2/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research

马萨诸塞大学波士顿分校和达纳-法伯/哈佛大学癌症 中心(DF/HCC)于2002年8月启动了他们的伙伴关系。伙伴关系的最初几年在 U56供资期间(2005-2010年)建立了所需的基础支持和科学领导 建立扎实、充满活力的研究协作。展望未来，U54机制利用了这一点 因此，在研究、能力建设和外联方面开展了一系列强有力的活动。两把钥匙 原则指导着波士顿大学和DF/HCC之间的这种持续的伙伴关系：a)共同和密切的 有兴趣解决癌症发病率中的种族、民族和社会经济差异问题， 发病率和死亡率；以及b)相信通过伙伴关系，每个机构都将受益 这是两个人都不能单独实现的。这份续期申请提供了广泛的证据，证明 这些原则的运作方式，为两个机构带来的好处，以及 这一伙伴关系现在准备在更高的水平上在科学上取得重大进展 癌症控制。我们正在提出利用最新科学来理解和解决问题的活动 通过体现我们伙伴关系主题的跨学科方法实现癌症差异 社会。为了支持我们新的凝聚力主题，我们提出了三个成熟、竞争激烈的 基础生物医学和人口科学的几个领域的研究项目将使用 汇聚和影响癌症和癌症健康差异的证据和方法 分析水平。为了阐明新的研究机会领域，伙伴关系很高兴探索 以生物学为基础的科学和社会/行为科学的交集。当务之急 摘要： “ 合作伙伴关系的主要内容是：1)继续在马萨诸塞州大学进行生物医学和癌症研究的能力建设 波士顿和DF/HCC癌症差异研究；2)加强和扩大以下方面的研究经验 学生特别关注代表不足的少数族裔(URM)，在整个教育领域 管道-从本科生到博士后水平(见研究教育核心)；3)继续关闭 指导早期调查人员，重点是研究和职业发展；4)建立 强大和强大的外联核心，利用科学的状态从传播和 执行科学(D&I)，用于建立伙伴关系、转化知识和监测成果 关于在社区组织中建立和维持能力的翻译工作(见 外展核心)；5)通过两个服务核心向U54调查人员提供基础设施支持； 包括研究设计和分析以及基因组学核心(见共享资源核心)；以及6) 通过专门的规划和研究教育方案确保项目、核心和研究教育方案的可持续性 执行与国立卫生研究院--机制、基金会支持和/或机构支持相匹配的赠款。

The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) initiated their Partnership in August 2002. The early years of the Partnership during the U56 funding period (2005-2010) established the foundational support and scientific leadership needed to build a solid and vibrant research collaboration. Moving forward, the U54 mechanism drew on this foundation resulting in a robust set of activities in research, capacity building and outreach. Two key tenets guide this sustained partnership between UMass Boston and DF/HCC: a) A common and intense interest in addressing the problem of racial, ethnic, and socioeconomic disparities in cancer incidence, morbidity, and mortality; and b) A belief that through the Partnership, each institution will achieve benefits that neither could achieve on its own. This application for renewal provides extensive evidence of the ways these tenets have been operationalized, the resulting benefits for both institutions and the ways in which this Partnership is now poised to make, at an elevated level, significant advances to the science of cancer control. We are proposing activities that draw on the latest science to understand and address cancer disparities through a transdisciplinary approach that embodies our Partnership theme of “Cells to Society. In support of our new cohesive theme, we have proposed three sophisticated, highly competitive research projects across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. To elucidate new areas of research opportunity, the Partnership is excited to explore the intersection between biology-based sciences and social/behavioral sciences. The immediate priorities Summary: ” of the Partnership are: 1) Continuing capacity building for biomedical and cancer research at UMass Boston and cancer disparities research at DF/HCC; 2) Enhancing and scaling up research experiences for students with a specific focus on underrepresented minorities (URMs), across the entire educational pipeline –from undergraduate to postdoctoral levels (see Research Education Core); 3) Continuing close mentoring of early stage investigators with a focus on research and career development; 4) Building a strong and robust Outreach Core that draws on the state of the science from dissemination and implementation sciences (D&I) for building partnerships, translating knowledge and monitoring the results of the translation efforts to build and sustain capacity among community-based organizations (see Outreach Core); 5) Offering infrastructural support to U54 investigators through two service cores, including the Research Design and Analysis, and Genomics Cores (see Shared Resource Core); and 6) Ensuring sustainability for projects, Cores and research education programs via dedicated planning and execution of grant matching with NIH-mechanisms, foundation support and/or institutional support.