Shanghai Womens Health Study

描述（由申请人提供）：上海妇女健康研究（SWHS，R37 CA070867）是一项基于人群的队列研究，招募了 1997 年至 2000 年间约 75,000 名中国女性，并通过多次现场调查进行跟踪，并记录与基于人群的登记的联系。多年来，SWMS 中收集的数据和生物样本已被用于评估许多重要的病因假设并支持多项研究，其中包括约 40 个研究联盟。为了维持和扩大 SWHS 资源并取得成功，我们正在申请基础设施资金。具体目标： 1) 继续对癌症发病率和特定原因死亡率进行队列随访，并进行额外的面对面访谈，以获得有关暴露和选定疾病结果的信息； 2）维护SWHS数据库和生物样本库，以支持研究并促进与科学界的数据共享； 3) 收集并储存约 40,000 名活着的队列成员的粪便样本，用于未来粪便微生物群和其他生物标志物的研究； 4) 通过与基于人群的电子医学数据库的链接，建立临床和药物流行病学研究资源； 5) 继续收集诊断为癌症的队列成员的肿瘤组织样本以研究肿瘤标志物。 SWHS 拥有庞大的样本量、丰富的资源以及独特的暴露模式和疾病谱，为解决许多在其他现有队列中无法充分研究的重要假设提供了绝佳的机会。 SWHS 的结果将对降低癌症和其他非传染性疾病的发病率和死亡率产生重大影响，这些疾病是大多数国家的主要死亡原因。

DESCRIPTION (provided by applicant): The Shanghai Women's Health Study (SWHS, R37 CA070867) is a population-based cohort study of approximately 75,000 Chinese women who were recruited between 1997 and 2000 and have been followed via multiple in-person surveys and record linkages with population-based registries. Over the years, data and biological samples collected in the SWMS have been used to evaluate many important etiologic hypotheses and support multiple studies, including about 40 research consortia. To sustain and expand SWHS resources and success, we are applying for infrastructure funding. Specific aims: 1) Continue cohort follow-up for cancer incidence and cause-specific mortality and conduct additional in-person interviews to obtain information regarding exposures and selected disease outcomes; 2) Maintain SWHS data bank and biorepository to support research and facilitate data sharing with the scientific community; 3) Collect and store stool samples from approximately 40,000 living cohort members for future research of fecal microbiota and other biomarkers; 4) Establish resources for clinical and pharmaco-epidemiologic research through linkage with population-based electronic medical databases; 5) Continue to collect tumor tissue samples among cohort members diagnosed with cancer to study tumor markers. The SWHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts. Results from the SWHS will have significant impact on reducing the incidence and mortality of cancer and other noncommunicable diseases, the major causes of death in most countries.