Neurobehavioral Characterization of Social Influence in Drug Addiction

描述（由申请人提供）：Gilman博士目前是哈佛医学院（HMS）精神病学系和马萨诸塞州总医院（MGH）Martinos生物医学成像中心的博士后研究员。拟议的K 01将为她提供先进的培训和指导的研究经验，这将使她准备建立一个独立的研究线，研究在药物滥用的背景下社会决策的神经科学。她的目标是指导一个实验室，使用多模态成像和行为和心理测试，以了解药物滥用的生物，心理和临床方面。具体来说，她感兴趣的是使用脑成像来了解社会影响在不同阶段的药物使用中的作用， 易受社会影响，并测试是否易受社会影响是一个危险因素的发展物质使用障碍。在丰富的环境中与优秀的指导团队进行高级培训，将使她能够作为一名独立的科学家进入下一阶段。在获奖期间，Gilman博士将实现以下目标：1）发展社会影响/群体动态如何影响奖励和决策过程的专业知识，2）加强对药物使用的神经生物学/药理学的理解，并将研究融入临床环境，3）通过加强统计培训，发展先进的计算机技能，和发展与多模式数据集的工作的专业知识，以及（4）进行专业培训，在负责任的研究行为。在K 01期间，Gilman博士将进行一个创新项目，药物成瘾中社会影响的神经行为表征，她将使用新开发的社会影响任务来表征早期药物使用中社会影响的行为和神经相关性。这个K奖将补充她在神经成像，奖励电路和神经药理学方面的现有优势，并在社会影响，神经生物学和药物使用的临床方面以及计算机，统计和多模态成像技能方面进行培训，并将为她作为一名富有成效的成瘾科学家的独立职位做好准备。

DESCRIPTION (provided by applicant): Dr. Gilman is currently a postdoctoral research fellow at Harvard Medical School (HMS) Department of Psychiatry and the Massachusetts General Hospital (MGH) Martinos Biomedical Imaging Center. The proposed K01 will provide her with advanced training and mentored research experience that will prepare her to establish an independent line of research examining the neuroscience of social decision-making in the context of substance abuse. Her goal is to direct a laboratory that uses multi-modal imaging and behavioral and psychological testing to understand the biological, psychological, and clinical aspects of drug abuse. Specifically, she is interested in using brain imaging to understand the role of social influence in different stages of drug use, to characterize individual differences in susceptibility to social influence, and to test if susceptibility to social influence is a risk facor for the development of substance use disorders. Advanced training with an exceptional mentoring team in a rich environment will enable her to advance to the next stage as an independent scientist. During the award period, Dr. Gilman will achieve the following aims: 1) Develop expertise in how social influence/group dynamics affect reward and decision-making processes, 2) Enhance understanding of the neurobiology/pharmacology of drug use, and integrate research into a clinical setting, 3) Increase her potential for independence by enhancing statistical training, developing advanced computer skills, and developing expertise in working with multi-modal data sets, and (4) Undertake specialized training in the responsible conduct of research. In the K01 period, Dr. Gilman will conduct an innovative project, Neurobehavioral Characterization of Social Influence in Drug Addiction, in which she will use a newly- developed social influence task to characterize behavior and neural correlates of social influence in early drug use. This K award will complement her existing strengths in neuroimaging, reward circuitry, and neuropharmacology, with training in social influence, neurobiology and clinical aspects of drug use, as well as in computer, statistical, and multimodal imaging skills, and will prepare her for an independent position as a productive addiction scientist.