Location, location, location: Sub-cellular specific targeting of JNK as a novel therapy in breast cancer.

位置，位置，位置：JNK 的亚细胞特异性靶向作为乳腺癌的新型疗法。

• 批准号: nhmrc : 1148099
• 负责人: Dr David Croucher
• 金额: $ 42.26万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/location-location-location-breast-cancer/1320979
• 关键词: Location; location; Sub; cellular; specific

The ‘triple negative’ breast cancer subtype is the most aggressive form of breast cancer, and unlike other subtypes, there are no drugs to specifically this subtype. While many potential drug targets have been identified, they cannot be utilised clinically because of other beneficial roles within the body. We are now deploying our innovative experimental platforms to specifically target the tumour promoting functions of a protein known as ‘JNK’, whilst retaining its beneficial functions.

“三阴性”乳腺癌亚型是最具侵袭性的乳腺癌形式，与其他亚型不同，没有专门针对这种亚型的药物。尽管已经确定了许多潜在的药物靶点，但由于它们在体内具有其他有益作用，因此无法在临床上使用。我们现在正在部署我们的创新实验平台，专门针对一种名为“JNK”的蛋白质的肿瘤促进功能，同时保留其有益功能。