Neurobehavioral Characterization of Social Influence in Drug Addiction

描述(申请人提供)：吉尔曼博士目前是哈佛医学院(HMS)精神病学系和马萨诸塞州总医院(MGH)Martinos生物医学成像中心的博士后研究员。拟议的K01将为她提供高级培训和有指导的研究经验，使她做好准备，建立一条独立的研究路线，在药物滥用的背景下审查社会决策的神经科学。她的目标是领导一个使用多模式成像以及行为和心理测试的实验室，以了解药物滥用的生物、心理和临床方面。具体地说，她感兴趣的是使用大脑成像来了解社会影响在药物使用的不同阶段所起的作用，以表征个体在 对社会影响的敏感性，并测试对社会影响的敏感性是否是发展成物质使用障碍的风险因素。在丰富的环境中接受卓越的指导团队的高级培训将使她能够作为一名独立科学家进入下一阶段。在获奖期间，吉尔曼博士将实现以下目标：1)开发社会影响/群体动态如何影响奖励和决策过程的专业知识；2)加强对药物使用的神经生物学/药理学的了解，并将研究整合到临床环境中；3)通过加强统计培训、发展先进的计算机技能和开发使用多模式数据集的专业知识，提高她的独立性潜力；以及(4)进行负责任的研究工作的专门培训。在K01期间，吉尔曼博士将进行一个创新的项目，即吸毒成瘾社会影响的神经行为表征，在该项目中，她将使用一个新开发的社会影响任务来表征早期吸毒中社会影响的行为和神经相关性。这项K奖项将补充她在神经成像、奖赏电路和神经药理学方面的现有优势，并接受社会影响、神经生物学和药物使用的临床方面的培训，以及计算机、统计学和多模式成像技能，并将为她作为一名高效成瘾科学家的独立职位做好准备。

DESCRIPTION (provided by applicant): Dr. Gilman is currently a postdoctoral research fellow at Harvard Medical School (HMS) Department of Psychiatry and the Massachusetts General Hospital (MGH) Martinos Biomedical Imaging Center. The proposed K01 will provide her with advanced training and mentored research experience that will prepare her to establish an independent line of research examining the neuroscience of social decision-making in the context of substance abuse. Her goal is to direct a laboratory that uses multi-modal imaging and behavioral and psychological testing to understand the biological, psychological, and clinical aspects of drug abuse. Specifically, she is interested in using brain imaging to understand the role of social influence in different stages of drug use, to characterize individual differences in susceptibility to social influence, and to test if susceptibility to social influence is a risk facor for the development of substance use disorders. Advanced training with an exceptional mentoring team in a rich environment will enable her to advance to the next stage as an independent scientist. During the award period, Dr. Gilman will achieve the following aims: 1) Develop expertise in how social influence/group dynamics affect reward and decision-making processes, 2) Enhance understanding of the neurobiology/pharmacology of drug use, and integrate research into a clinical setting, 3) Increase her potential for independence by enhancing statistical training, developing advanced computer skills, and developing expertise in working with multi-modal data sets, and (4) Undertake specialized training in the responsible conduct of research. In the K01 period, Dr. Gilman will conduct an innovative project, Neurobehavioral Characterization of Social Influence in Drug Addiction, in which she will use a newly- developed social influence task to characterize behavior and neural correlates of social influence in early drug use. This K award will complement her existing strengths in neuroimaging, reward circuitry, and neuropharmacology, with training in social influence, neurobiology and clinical aspects of drug use, as well as in computer, statistical, and multimodal imaging skills, and will prepare her for an independent position as a productive addiction scientist.