The Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)

心、肺和血液特征的遗传流行病学培训补助金 (GenHLB)

• 批准号: 9260933
• 负责人: KAREN L. MOHLKE
• 金额: $ 24.47万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9260933
• 关键词: Blood; Grant; Heart; Lung; genetic epidemiology

 DESCRIPTION (provided by applicant): Human genome studies are providing fresh insights into heart, lung, and blood (HLB) traits, with opportunities for translation of research findings t clinical and community settings for disease prevention and health promotion. Yet, there remain an insufficient number of HLB genetic epidemiologists who can design and implement multidisciplinary HLB genetic epidemiology research that combines technological advances in genome measurement with cutting-edge statistical tools to advance understanding of the genomic basis of HLB traits and associated diseases in the most-burdened populations. The Genetic Epidemiology of Heart, Lung, and Blood Traits (or GenHLB) Training Grant responds to these research gaps by providing interdisciplinary, integrated, and comprehensive instruction in the genetic epidemiology of HLB traits from an outstanding team of research mentors with expertise spanning four proposed training dimensions: HLB genetic epidemiology; computation/methods; `OMICs; and culture, diversity, and disparities. The Training Program will encompass formal didactics based on an individual development plan; tailored mentorship; research experiences in two training dimensions; presentations; manuscript and grant preparation; research seminars and colloquia; and instruction in the responsible conduct of research. The GenHLB training program also will include careful evaluation of the quality and effectiveness of the Training Program, ensuring that fellows achieve the competencies and skills necessary for success as future HLB genetic epidemiology research leaders. The five-year program aims to support four (two pre-doctoral and two postdoctoral) fellows at initiation, increasing to six (three pre-doctoral and three postdoctoral) fellows in year 03. Among the postdoctoral fellows, prior expertise in epidemiology, human genetics, biostatistics, bioinformatics, computational biology, medicine, and applied mathematics will be sought. Pre-doctoral fellows will be required to pursue a doctoral degree in epidemiology, specializing in HLB genetic epidemiology. Our selection of internationally known research mentors with established research collaborations, unique and multidisciplinary training environment, and unparalleled research opportunities make us exceptionally well-positioned to lead this novel training program and develop the next generation of genetic epidemiology leaders who are well-equipped to investigate the genetic underpinnings of HLB traits and associated diseases.

 描述（由申请人提供）：人类基因组研究为心脏、肺和血液（HLB）性状提供了新的见解，并有机会将研究结果转化为临床和社区环境，用于疾病预防和健康促进。然而，仍然有足够数量的HLB遗传流行病学家，他们可以设计和实施多学科的HLB遗传流行病学研究，将基因组测量的技术进步与尖端的统计工具相结合，以促进对HLB性状和相关疾病的基因组基础的理解。心脏的遗传流行病学，肺，和血液性状（或GenHLB）培训补助金通过提供HLB性状遗传流行病学的跨学科，综合和全面的指导来应对这些研究差距，这些指导来自一个优秀的研究导师团队，他们的专业知识涵盖四个拟议的培训维度：HLB遗传流行病学;计算/方法; `OMIC;和文化，多样性和差异。培训计划将包括基于个人发展计划的正式教学法;量身定制的导师;两个培训维度的研究经验;演讲;手稿和赠款准备;研究研讨会和座谈会;以及负责任地进行研究的指导。GenHLB培训计划还将包括对培训计划的质量和有效性进行仔细评估，确保研究员获得成功所需的能力和技能，成为未来HLB遗传流行病学研究的领导者。五年计划的目的是支持四个（两个博士前和两个博士后）研究员在启动，增加到六个（三个博士前和三个博士后）研究员在03年。在博士后研究员中，将寻求流行病学，人类遗传学，生物统计学，生物信息学，计算生物学，医学和应用数学方面的专业知识。博士前研究员将被要求攻读流行病学博士学位，专门从事HLB遗传流行病学。我们选择国际知名的研究导师，建立研究合作，独特和多学科的培训环境，以及无与伦比的研究机会，使我们非常有能力领导这个新的培训计划，并培养下一代遗传流行病学领导者，他们有能力调查HLB性状和相关疾病的遗传基础。