Botanical Dietary Supplements

该项目的目标是为国家毒理学计划 (NTP) 研究植物膳食补充剂的潜在不利影响提供支持。植物膳食补充剂研究面临一些挑战，包括确定活性成分，将其与由于混合物组成复杂而观察到的结果联系起来。 需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于测试物品。该合同描述了测试计划中研究的植物膳食补充剂的化学和物理成分。这些信息对于评估毒性测试以及得出有关研究化学品在测试物种中的潜在毒性的合理、科学结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，该合同还为多种动物和人类细胞系中涉及公共卫生问题的多种化学品的体外测试提供化学支持。

The goal of this project is to provide support of National Toxicology Program (NTP) researching the potential adverse effect of botanical dietary supplements. Botanical dietary supplement research has several challenges including identifying the active ingredients to link them to observed outcomes due to complex makeup of the mixtures. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the test articles at the specified dose concentrations. This contract characterizes the chemical and physical composition of the botanical dietary supplements studied in the testing program. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of the National Toxicology Program and other federal agencies. In addition, this contract also provides chemistry support for in vitro testing in multiple animal and human cell lines of a wide variety of chemicals of public health concern.