Polycyclic Aromatic Compound Mixture Assessment Program (PAC-MAP)

多环芳香族化合物混合物评估计划（PAC-MAP）

• 批准号: 9575441
• 负责人: BRIAN BURBACK
• 金额: $ 42.99万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-25 至 2018-05-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9575441
• 关键词: Adverse effects; Animals; Anthracenes; Aromatic Compounds; Benzo(a)pyrene; Chemicals; Chemistry; Chrysenes; Complex Mixtures; Contracts; Development; Dose; Ensure; Environmental Exposure; Evaluation; Exposure to; Formulation; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Human; Human Cell Line; Immunotoxicology; Methods; National Toxicology Program; Outcome; Public Health; Pyrenes; Risk Assessment; Risk Factors; Solubility; Specific qualifier value; Testing; Toxic effect; Toxicity Tests; Toxicology; Validation; disorder prevention; in vitro testing; phenanthrene; programs; public health research; screening; sound

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted towards the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. In addition, this contract also provides chemistry support for in vitro testing in multiple animal and human cell lines of a wide variety of chemicals of public health concern.

该项目的目标是为国家毒理学规划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，试验物种以规定的剂量浓度暴露于规定的化学品。该合同通过提供所研究化学物质的特征、所给剂量水平的确认和内部剂量确定，有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果。这些信息对于评估毒性试验和就研究化学品在试验物种中的潜在毒性得出合理、科学的结论至关重要，并最终支持国家毒理学方案和其他联邦机构的风险评估工作。根据本合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解暴露于所研究化学品所产生的风险因素。此外，该合同还为在多种动物和人类细胞系中对引起公共卫生关注的各种化学品进行体外测试提供化学支持。