formidable and less intrusive, increasing children's' acceptance.

描述（由申请人提供）：动机：我们旨在开发和实施新的方法来设计高性能的小儿MRI阵列。最终目标是灵活，轻巧，舒适的阵列，使孩子们可以在不麻醉的情况下进行MRI。 该项目以我们在PI的Vasanawala的“快速，健壮的小儿MRI”中的成功为基础。在其中，当前提案的研究人员制定并原型制造了第一个专用的小儿腹部阵列线圈，对数百名儿童进行了测试。 GE Healthcare正在商业化此设计，并且正在当前的产品路线图上。这是小儿MRI的重大进步。该阵列的增强灵敏度和并行成像能力对于基于压缩感应，并行成像和适应性运动校正的高度加速成像方法至关重要，这是先前R01的另一个目标。在过去的四年中，这些发展导致我们机构的小儿MRI利用率增加了250％，CT下降了50％。方法：这是我们使MRI对小儿患者更容易获得和有效的第一步。我们已经在下一步（该提案的主题）中走得很好。该项目以一系列发展的序列进行，范围从短期目标的临床和商业影响到中级和长期目标，这些目标从根本上改变了接收阵列线圈的设计，构造和使用。该项目的动机是小儿MRI，因为这些患者对环境最敏感，并且将从较高的侵入性阵列中受益最多。但是，一旦建立了这些技术，我们希望翻译成所有阵列。该项目将在三个开发目标中进行，然后进行临床验证研究。首先是开发和制造一个更灵活的小儿阵列线圈，以便与不同大小的儿科患者相处。我们将试用诊所中的线圈，以确定表现和患者接受。第二个目的是使用印刷的电子技术来制造完全柔性，轻巧的阵列线圈，可以纳入儿童服装或毯子中。这些柔性线圈的各种配置将在诊所进行试点测试。第三个目的是为柔性阵列线圈开发小型，低功率，高性能电子设备，以实现完全无线阵列的最终目标。该目标的结果将与第二个目标的发展相结合，以实现无线的完全柔性印刷线圈。最后，与当前的线圈阵列相比，新的线圈将在诊所进行测试，以确定对不同年龄段儿童的诊断性检查的相对能力。意义：结果将是对接收阵列的设计，构造和使用的革命性变化。由于线圈适合解剖结构，这将增加小儿MRI的能力。线圈将不那么强大，侵入性较低，从而增加了儿童的接受。