2017 Modulation of Neural Circuits & Behavior Gordon Research Conference

2017年神经回路的调制

• 批准号: 9393612
• 负责人: JOY A ALCEDO
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9393612
• 关键词: Address; Aging; Animal Behavior; Animal Model; Asia; Australia; Behavior; Behavioral; Biological; Brain; Cognitive deficits; Collaborations; Communities; Complex; Country; Cues; Developing Countries; Disease; Emotional disorder; Environment; Europe; Evolution; Food; Fostering; Future; Generations; Genetic; Growth; Homeostasis; Hong Kong; Human; Impaired cognition; Individual; Institutes; Invertebrates; Knowledge; Lead; Learning Disabilities; Maine; Mental Depression; Mentors; Mentorship; Minority; Mission; National Institute of Child Health and Human Development; National Institute of Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Neurons; Participant; Physiological Processes; Process; Recruitment Activity; Request for Proposals; Research; Research Personnel; Role; Scientist; Senior Scientist; Shapes; Sister; Sleep; Social Behavior; Students; System; Woman; Work; addiction; career; career development; combat; information processing; insight; meetings; member; nervous system disorder; neural circuit; neuroregulation; non-genetic; programs; relating to nervous system; response; sex; symposium; synergism

Summary This proposal requests R13 support for the second meeting of the Gordon Research Conference (GRC) on Modulation of Neural Circuits & Behavior: Origins and Diversity of Neuromodulatory Mechanisms that Serve Basic Biological Needs, to be held on June 4-9, 2017, in Newry, Maine. Understanding how the human brain works will require more than the mapping of neural connectivities, because the information processing at each neuronal connection will depend on the interplay among many external and internal factors. Such modulatory mechanisms can drastically enhance or dampen distinct types of neural processes and animal behaviors in response to different environmental cues. Not surprisingly, modulators have been implicated in many neurological disorders that range from learning disabilities, addiction and depression to the cognitive decline associated with aging-related diseases. Thus, neuromodulation is necessary to promote neuronal homeostasis and optimize the individuals' survival in changing environments, which would drive the evolution of neural circuit diversity. The successful first GRC meeting on neuromodulation in Hong Kong, in 2015, brought together scientists from the US and non-US countries. The second meeting in Maine in 2017 will continue to provide a much-needed forum to better achieve the integration of concepts highlighted in different vertebrate and invertebrate systems studied by scientists on different continents. Thus, this forum will provide a global perspective of the diversity and conserved common principles in evolution for the role of neuromodulation in physiological processes and behavioral expression. This second meeting will focus on the origin and evolution of neuromodulation in serving basic biological needs, such as food, sleep, sex, and complex social behaviors, since mechanistic insights into its origins and evolution should allow us to understand how neuromodulation can arise in different contexts and promote healthy brain function. This meeting is unique, since it brings together scientists from disparate fields to foster collaborative ideas and activities in the synthesis of the common principles of neuromodulation. This will be facilitated by specific sections of the program devoted to general discussions that will cover the presentations that address the common themes of each day. More importantly, our second meeting will have an overall general discussion during the closing session, which will integrate all the diverse findings presented at the meeting, thus further advancing our understanding of neuromodulation and its importance in healthy brain function. Finally, this meeting will feature participants of different generations, with a proper representation of early pioneering investigators, current leaders and junior investigators, providing an opportunity for intimate exchanges of knowledge and ideas. Together these should drive promising future directions in the study of neuromodulation, which should be in line with the mission of NINDS and its sister institutes, NIDA, NICHD, NIA and NIDCD.

总结 本提案要求R13支持戈登研究会议（GRC）第二次会议， 神经回路和行为的调制：神经调节机制的起源和多样性， 服务于基本的生物需求，将于2017年6月4日至9日在纽里举行，缅因州。了解人类如何 大脑工作需要的不仅仅是神经连接的映射，因为信息处理在 每一个神经元连接都依赖于许多外部和内部因素之间的相互作用。等 调节机制可以显著地增强或抑制不同类型的神经过程和动物神经系统。 不同的环境线索的反应。毫不奇怪，调节剂与 许多神经系统疾病，范围从学习障碍，成瘾和抑郁症的认知 与衰老有关的疾病。因此，神经调节对于促进神经元 自我平衡和优化个体在不断变化的环境中的生存，这将推动 神经回路多样性 2015年在香港成功举办了第一届神经调节GRC会议， 美国和非美国国家。2017年在缅因州举行的第二次会议将继续提供急需的 论坛，以更好地实现不同脊椎动物和无脊椎动物系统中强调的概念的整合 不同大陆的科学家们研究过。因此，这个论坛将提供一个多样性的全球视角， 和保守的共同原则，在进化中的作用，神经调节在生理过程中， 行为表达这第二次会议将集中在起源和进化的神经调制在服务 基本的生物需求，如食物，睡眠，性和复杂的社会行为，因为机械的见解， 它的起源和进化应该让我们了解神经调节如何在不同的环境中出现， 促进健康的大脑功能。 这次会议是独一无二的，因为它汇集了来自不同领域的科学家，以促进合作的想法 以及神经调节的共同原理的合成中的活动。这将有助于具体的 该计划的部分专门用于一般性讨论，将涵盖解决 每天的共同主题。更重要的是，我们的第二次会议将进行全面的一般性讨论 闭幕会议将综合会议上提出的各种结果，从而进一步 促进我们对神经调节及其在健康大脑功能中的重要性的理解。最后 会议将以不同世代的参与者为特色，并适当代表早期开拓者 调查人员、现任领导人和初级调查人员，提供了一个密切交流的机会， 知识和思想。这些应该共同推动神经调节研究中有前途的未来方向， 这应符合NINDS及其姊妹机构NIDA、NICHD、NIA和NIDCD的使命。