Botanical Dietary Supplements

该项目的目的是为国家毒理学计划（NTP）研究植物性膳食补充剂的潜在不良影响提供支持。植物膳食补充剂的研究有几个挑战，包括确定有效成分，将它们与观察到的结果联系起来，由于混合物的复杂组成。在毒性研究中，需要进行适当的化学分析，以确保试验物种以规定的剂量浓度暴露于试验物品。本合同描述了在测试程序中研究的植物性膳食补充剂的化学和物理组成。这些信息对于评估毒性试验和就研究化学品在试验物种中的潜在毒性得出合理、科学的结论至关重要，并最终支持国家毒理学方案和其他联邦机构的风险评估工作。此外，该合同还为在多种动物和人类细胞系中对引起公共卫生关注的各种化学品进行体外测试提供化学支持。

The goal of this project is to provide support of National Toxicology Program (NTP) researching the potential adverse effect of botanical dietary supplements. Botanical dietary supplement research has several challenges including identifying the active ingredients to link them to observed outcomes due to complex makeup of the mixtures. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the test articles at the specified dose concentrations. This contract characterizes the chemical and physical composition of the botanical dietary supplements studied in the testing program. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of the National Toxicology Program and other federal agencies. In addition, this contract also provides chemistry support for in vitro testing in multiple animal and human cell lines of a wide variety of chemicals of public health concern.