Enhanced Surveillance for Newly preventable Diseases (ARI and AGE Surveillance) Rochester, NY

摘要 这项提议是为了加强纽约州罗切斯特的新疫苗监测网络(NVSN)站点，该站点 10年来一直专注于对急性胃肠炎(AGE)的前瞻性、基于人群的监测 由轮状病毒、诺沃克病毒和其他病毒病原体引起，在过去的一年里，以人群为基础 监测急性呼吸道感染。我们建议继续并扩大对ARI的监测， 重点关注流感、呼吸道合胞病毒(RSV)、肠道病毒D68(EV-D68)和其他疫苗- 可预防的或潜在的疫苗可预防的病毒，以便既测量流感疫苗 预防住院儿童中经实验室确认的流感感染的有效性 并评估与ARIS有关的病毒病原体的住院负担，特别是 流感、RSV和EV-D68。我们还将继续年龄监测，以允许类似的确定 住院或就诊儿童的年龄负担和轮状病毒疫苗效果 各部门。 NVSN的总体目标是让全国了解可预防疫苗的负担 疾病以及新疫苗和疫苗政策的影响。我们的罗切斯特NVSN站点(一个创始 NVSN成员)，在塑造NVSN的所有方面，包括以人口为基础方面一直处于领先地位 监测新的或即将到来的疫苗，疫苗有效性(VE)研究，诊断的改进 实验室方法、卫生服务和流行病学研究以及研究结果的传播。我们有 基础设施和综合专业知识，以便在供资期间的第一天开始所有活动。 我们的NVSN网站有：有经验的人员领导和发表了许多过去的NVSN流感VE， 监测和分子诊断实验室研究；准确的实验室和监测技术 符合疾病预防控制中心的程序；以及出色的流行病学和卫生服务研究能力。 我们可全面查阅所有医院及急症室的资料库，以配合监察活动。我们的集水区 地区，门罗县，纽约州/罗切斯特市统计区域，总人口100万； 门罗县95%的18岁居民儿童的ARI入学是在我们的两个NVSN 医院，每年有近1 000人因ARIS住院。因此，我们就有了“被俘人口”。 非常适合NVSN基于人群的监测项目。这项提案将提供关键的 提供信息，以制定与预防儿童VPD的国家目标相一致的健全政策。

ABSTRACT This proposal is to enhance the New Vaccine Surveillance Network (NVSN) site in Rochester, NY, which has for 10 years been focused on prospective, population-based surveillance for acute gastroenteritis (AGE) caused by rotavirus, norovirus, and other viral pathogens, and for the past year, population-based surveillance for acute respiratory infections. We propose to continue and extend surveillance for ARI with a focus on influenza, respiratory syncytial virus (RSV), enterovirus-D68 (EV-D68), and other vaccine- preventable or potentially vaccine-preventable viruses, in order to both measure influenza vaccine effectiveness (VE) in preventing laboratory-confirmed influenza infections among hospitalized children <18 years of age, and to assess the inpatient burden of viral pathogens associated with ARIs, particularly influenza, RSV and EV-D68. We also will continue the AGE surveillance to allow for similar determinations of AGE burden and rotavirus vaccine efficacy among children hospitalized or visiting the emergency departments. The over-arching goal of the NVSN is to inform the nation about the burden of vaccine-preventable diseases (VPDs), and the impact of new vaccines and vaccine policies. Our Rochester NVSN site (a founding NVSN member), has been a leader in shaping all aspects of the NVSN, including population-based surveillance for new or upcoming vaccines, vaccine effectiveness (VE) studies, refinement of diagnostic laboratory methods, health services and epidemiologic studies, and dissemination of findings. We have the infrastructure and comprehensive expertise to begin all activities on day 1 of the funding period. Our NVSN site has: experienced personnel who have led and published many past NVSN influenza VE, surveillance, and molecular diagnostic laboratory studies; accurate laboratory and surveillance techniques consistent with CDC procedures; and outstanding epidemiologic and health services research capabilities. We have full access to all hospital and ED databases to complement surveillance activities. Our catchment area, the Monroe County NY/Rochester Metropolitan Statistical Area, has a total population of >1,000,000; >95% of ARI admissions for Monroe County resident children <18 years of age occur at our two NVSN hospitals, with nearly 1,000 hospitalizations for ARIs per year. Thus, we have a “captured population” precisely suited for the NVSN population-based surveillance projects. This proposal will provide critical information to develop sound polices consistent with national goals to preventing VPD in children.