The Genetic Epidemiology of Heart, Lung, and Blood Traits Training Grant (GenHLB)

摘要 人类基因组研究继续提供对心、肺和血液(HLB)特征的新见解， 将研究成果转化为预防疾病和促进健康的机会。然而，一个不充分的 多名HLB遗传流行病学家可以设计和实施多学科HLB遗传流行病学 将基因组学技术进步与尖端统计工具相结合的研究 了解不同群体的HLB性状和相关疾病的遗传基础。基因 心、肺和血液特征流行病学(或GenHLB)培训基金通过以下方式解决这些研究空白 提供跨学科的、综合的、全面的HLB性状遗传流行病学指导 来自一支优秀的研究导师团队，他们的专业知识横跨四个培训维度：HLB Genetic 流行病学；计算方法；‘OMIC；以及文化、多样性和差异。培训计划 包括基于个人发展计划的正式教学、量身定做的指导、两个阶段的研究 培训层面、专题介绍、手稿和赠款准备、研究研讨会和座谈会，以及 指导负责任的研究和研究的严密性和可重复性。GenHLB培训 方案还包括仔细评估方案的质量和有效性，确保研究员 获得成功所需的能力和技能，作为未来的人类免疫缺陷遗传流行病学研究 领袖们。本次续签申请建议继续支持三名博士后和三名博士后 每年都有研究员参加。博士后研究员具有流行病学、人类遗传学、生物统计学、 生物信息学、计算生物学或医学，并获得跨学科培训。博士前研究员继续 流行病学博士，专攻人类免疫缺陷遗传流行病学，并接受过第二领域的培训。两位申请人均为 泳池具有很高的选择性。在我们的第一个资助周期中，我们项目培训的11名研究员成功地 进行跨学科研究，在领先期刊上发表，获得独立资金，并获得 质疑HLB性状遗传流行病学的竞争性立场。在未来五年，我们建议 对计算培训维度的扩展，以包括对因果推理和研究的关注 精准医学的主题。具体地说，我们包括在因果推理方面具有专业知识的教师，并添加了 精准医学的课程作业和实习经验。加强对肺和血液特征的关注， 领导力培训，并参加跨学科公共卫生专业发展研讨会 并提出了一系列的解决方案。我们的计划由国际知名的研究导师组成，拥有成熟的研究 协作、独特的多学科培训环境以及大量的研究机会 美国处于异常有利的地位，可以继续培养下一代遗传流行病学领导者 都有很好的设备来研究HLB特征和相关疾病的遗传基础。

ABSTRACT Human genome studies continue to provide new insights into heart, lung, and blood (HLB) traits, with opportunities for translation of research findings for disease prevention and health promotion. Yet, an insufficient number of HLB genetic epidemiologists can design and implement multidisciplinary HLB genetic epidemiology studies that combine technological advances in genomics with cutting-edge statistical tools to advance understanding of the genetic basis of HLB traits and associated diseases across populations. The Genetic Epidemiology of Heart, Lung, and Blood Traits (or GenHLB) Training Grant addresses these research gaps by providing interdisciplinary, integrated, and comprehensive instruction in the genetic epidemiology of HLB traits from an outstanding team of research mentors with expertise spanning four training dimensions: HLB genetic epidemiology; computational methods; `OMICs; and culture, diversity, and disparities. The training program encompasses formal didactics based on an individual development plan, tailored mentorship, research in two training dimensions, presentations, manuscript and grant preparation, research seminars and colloquia, and instruction in the responsible conduct of research and research rigor and reproducibility. The GenHLB training program also includes careful evaluation of the quality and effectiveness of the program, ensuring that fellows achieve the competencies and skills necessary for success as future HLB genetic epidemiology research leaders. This renewal application proposes continued support of three pre-doctoral and three postdoctoral fellows each year. Postdoctoral fellows have prior expertise in epidemiology, human genetics, biostatistics, bioinformatics, computational biology, or medicine and gain interdisciplinary training. Pre-doctoral fellows pursue a PhD in epidemiology, specializing in HLB genetic epidemiology with a second area of training. Both applicant pools are highly selective. During our first cycle of funding, the 11 fellows trained by our program successfully conducted transdisciplinary research, published in leading journals, secured independent funding, and obtained competitive positions interrogating the genetic epidemiology of HLB traits. For the next five years, we propose an expansion of the computational training dimension to include a focus on causal inference and a research theme of precision medicine. Specifically, we include faculty with expertise in causal inference and added coursework and practicum experiences in precision medicine. An enhanced focus on lung and blood traits, leadership training, and participation in an interdisciplinary public health professional development seminar series also is proposed. Our program of internationally known research mentors with established research collaborations, unique and multidisciplinary training environment, and a multitude of research opportunities make us exceptionally well-positioned to continue training the next generation of genetic epidemiology leaders who are well-equipped to investigate the genetic underpinnings of HLB traits and associated diseases.