自闭症的新遗传模型-猫眼课题宝

自闭症的新遗传模型

批准号：

9251872

负责人：

Craig M Powell

金额：

$62.73万

依托单位：

UT SOUTHWESTERN MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-09-01 至 2021-05-31

来源：

https://reporter.nih.gov/project-details/9251872

关键词：

22q13 Adult Affect Alleles Animal Genetics Animal Model Autistic Disorder Behavior Behavioral Biochemical Birds Brain Brain region Cell Adhesion Clinical Trials Collaborations DNA Sequence Alteration Data Development Disease Early Intervention Electrophysiology (science)Ensure Exons FRAP1 gene Family Fragile X Syndrome Functional disorder Funding Generations Genes Genetic Genetic Models Goals Grooming Guanine Nucleotides Human Human Genetics Intellectual functioning disability Intervention Knock-in Mouse Knock-out Knockout Mice Laboratories Lead Link Methyl-CpG-Binding Protein 2 Modeling Molecular Mutant Strains Mice Mutation Neurodevelopmental Disorder PTEN gene Patients Pharmaceutical Preparations Pharmacology Pharmacotherapy Phenotype Proteins Publications Publishing Rett Syndrome Science Scientist Sirolimus Social Interaction Synapses Syndrome Techniques Time Unbalanced Translocation United States National Institutes of Health Work anxiety-like behavior autism spectrum disorder communication behavior critical developmental period critical period experimental study gene therapy innovation kinase inhibitor loss of function mutation mouse model mutant mutant mouse model neurodevelopment neuroligin 1 neuroligin 3 neuropsychiatry non-genetic novel postsynaptic pre-clinical public health relevance repetitive behavior reverse genetics scaffold social anxiety therapeutic target virtual

项目摘要

项目成果

Craig M Powell的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

DESCRIPTION (provided by applicant): Autism spectrum disorders (ASDs) are common, debilitating disorders affecting social interaction, communication, and repetitive behaviors. Recent genetic findings have identified mutations in synaptic cell adhesion genes and genes encoding their interacting protein partners at central synapses as genetic causes of autism spectrum disorders. This proposal will characterize novel and innovative autism mouse models that allow for brain development to take place with a genetic mutation. These particular models allow for reversal of the mutation at various times during brain development and ultimately in specific brain regions. The goal is to narrow the developmental critical period during which such mutations lead to altered brain function and atypical behavior. This information will allow scientists to focus specifically on the time periods and brain regions critical for generation of atypical behavior. In addition, these studies will substantiate feasibility of genetic and certain pharmacological approaches to treatment of a genetic form of autism. Progress to date is substantial in that the genetically reversible mutant mouse models related to autism have been established and characterization has begun.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文