Neural markers of speech error detection and correction abilities in aphasia

失语症言语错误检测和纠正能力的神经标志物

• 批准号: 9561389
• 负责人: Caroline Niziolek
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9561389
• 关键词: Acoustics; Agreement; Anatomy; Aphasia; Area; Auditory; Auditory system; Award; Beds; Behavioral; Biological Assay; Biological Markers; Boston; Brain region; Classification; Clinical; Cognitive deficits; Communication; Communication impairment; Data; Detection; Development Plans; Diagnosis; Diagnostic tests; Disease; Etiology; Failure; Feedback; Goals; Impairment; Individual; Language; Learning; Lesion; Location; Magnetic Resonance Imaging; Magnetoencephalography; Maps; Measures; Mentors; Monitor; Motor; Motor output; Participant; Pathologic; Pathway interactions; Patients; Pattern; Perception; Phase; Plant Roots; Population; Production; Research; Resolution; Series; Signal Transduction; Source; Speech; Speech Disorders; Speech Perception; Speech Sound; Speech Therapy; Stroke; Symptoms; System; Techniques; Testing; Time; Training; Unconscious State; Universities; Variant; Vision; Visual; Voice; Work; aphasic; base; career development; deviant; improved; individual patient; individualized medicine; learning ability; motor control; motor learning; neuroimaging; neurophysiology; novel; personalized medicine; public health relevance; relating to nervous system; research clinical testing; response; sensory feedback; sensory input; stem; temporal measurement; theories; translational research program; visual feedback; visual processing

 DESCRIPTION (provided by applicant): Individuals with aphasia, a disorder caused by damage to language-related brain regions, are often afflicted with speech production difficulties that greatly impair communication. The goal of this K99/R00 Pathway to Independence Award is to provide the candidate, Dr. Caroline Niziolek, with a strong grounding in patient- based research and cutting-edge neural connectivity analysis, enabling her to apply her expertise in speech motor control to investigate the functional abnormalities at the root of this communication disorder. In this proposal, Dr. Niziolek aims to identify the neurophysiological causes of speech production deficits in aphasia and to assess whether feedback-based speech training can ameliorate them. Her recent neuroimaging research in healthy speakers suggests that the auditory system constantly monitors its own speech for small deviations from intended speech sounds, and that successful monitoring may drive an unconscious motor correction of these deviations before they are realized as errors. The central hypothesis of this project is that in speakers with aphasia, production deficits may be due to a failure of detection: that is, the auditory system is not sensitive to an aphasic speaker's own deviations until after they become full-blown speech errors. Importantly, in testing this hypothesis, Dr. Niziolek will look across aphasic patients, regardless of their lesion location or clinically-defined subtype, using an objective neural marker she developed to assess detection ability. Her immediate goal for the K99 phase is to use this neural marker, along with behavioral metrics, to characterize each individual's deficit as either perceptual (difficulty detecting one's own errors) or motor (preservd ability to detect errors but difficulty in carrying out corrective commands). She will then relate these objectively-measured deficits to patterns of lesions and magnetoencephalographic (MEG) connectivity to determine the structural and functional network abnormalities that cause each type of deficit. With this understanding, she plans to carry out a novel speech production training study in the R00 phase of the award. The proposed speech training game uses a visual cursor that is mapped to acoustic input so that participants can use their voice to move the cursor to a visual target. The target will correspond to the production of a given speech sound, such as the "e" in "bed." This training provides a secondary source of sensory feedback for the detection of deviations from a target. By training aphasic patients to learn to hit vocal targets using visual feedback, Dr. Niziolek aims to use an intact system (vision) to retrain the damaged one (auditory detection). Her long-term goal is to use this paradigm in conjunction with the neural marker assessment to develop personalized treatments that are tailored to each patient's specific functional deficit (auditory detection or motor correction). This research career development plan will be carried out at Boston University with an impressive co-mentor team from whom she will gain invaluable clinical and technical training, with the ultimate aim of developing a translational research program that can be extended to other speech disorders.

 描述（由申请人提供）：失语症患者是一种因与语言相关的大脑区域受损而引起的疾病，经常患有言语表达困难，严重损害沟通。 K99/R00 独立之路奖的目标是为候选人 Caroline Niziolek 博士提供基于患者的研究和尖端神经连接分析的坚实基础，使她能够运用她在言语运动控制方面的专业知识来调查这种沟通障碍根源的功能异常。在这项提案中，尼齐奥莱克博士旨在确定失语症患者言语产生缺陷的神经生理学原因，并评估基于反馈的言语训练是否可以改善这些缺陷。她最近对健康说话者进行的神经影像学研究表明，听觉系统会不断监测自己的语音是否与预期语音存在微小偏差，并且成功的监测可能会在这些偏差被意识到为错误之前驱动无意识的运动纠正。该项目的中心假设是 对于患有失语症的说话者，产生缺陷可能是由于未能检测到：也就是说，听觉系统对失语症说话者自己的偏差不敏感，直到它们成为全面的言语错误之后。重要的是，在检验这一假设时，Niziolek 博士将使用她开发的客观神经标记物来评估失语症患者的检测能力，无论他们的病变位置或临床定义的亚型如何。她 K99 阶段的直接目标是使用这种神经标记以及行为指标，将每个人的缺陷描述为感知（难以检测自己的错误）或运动（保留检测错误的能力，但难以执行纠正命令）。然后，她会将这些客观测量的缺陷与病变模式和脑磁图 (MEG) 连接联系起来，以确定导致每种类型缺陷的结构和功能网络异常。有了这样的认识，她计划开展一次新颖的演讲制作培训 研究奖项的R00阶段。所提出的语音训练游戏使用映射到声学输入的视觉光标，以便参与者可以使用他们的声音将光标移动到视觉目标。目标将对应于给定语音的产生，例如“bed”中的“e”。这种训练为检测目标偏差提供了第二个感官反馈来源。通过训练失语症患者学习使用视觉反馈击中声音目标，尼齐奥莱克博士的目标是使用完整的系统（视觉）来重新训练受损的系统（听觉检测）。她的长期目标是结合使用这种范例与神经标记物评估来开发针对每个患者的特定功能缺陷（听觉检测或运动矫正）的个性化治疗。这项研究职业发展计划将在波士顿大学与一个令人印象深刻的共同导师团队一起进行，她将从他们那里获得宝贵的临床和技术培训，最终目标是开发一个可以扩展到其他言语障碍的转化研究项目。