The Genetic Epidemiology of Heart, Lung, and Blood Traits Training Grant (GenHLB)

心肺和血液性状遗传流行病学培训补助金 (GenHLB)

• 批准号: 10642715
• 负责人: KAREN L. MOHLKE
• 金额: $ 42.73万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642715
• 关键词: Blood; Grant; Heart; Lung; Training; genetic epidemiology; trait

ABSTRACT Human genome studies continue to provide new insights into heart, lung, and blood (HLB) traits, with opportunities for translation of research findings for disease prevention and health promotion. Yet, an insufficient number of HLB genetic epidemiologists can design and implement multidisciplinary HLB genetic epidemiology studies that combine technological advances in genomics with cutting-edge statistical tools to advance understanding of the genetic basis of HLB traits and associated diseases across populations. The Genetic Epidemiology of Heart, Lung, and Blood Traits (or GenHLB) Training Grant addresses these research gaps by providing interdisciplinary, integrated, and comprehensive instruction in the genetic epidemiology of HLB traits from an outstanding team of research mentors with expertise spanning four training dimensions: HLB genetic epidemiology; computational methods; `OMICs; and culture, diversity, and disparities. The training program encompasses formal didactics based on an individual development plan, tailored mentorship, research in two training dimensions, presentations, manuscript and grant preparation, research seminars and colloquia, and instruction in the responsible conduct of research and research rigor and reproducibility. The GenHLB training program also includes careful evaluation of the quality and effectiveness of the program, ensuring that fellows achieve the competencies and skills necessary for success as future HLB genetic epidemiology research leaders. This renewal application proposes continued support of three pre-doctoral and three postdoctoral fellows each year. Postdoctoral fellows have prior expertise in epidemiology, human genetics, biostatistics, bioinformatics, computational biology, or medicine and gain interdisciplinary training. Pre-doctoral fellows pursue a PhD in epidemiology, specializing in HLB genetic epidemiology with a second area of training. Both applicant pools are highly selective. During our first cycle of funding, the 11 fellows trained by our program successfully conducted transdisciplinary research, published in leading journals, secured independent funding, and obtained competitive positions interrogating the genetic epidemiology of HLB traits. For the next five years, we propose an expansion of the computational training dimension to include a focus on causal inference and a research theme of precision medicine. Specifically, we include faculty with expertise in causal inference and added coursework and practicum experiences in precision medicine. An enhanced focus on lung and blood traits, leadership training, and participation in an interdisciplinary public health professional development seminar series also is proposed. Our program of internationally known research mentors with established research collaborations, unique and multidisciplinary training environment, and a multitude of research opportunities make us exceptionally well-positioned to continue training the next generation of genetic epidemiology leaders who are well-equipped to investigate the genetic underpinnings of HLB traits and associated diseases.

摘要 人类基因组研究继续为心脏、肺和血液（HLB）性状提供新的见解， 为疾病预防和健康促进提供翻译研究成果的机会。然而，一个不足 许多HLB遗传流行病学家可以设计和实施多学科HLB遗传流行病学 将基因组学的联合收割机技术进步与尖端统计工具相结合， 了解HLB性状和相关疾病的遗传基础。遗传 心、肺和血液特征的流行病学（或GenHLB）培训补助金通过以下方式解决了这些研究空白： 在HLB性状的遗传流行病学方面提供跨学科，综合和全面的指导 来自优秀的研究导师团队，拥有涵盖四个培训维度的专业知识：HLB遗传学 流行病学;计算方法;“OMIC”;以及文化、多样性和差异。培训计划 包括基于个人发展计划的正式教学法、量身定制的指导、两阶段研究 培训方面、演讲、手稿和赠款准备、研究研讨会和座谈会，以及 在研究和研究的严谨性和可重复性的负责任的行为的指示。GenHLB培训 该计划还包括仔细评估计划的质量和有效性，确保研究员 获得成功所需的能力和技能，作为未来的HLB遗传流行病学研究 领导人的人选信号本次续签申请提出继续支持三名博士后和三名博士后 每年都有研究员。博士后研究员具有流行病学，人类遗传学，生物统计学， 生物信息学，计算生物学或医学，并获得跨学科的培训。博士前研究员追求 流行病学博士，专门从事HLB遗传流行病学与第二领域的培训。双方申请人 游泳池是高度选择性的。在我们的第一个资助周期，11名研究员成功地通过我们的计划培训， 进行跨学科研究，在领先期刊上发表，获得独立资助，并获得 竞争性的职位询问HLB性状的遗传流行病学。在接下来的五年里，我们建议 计算训练维度的扩展，包括对因果推理的关注和研究 精准医疗的主题。具体来说，我们包括教师与因果推理的专业知识，并补充说， 精准医学的课程和实习经验。加强对肺和血液特征的关注， 领导能力培训，并参加跨学科公共卫生专业发展研讨会 系列也提出了。我们的国际知名研究导师计划， 合作，独特和多学科的培训环境，以及众多的研究机会，使 我们非常有能力继续培训下一代遗传流行病学领导者， 有能力调查HLB性状和相关疾病的遗传基础。

项目成果

Early pregnancy phthalates and replacements in relation to fetal growth: The human placenta and phthalates study.

• DOI: 10.1016/j.envres.2023.115975
• 发表时间: 2023-04
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: D. Stevens;E. Rosen;Kimi Van Wickle;E. McNell;P. Bommarito;A. Calafat;J. Botelho;E. Sinkovskaya;Ann Przybylska;G. Saade;A. Abuhamad;K. Ferguson

Social integration and risk of mortality among African-Americans: the Jackson heart study.

• DOI: 10.1007/s00127-023-02485-1
• 发表时间: 2023-09
• 期刊: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
• 影响因子: 4.4
• 作者: Lee, Harold H.;Okuzono, Sakurako S.;Trudel-Fitzgerald, Claudia;James, Peter;Koga, Hayami K.;Sims, Mario;Grodstein, Francine;Kubzansky, Laura D.
• 通讯作者: Kubzansky, Laura D.

Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics.

• DOI: 10.1186/s12979-022-00278-9
• 发表时间: 2022-05-24
• 期刊: Immunity & ageing : I & A

HPTAD: A computational method to identify topologically associating domains from HiChIP and PLAC-seq datasets.

• DOI: 10.1016/j.csbj.2023.01.003
• 发表时间: 2023
• 期刊: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
• 影响因子: 6
• 作者: Rosen, Jonathan;Lee, Lindsay;Abnousi, Armen;Chen, Jiawen;Wen, Jia;Hu, Ming;Li, Yun
• 通讯作者: Li, Yun

Affective response to physical activity as a deep phenotype in a non-randomized pilot study.

• DOI: 10.1038/s41598-022-09662-3
• 发表时间: 2022-04-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Lee HH;McGeary JE;Dunsiger S;Emerson JA;Bock B;McCaffery J;Dwyer K;Bryan AD;Williams DM
• 通讯作者: Williams DM