RESOURCE/SERVICE CORE A - OCULAR IMAGING MODULE

资源/服务核心 A - 眼部成像模块

• 批准号: 9336309
• 负责人: William Joseph Dupps
• 金额: $ 33.85万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9336309
• 关键词: Angiography; Animal Model; Animals; Anterior; Center Core Grants; Clinic; Collaborations; Core Grant; Cornea; Cryoultramicrotomy; Darkness; Data; Diagnostic; Disease Progression; Eye; Faculty; Fluorescence; Fostering; Foundations; Frozen Sections; Funding; Fundus; Fundus photography; Generations; Glaucoma; Goals; Grant; Image; Imaging Techniques; Imaging technology; Immunohistochemistry; Lasers; Mind; Modeling; Mus; Operative Surgical Procedures; Ophthalmology; Ophthalmoscopy; Optical Coherence Tomography; Oryctolagus cuniculus; Paraffin; Paraffin Embedding; Plastic Embedding; Plasticizers; Process; Productivity; Protocols documentation; Rattus; Recruitment Activity; Research; Research Personnel; Research Support; Resources; Retinal Diseases; Risk; Scanning; Scientist; Services; Staining method; Stains; Standardization; Supervision; Talents; Techniques; Tissue Embedding; Tissue Fixation; Tissue imaging; Transmission Electron Microscopy; Vision; Vision research; Visual system structure; Zebrafish; animal imaging; cellular imaging; ex vivo imaging; experience; faculty research; imaging modality; innovation; microscopic imaging; programs; ranpirnase; sample fixation; tissue processing; treatment planning

Abstract Ocular Imaging Module The Ocular Imaging Module will provide a variety of imaging modalities to the investigators involved in this P30 Core Grant for Vision Research. The module includes live animal (in vivo) imaging with slit lamp and fundus photography, scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT). It also supports tissue and cellular imaging (ex vivo) support, providing routine and specialized tissue fixation techniques, paraffin and plastic tissue embedding, sectioning (paraffin and Cryo) and staining for immunohistochemistry. Microscope imaging techniques include bright field, dark field, differential interference contrast (DIC), fluorescence, and transmission electron microscopy (TEM). It also provides help and advice with the morphometric analysis of generated images. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

摘要