Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease
自身免疫性脱髓鞘疾病中的免疫治疗调节性 CD8 T 细胞
基本信息
- 批准号:9338988
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-07-01 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptive ImmunotherapyAdoptive TransferAffectAnimal ModelAnti-Inflammatory AgentsAnti-inflammatoryAntigenic SpecificityAntigensAreaAutoantigensAutoimmune DiseasesAutoimmune ProcessCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCD8B1 geneCellsCharacteristicsChronicCountryDataDemyelinating DiseasesDemyelinationsDendritic CellsDevelopmentDiseaseExhibitsExperimental Autoimmune EncephalomyelitisExperimental ModelsGoalsHistologyHumanITGAX geneImmuneImmunizationImmunologicsImmunologyImmunotherapeutic agentImmunotherapyIn VitroInbred C3H MiceInflammatoryInterferon Type IIInterventionIntuitionMHC Class I GenesMediatingModelingMolecularMorbidity - disease rateMultiple SclerosisMultiple Sclerosis LesionsMusMyelinNeuraxisOrganPathogenesisPathogenicityPathologyPathology processesPeripheralPharmaceutical PreparationsPhenotypePlayPopulationProcessRegulationRegulatory T-LymphocyteRelapseReportingRoleSJL MouseSiteT-LymphocyteTherapeuticTherapeutic EffectTransgenic OrganismsVeteransWorkarmautoreactive T cellautoreactivitybasecentral nervous system demyelinating disordercopolymer 1cytotoxicexperimental studyimmunopathologyimmunoregulationin vivoinnovationinsightmouse modelneuroinflammationnovelperforinresponsetraffickingtreatment strategy
项目摘要
Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system (CNS). A
great deal of our understanding about the immunologic processes that underlie MS derives from studies in its
autoimmune animal model, experimental autoimmune encephalomyelitis (EAE). However, the vast majority of
studies in EAE and MS have focused on evaluating and targeting CD4+ T cell responses, with the general
assumption that these diseases are predominantly Th1/Th17-mediated and Th2/Treg-modulated. Recent
reports from others and us indicate that CD8+ T cells play a role in the pathogenesis as well as regulation of
autoimmune demyelination. Our recent studies in MS and EAE have provided evidence for a novel and
unexpected disease suppressive role for CNS-specific CD8+ T cells and also demonstrated the
requirement of CD8+ T cells in mediating effects of glatiramer acetate (GA) immunotherapy. Based on
our data, we hypothesize that a subset of autoantigen-specific or GA-induced CD8 T cells form an
important arm of immune regulation during autoimmune demyelinating disease. We propose that this
process can be harnessed for the development of an effective immunotherapeutic strategy. The
experiments proposed in this application will utilize EAE models to address the fundamental cellular and
molecular mechanisms of immune modulation by intrinsic and therapeutic CD8 T cells. In addition, the most
potent immune suppressive subset of these populations will be defined with the goal of developing a novel
adoptive immunotherapeutic approach. We believe that the proposed experiments will provide greater
fundamental insights into CD8 T cell-mediated immune regulation and pave the way for newer intervention
strategies for this and other immune-mediated diseases.
多发性硬化症(MS)是一种中枢神经系统(CNS)的炎症性脱髓鞘疾病。一个
项目成果
期刊论文数量(0)
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NITIN J KARANDIKAR其他文献
NITIN J KARANDIKAR的其他文献
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{{ truncateString('NITIN J KARANDIKAR', 18)}}的其他基金
Effector-Regulator Immune Interactions During Autoimmune Demyelinating Disease
自身免疫性脱髓鞘疾病期间效应器-调节器免疫相互作用
- 批准号:
10595509 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Effector-Regulator Immune Interactions During Autoimmune Demyelinating Disease
自身免疫性脱髓鞘疾病期间效应器-调节器免疫相互作用
- 批准号:
10359998 - 财政年份:2022
- 资助金额:
-- - 项目类别:
ShEEP Request for Cytek Aurora Spectral Flow Cytometer
ShEEP 请求 Cytek Aurora 光谱流式细胞仪
- 批准号:
9905780 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease
自身免疫性脱髓鞘疾病中的免疫治疗调节性 CD8 T 细胞
- 批准号:
9483533 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease
自身免疫性脱髓鞘疾病中的免疫治疗调节性 CD8 T 细胞
- 批准号:
10248844 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating Disease
自身免疫性脱髓鞘疾病中的免疫治疗调节性 CD8 T 细胞
- 批准号:
10447061 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Immune Dysregulation During Multiple Sclerosis Relapse
多发性硬化症复发期间的免疫失调
- 批准号:
9929670 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Immune Dysregulation During Multiple Sclerosis Relapse
多发性硬化症复发期间的免疫失调
- 批准号:
9915848 - 财政年份:2016
- 资助金额:
-- - 项目类别:
CNS-Specific Regulatory CD8+ T Cells in Autoimmune Demyelination
CNS 特异性调节 CD8 T 细胞在自身免疫性脱髓鞘中的作用
- 批准号:
8627103 - 财政年份:2011
- 资助金额:
-- - 项目类别:
CNS-Specific Regulatory CD8+ T Cells in Autoimmune Demyelination
CNS 特异性调节 CD8 T 细胞在自身免疫性脱髓鞘中的作用
- 批准号:
8648996 - 财政年份:2011
- 资助金额:
-- - 项目类别:
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