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Regulation of excitability in a sensory system by cellular and network components

Regulation of excitability in a sensory system by cellular and network components
通过细胞和网络组件调节感觉系统的兴奋性
批准号:
9527902
负责人:
SHOBHANA SIVARAMAKRISHNAN
金额:
$33.14万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-04-01 至 2020-08-31

项目摘要

项目成果

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中文摘要
翻译
项目主管/首席研究员(最后、第一、中):Sivaramakrishnan, Shobhana
英文摘要
Program Director/Principal Investigator (Last, First, Middle): Sivaramakrishnan, Shobhana ABSTRACT The long-term goal of this work is to improve understanding of the neural mechanisms that underlie hearing. To determine how acoustic information is processed by the brain, it is critical to elucidate how sound frequency is represented at different sound levels. This project focusses on the central nucleus of the inferior colliculus (ICC), the auditory nucleus in the midbrain that is critically important in regulating hierarchical processing of acoustic information between the ear and the auditory cortex. For its role in hearing, the ICC receives ascending inputs from most parts of the brainstem and is influenced by descending projections from the auditory cortex. In addition, it contains complex local circuits and unique cell types. Recent work demonstrates that local feedback circuitry in the ICC creates acoustically relevant codes despite inadequate brainstem input. This project aims to understand the mechanisms by which the ICC codes the frequency content of simple and complex sounds. Experiments are based on the broad hypothesis that the representation of frequency by the ICC depends on the spatio-temporal characteristics of its local circuits. Aim 1 will identify structure-function correlates of local circuitry and examine connectivity within and across frequency laminae. We will use electrophysiological recordings and optical imaging in brain slices to identify the mechanisms by which the two principal cell types in the ICC, disc-shaped and stellate cells, interact to generate a map of frequencies. Aim 2 will identify how local circuits contribute to frequency representation of simple sounds. In vivo electrophysiological recordings from the ICC of awake mice will be used to examine the contribution of local circuitry and voltage-gated ion channels to the receptive fields of ICC neurons. Aim 3 will identify how local circuits contribute to frequency representation of vocalizations, which are complex natural sounds. In vivo electrophysiological recordings from awake mice will be used to examine the cellular basis for an overrepresentation of high frequencies in the ICC, and the selectivity of neurons to vocalizations with different frequency content. Dysfunction of the ICC plays a critical role in hearing abnormalities. By examining how the arrangement of local circuitry in the ICC contributes to its importance in transforming frequency information from lower auditory nuclei, our work will lay the groundwork for the mechanisms that underlie the frequency re-organization in the ICC that accompanies auditory pathology and will identify the components of hearing disorders that originate in the lower brainstem, midbrain, or higher regions of the auditory hierarchy. 1
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Regulation of excitability in a sensory system by cellular and network components
  • 批准号:
    7846450
  • 项目类别:
  • 资助金额:
    $33.46万
  • 财政年份:
    2009
  • 负责人:
    SHOBHANA SIVARAMAKRISHNAN
  • 依托单位:
Regulation of excitability in a sensory system by cellular and network components
  • 批准号:
    7204175
  • 项目类别:
  • 资助金额:
    $23.75万
  • 财政年份:
    2006
  • 负责人:
    SHOBHANA SIVARAMAKRISHNAN
  • 依托单位:
Regulation of excitability in a sensory system by cellular and network components
  • 批准号:
    7281407
  • 项目类别:
  • 资助金额:
    $12.77万
  • 财政年份:
    2006
  • 负责人:
    SHOBHANA SIVARAMAKRISHNAN
  • 依托单位:
Regulation of excitability in a sensory system by cellular and network components
  • 批准号:
    7586699
  • 项目类别:
  • 资助金额:
    $24.17万
  • 财政年份:
    2006
  • 负责人:
    SHOBHANA SIVARAMAKRISHNAN
  • 依托单位:
海外基金