Initial Stages of Olfactory Information Processing
嗅觉信息处理的初始阶段
基本信息
- 批准号:9288136
- 负责人:
- 金额:$ 31.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-06 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAnatomyAnimalsBehaviorBehavioralBehavioral AssayBiophysicsBrain regionCaliberCellsCerebellumCommunicationComplexCourtshipCuesDataDiseaseDisease VectorsDrosophila genusDrosophila melanogasterElectron MicroscopyElectrophysiology (science)EngineeringFaceFoodGeneticGoalsHealthHippocampus (Brain)HumanImaging technologyIndividualInsect ControlInsect VectorsInsectaInvestigationLeadLogicMalariaMammalsMediatingModelingMolecular GeneticsMorphologyNeuronsOdorsOlfactory NerveOlfactory PathwaysOlfactory Receptor NeuronsPheromonePhysiologicalPopulationPrevalenceProcessPropertyResearchResearch DesignResistanceRetinaRoleSensory HairShapesSmell PerceptionStimulusSurveysSynapsesSystemTestingTissuesTransgenic OrganismsWorkbehavior influencebehavioral responsedesigndisorder controlextracellularflygenetic analysisimage reconstructioninformation processinginsightneural circuitneuronal cell bodynoveloptogeneticsrelating to nervous systemsensory systemvector control
项目摘要
PROJECT SUMMARY/ABSTRACT
The long-term goal of this project is to reveal the mechanisms by which complex odors are encoded, with a
special focus on the initial stages of olfactory information processing. The research design takes advantage of
the anatomical simplicity and powerful genetic toolkit of Drosophila melanogaster, which allows systematic
molecular genetic analysis of olfactory circuits as well as in-depth physiological and behavioral analysis of
olfactory function. The results may have major implications for the control of insect vectors of disease.
The project focuses on ephaptic interactions, a novel, non-synaptic form of olfactory circuit communication,
which take place between any two grouped olfactory receptor neurons (ORNs) housed in the same insect
sensory hair (sensillum). Despite its ubiquity, how ephaptic communication regulates olfactory function and
behavior is poorly understood. We recently provided the first description of the importance of ephaptic
inhibition in insect olfaction. In the current study, we will first focus on defining the importance of ephaptic
excitation. A systematic, functional survey will be performed to define the strength of ephaptic excitation
between grouped ORNs (Aim 1). The respective electrotonic properties of grouped ORNs will also be
determined (Aim 2). The strength of ephaptic interactions will be quantified between a pair of ORNs from both
directions with a view to testing the hypothesis that ephaptic interactions are asymmetric across sensillum
types. Furthermore, the ultrastructure of grouped ORNs will be described using serial block-face electron
microscopy (SBEM) and 3D reconstruction imaging technologies (Aim 3). This Aim is designed to identify the
biophysical factors that underlie asymmetric ephaptic interactions in a sensillum. Morphological features of an
identified ORN, such as dendritic caliber, number of dendritic branches, as well as soma size, will be analyzed
and compared between neighboring ORNs. The hypothesis that the physically larger ORN in a pair exerts
stronger ephaptic interactions upon its neighbor will be tested. This Aim could also lead to critical technical
breakthroughs to broaden the application of SBEM in illuminating the 3D ultrastructure of any identified cell in
diverse tissues. Lastly, the functional importance of ephaptic interactions in odor-guided behavior will be
determined (Aim 4). Specifically, we will extend our behavioral assay and define the role of ephaptic inhibition
on courtship behavior in sensillum which houses ORNs responsive to pheromone cues. We will also perform
the first test of the functional importance of ephaptic excitation between another ORN pair that mediates
behavioral responses to food odors.
The proposed research will determine the functional importance and biophysical principles of a novel form of
olfactory circuit interaction mechanism. These findings have the potential to revolutionize our understanding of
olfactory information processing in insects, and may reveal general principles that govern chemosensory
behavior throughout the animal kingdom.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Chih-Ying Su其他文献
Chih-Ying Su的其他文献
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{{ truncateString('Chih-Ying Su', 18)}}的其他基金
The relationship between spike response and calcium fluorescent signal in insect olfactory receptor neurons
昆虫嗅觉受体神经元尖峰反应与钙荧光信号的关系
- 批准号:
10429604 - 财政年份:2022
- 资助金额:
$ 31.95万 - 项目类别:
The relationship between spike response and calcium fluorescent signal in insect olfactory receptor neurons
昆虫嗅觉受体神经元尖峰反应与钙荧光信号的关系
- 批准号:
10552644 - 财政年份:2022
- 资助金额:
$ 31.95万 - 项目类别:
Analysis of sensory dendrite morphology and its impact on olfactory sensitivity
感觉树突形态分析及其对嗅觉敏感度的影响
- 批准号:
10651870 - 财政年份:2022
- 资助金额:
$ 31.95万 - 项目类别:
Analysis of sensory dendrite morphology and its impact on olfactory sensitivity
感觉树突形态分析及其对嗅觉敏感度的影响
- 批准号:
10510403 - 财政年份:2022
- 资助金额:
$ 31.95万 - 项目类别:
The organizing principle of grouped olfactory receptor neurons
分组嗅觉受体神经元的组织原理
- 批准号:
10197096 - 财政年份:2020
- 资助金额:
$ 31.95万 - 项目类别:
The organizing principle of grouped olfactory receptor neurons
分组嗅觉受体神经元的组织原理
- 批准号:
10042930 - 财政年份:2020
- 资助金额:
$ 31.95万 - 项目类别:
Genetic analysis of sexually dimorphic olfactory processing
两性嗅觉处理的遗传分析
- 批准号:
9376656 - 财政年份:2017
- 资助金额:
$ 31.95万 - 项目类别:
Genetic analysis of sexually dimorphic olfactory processing
两性嗅觉处理的遗传分析
- 批准号:
10189546 - 财政年份:2017
- 资助金额:
$ 31.95万 - 项目类别:
Genetic analysis of state-dependent chemosensory processing
状态依赖性化学感应处理的遗传分析
- 批准号:
10585464 - 财政年份:2017
- 资助金额:
$ 31.95万 - 项目类别:
Genetic analysis of state-dependent chemosensory processing
状态依赖性化学感应处理的遗传分析
- 批准号:
10708967 - 财政年份:2017
- 资助金额:
$ 31.95万 - 项目类别:
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