Pro-thrombotic Microparticles Generated by Pediatric Cardiopulmonary Bypass
儿科心肺转流术产生的促血栓微粒
基本信息
- 批准号:9268044
- 负责人:
- 金额:$ 18.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAnatomyAttenuatedAwardBiologicalBiological AssayBloodBlood CirculationBlood PlateletsBlood specimenCardiacCardiopulmonary BypassCaringCellsChildChild SupportChildhoodClinicalClinical ResearchCoagulation ProcessCongenital Heart DefectsCritical CareCritically ill childrenDataDefectDevelopmentDevicesDiagnosticEventFamily suidaeFibrinGenerationsGoalsHeart DiseasesHemorrhageHumanIn VitroInflammatoryInterventionKnowledgeLeadLifeLimb structureLung diseasesMaintenanceMembraneMentored Patient-Oriented Research Career Development AwardModelingMorbidity - disease rateNational Heart, Lung, and Blood InstituteNeonatalNeurologicOperative Surgical ProceduresOrgan failurePathway interactionsPatientsPhysiciansPrevalencePumpResearchResearch PersonnelRoleScientistStressStrokeTechnologyTherapeuticThrombelastographyThrombinThromboembolismThrombosisTimeUnited States National Institutes of HealthVesicleWhole Bloodblood pumpcareer developmentclinically relevantexperienceimprovedin vitro Modelinnovationmonocytemortalitypediatric patientsprogramspublic health relevancerepairedshear stressskillstranslational scientist
项目摘要
DESCRIPTION (provided by applicant): My long-term goal is to become a pediatric critical care physician-scientist, a translational researcher committed to eliminate complications from advanced technology used to support critically ill children. My current emphasis is to focus on the pathophysiological basis of the untoward effects of cardiopulmonary bypass (CPB) devices on blood components. The Mentored Patient-Oriented Research Career Development Award (K23) will provide me with time to gather skills and knowledge as a necessary steps toward becoming an established, independent investigator. Over the past sixty years, support by Cardiopulmonary Bypass devices (CPB) has led to significant decreases in the mortality and morbidity of children suffering from life threatening heart or lung diseases. Although pump- related hemorrhage can be attenuated by maintenance of platelet levels, pump-dependent platelet and monocyte activation can lead to devastating stroke. This can be explained by the flow rates generated in extracorporeal blood pumps that increase the applied shear stress, this activates circulating monocytes and platelets. These activated cells will release platelet- and monocyte-derived microparticles (PMPs & MoMPs), small (0.1-1 micron) cell-derived membrane vesicles. PMPs and MoMPs released by applied shear stress may further contribute to thromboembolism by inducing a pro-thrombotic and pro-inflammatory state. My previous studies document the release of PMPs in an in vitro pediatric cardiopulmonary bypass circuit using porcine whole blood. We hypothesize that increased shear stress generated by a pediatric extracorporeal blood pump promotes pro-thrombotic microparticle release. This award will provide me with dedicated time to obtain new research skills in thrombosis and coagulation assays and experience in conducting pediatric studies. The goals of this research is to define how pump-produced PMPs and MoMPs contribute to thrombosis, from a pediatric model of CPB and from pediatric patients supported by CPB, in order to understand the mechanisms and subsequent therapeutics to address extracoporeal blood pump related thrombotic complications.
描述(由申请人提供):我的长期目标是成为一名儿科重症监护内科科学家,一名致力于消除用于支持危重儿童的先进技术的并发症的翻译研究人员。我目前的重点是关注体外循环(CPB)装置对血液成分产生不良影响的病理生理学基础。以患者为导向的导师研究职业发展奖(K23)将为我提供时间来收集技能和知识,作为成为一名成熟的、独立的研究人员的必要步骤。在过去的60年里,在体外循环装置(CPB)的支持下,患有危及生命的心脏或肺部疾病的儿童的死亡率和发病率显著下降。尽管泵相关出血可以通过维持血小板水平来减少,但泵依赖的血小板和单核细胞激活可能导致毁灭性的中风。这可以用体外血泵产生的流速来解释,它增加了所施加的剪应力,从而激活了循环中的单核细胞和血小板。这些激活的细胞将释放血小板和单核细胞来源的微粒(PMPs和MoMPs),即小的(0.1-1微米)细胞来源的膜泡。外加剪应力释放的PMPs和MoMPs可能通过诱导血栓前状态和炎症状态进一步促进血栓栓塞症。我以前的研究记录了PMPs在使用猪全血的体外儿科体外循环循环中的释放。我们假设,儿科体外血泵产生的剪切力增加会促进血栓前微粒的释放。这一奖项将为我提供专门的时间,以获得血栓形成和凝血分析方面的新研究技能,以及进行儿科研究的经验。本研究的目的是从体外循环的儿科模型和CPB支持的儿科患者中确定泵产生的PMPs和MoMPs如何促进血栓形成,以了解其机制和后续治疗方法,以解决体外循环血泵相关的血栓并发症。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Andrew Duncan Joseph Meyer其他文献
Andrew Duncan Joseph Meyer的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Andrew Duncan Joseph Meyer', 18)}}的其他基金
Pro-thrombotic Microparticles Generated by Pediatric Cardiopulmonary Bypass
儿科心肺转流术产生的促血栓微粒
- 批准号:
9114153 - 财政年份:2015
- 资助金额:
$ 18.99万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 18.99万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 18.99万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 18.99万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 18.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 18.99万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 18.99万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 18.99万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 18.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 18.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 18.99万 - 项目类别:
Grant-in-Aid for Scientific Research (C)