Immune-Based Interventions Against Infectious Diseases

描述（由申请人提供）：传染病仍然是世界范围内死亡和疾病的主要原因。我们应对新出现的传染病挑战的战略是建立传染病免疫学研究人员的临界质量，致力于合作和创新。该COBRE的总体目标是“基于免疫的传染病干预措施”，旨在推动全球重要传染病的多学科和跨机构研究计划的发展。COBRE的统一科学主题是病原体和宿主界面的转化研究。该COBRE代表了罗得岛大学普罗维登斯校区免疫学和信息学研究所（I Cubed）与罗得岛医院国际健康研究中心（CIHR）之间的合作伙伴关系。这两个小组都建立了NIH资助的传染病、免疫学和全球健康研究项目;他们在普罗维登斯的共同兴趣和密切联系为创建协同研究团队提供了理想的机会。COBRE的具体目标是： 1.建立一个综合研究社区，为罗得岛社区提供转化传染病免疫学研究的领导。 2.通过支持统计和数据管理、细胞分析和分选以及Luminex高通量分析的研究核心，为免疫学研究建立基础设施。 3.招募有前途的初级研究人员，并由NIH资助的研究人员提供指导。 4.支持由初级研究人员领导的转化传染病免疫学多学科研究计划。

DESCRIPTION (provided by applicant): Infectious diseases continue to represent major causes of death and disease worldwide. Our strategy to address the challenge of new and emerging infectious diseases is to build a critical mass of investigators in infectious diseases immunology, committed to collaboration and innovation. The overall objective of this COBRE, "Immune-Based Interventions against Infectious Diseases," is to advance the development of a multidisciplinary and trans-institutional research program in infectious diseases of global importance. The unifying scientific theme of the COBRE is translational research at the interface of the pathogen and host. This COBRE represents a partnership between the Institute for Immunology and Informatics (I Cubed) at the University of Rhode Island's Providence campus, and the Center for International Health Research (CIHR) at Rhode Island Hospital. Both groups have established NIH-funded research programs in infectious diseases, immunology, and global health; their shared interests and close proximity in Providence present an ideal opportunity to create a synergistic research team. The Specific Aims of this COBRE are: 1. Establish an integrated research community to provide leadership in translational infectious diseases immunology research to the Rhode Island community. 2. Build infrastructure for immunology research through support for Research Cores in Statistics and Data Management, Cell Analysis and Sorting, and Luminex High-Throughput Analysis. 3. Recruit promising junior investigators and provide mentoring by established NIH-funded researchers. 4. Support a multidisciplinary research program led by junior investigators in translational infectious diseases immunology.