Improved pulse oximetry performance using transmission optical flowmetry.

项目摘要 自1981年其商业引入以来，脉搏血氧饱和度测定法已成为广泛采用的测量方法。 手术室、重症监护室和医院病房的护理标准。的能力 使用脉搏血氧仪测量动脉血氧饱和度非常有用， 生命体征”。尽管脉搏血氧仪无处不在，但它们受到两个基本限制 自成立以来：当患者经历血管收缩时信号质量差，以及 由运动引起的错误数据。虽然先进的信号处理技术已经 商业上使用，以解决这些问题，错误的警报，导致工作人员的工作量增加 以及警惕性降低（“警报疲劳”）仍然非常普遍。 拟议研究的长期目标是开发下一代 脉搏血氧计，其通过执行动脉血液氧合来解决上述局限性 以新的和根本上不同于光电体积描记的方式测量 今天使用的方法。所提出的方法利用已建立的血流测量 基于光散射的技术来执行测量，这导致 通常比典型的脉搏血氧计信号大几百倍 易受血管收缩和运动的影响。 这一长期目标将通过以下三个具体目标来实现： 将多波长VCSEL光源集成到已建立的夹式血液流量计中， (2)通过与台式血液进行比较，在家兔模型中验证该多波长仪器 氧气挑战期间的气体分析，以及（3）完成与 使用收集的经验数据结合 蒙特卡罗模拟。目标1将通过修改已经存在的仪器来实现 由PI开发，用于通过以下方式制造的多波长光源测量血流 一个商业伙伴。目标2将通过与贝克曼的密切合作来实现 激光研究所和他们建立的兽医团队谁执行光子为基础的小动物 每天学习。目标3将通过利用经验证的光传播建模工具来实现， 根据目标2中收集的数据创建一个强大的查找表。

Project Summary Since its commercial introduction in 1981, pulse oximetry has become a widely adopted standard of care in operating rooms, intensive care units, and hospital wards. The ability to measure arterial oxygen saturation using pulse oximetry is so useful that it is considered the “5th vital sign”. Despite their ubiquity, pulse oximeters have suffered from two fundamental limitations since their inception: poor signal quality when patients experience vasoconstriction, and erroneous data caused by motion. Although advanced signal processing techniques have been use commercially to address these problems, false alarms that lead to increased staff workload and decreased vigilance (“alarm fatigue”) remain very common. The long-term goal of the proposed research is the development of a next-generation pulse oximeter which addresses the limitations above by performing arterial blood oxygenation measurements in new and fundamentally different manner than the photoplethysmographic methods used today. The proposed method leverages established blood flow measurement techniques based on light scattering to perform measurements, which results in a signal that is often hundreds of times greater than a typical pulse oximeter signal and which is significantly less susceptible to vasoconstriction and motion. This long-term goal will be achieved by pursuing the following three specific aims: (1) integrating a multi-wavelength VCSEL light source into an established clip-on blood flowmeter, (2) validating this multi-wavelength instrument in a rabbit model via comparison to bench top blood gas analysis during an oxygen challenge, and (3) completing a formal framework for relating SpO2 to measured blood flow waveforms using collected empirical data from in conjunction with Monte Carlo simulations. Aim 1 will be accomplished by modifying instrumentation already developed by the PI to measure blood flow with multi-wavelength light sources fabricated through a commercial partner. Aim 2 will be accomplished through close collaboration with the Beckman Laser Institute and their established veterinary team who performs photonics-based small animal studies daily. Aim 3 will be accomplished by utilizing validated light propagation modeling tools to create a robust lookup table based generated from the data collected in Aim 2.