Improved imaging of carotid plaque using high-resolution, motion-corrected 3D MRI

使用高分辨率运动校正 3D MRI 改进颈动脉斑块成像

• 批准号: 9334297
• 负责人: DENNIS L PARKER
• 金额: $ 59万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-17 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9334297
• 关键词: Algorithms; Anatomy; Angiography; Arterial Fatty Streak; Caliber; Cardiac; Carotid Artery Plaques; Carotid Endarterectomy; Carotid Stenosis; Clinic; Clinical; Clinical Management; Coupled; Data; Deglutition; Detection; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Disease; Evaluation; Foundations; Future; Goals; Head; Head and neck structure; Hemorrhage; Histology; Image; Inflammation; Location; Magnetic Resonance Imaging; Measurement; Measures; Methods; Monitor; Motion; Neck; Necrosis; Patients; Performance; Physiologic pulse; Positioning Attribute; Protocols documentation; RF coil; Radial; Research; Resolution; Risk; Risk Factors; Schedule; Slide; Societies; Stenosis; Stroke; Thick; Ultrasonography; Work; X-Ray Computed Tomography; clinically relevant; cohort; contrast enhanced; cost; density; design; high resolution imaging; imaging modality; improved; in vivo; individual patient; innovation; novel; performance tests; prevent; prisma; public health relevance; reconstruction; respiratory; temporal measurement; treatment effect

 DESCRIPTION (provided by applicant): Our goal in this project is to overcome major barriers preventing MRI from being the clinical standard for carotid disease evaluation. Carotid MRI is unique in that it has the potential to accurately measure vulnerable plaque markers in addition to the clinically relevant measurement of percent diameter stenosis. In addition to carotid stenosis, studies using MRI in the research setting have found that carotid intraplaque inflammation (IPI), intraplaque hemorrhage (IPH), necrotic core (NC), and fibrous cap (FC) thickness and disruption are important stroke risk factors. Although MRI has the potential to measure these factors, major barriers still exist to using carotid MRI in the clinical setting. These include 1) he lack of a coil specific to the anatomic location of the carotid bifurcation in all patients and 2) he lack of high-resolution MRI sequences to accurately measure lumen, stenosis, and plaque components in the presence of respiratory, cardiac, and swallowing motion. In this project we will: 1) develop a novel carotid imaging coil with modular interchangeable arrays on formers that match the range of patient neck anatomy encountered; 2) develop innovative pulse sequences to accurately measure carotid lumen, stenosis and plaque components; 3) develop pulse sequence methods and reconstruction algorithms to detect and correct motion-corrupted measurements; and 4) validate these results by comparison with histology. The development of tailor-made subject fitting RF coils will increase SNR and allow higher spatial and temporal resolution. This increased SNR from the modular coils coupled with motion- robust sequences will increase accuracy of identifying in-vivo plaque components. This will lay the foundation for future studies using carotid MRI to optimally characterize stroke risk and monitor treatment effects geared toward decreasing IPI, IPH, NC, and stabilizing the FC. These methods that conveniently, consistently, and accurately depict carotid lumen and plaque components will overcome the major barriers to the use of MRI as the clinical standard in characterizing carotid disease. This will facilitate the transition of carotid MRI from the research setting where MRI methods have been developed to the general clinic where benefit to the individual patient will be obtained and costs to society will ultimately be reduced.