IP21-002, Enhanced Surveillance Network for Enteric and Respiratory Viruses in Children: Assessing Disease Burden, Natural History, and Vaccine Effectiveness

IP21-002，儿童肠道和呼吸道病毒的增强监测网络：评估疾病负担、自然史和疫苗有效性

• 批准号: 10340747
• 负责人: Geoffrey Alan Weinberg
• 金额: $ 144.16万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10340747
• 关键词: IP21; 002; Enhanced; Surveillance; Network

PROJECT SUMMARY/ABSTRACT (COMPONENTS A, B and C): Viral acute respiratory infections (ARI) and acute gastroenteritis (AGE) remain major causes of morbidity in children, making vaccine development and implementation a high public health priority. The overall goal of the CDC New Vaccine Surveillance Network (NVSN) is to establish a network of US institutions that develop and implement standard research protocols to answer important questions about the burden of disease and natural history of vaccine preventable diseases, specifically, those causing ARI and AGE. A second goal of population-based NVSN surveillance is to provide accurate estimates of vaccine effectiveness (VE) in preventing pediatric hospitalization or medical care visits. A third goal is the ability to rapidly pivot to study novel agents such as enterovirus-D68 (EV-D68) or SARS-CoV-2, and syndromes such as acute flaccid myelitis (AFM) and multisystem inflammatory syndrome in children (MIS-C). The proposed work (comprising Mandatory Core A, and Optional Components B and C) will enhance the NVSN site in Rochester, NY—one of 2 original members of the now 7-site network. For 20 years we have published important studies on the burden of disease and natural history of AGE due to rotavirus and norovirus, and ARI due to influenza, (RSV), and other viruses. These data helped inform AAP and ACIP on pediatric influenza and rotavirus vaccination, and palivizumab use for RSV prevention. Our specific aims are:  Mandatory Core Component A: Perform prospective, population-based active surveillance for ARIs and AGEs in inpatient and ED settings as well as asymptomatic controls, for children 0-18 years. We will use molecular diagnostics for rotavirus, norovirus, influenza, RSV, PIV, EV-D68, SARS-CoV-2, and other viruses. We will assess VE for influenza, rotavirus, and future SARS-CoV-2 vaccines in preventing pediatric hospitalizations and ED visits. We will delineate the disease burden of ARI and AGE using our unique capture of virtually all pediatric hospitalizations and ED visits in our region. We will assess the impact of future vaccines and other immunoprophylaxis strategies. We will perform active surveillance and epidemiologic studies of acute flaccid myelitis (AFM) syndrome in children. Finally, we will perform and lead epidemiological, implementation and laboratory studies based on population-based NVSN surveillance.  Optional Component B: Implement active prospective population-based ARI/AGE surveillance studies in children seeking medical care in outpatient practices, as the burden of ARI and AGE are likely high.  Optional Component C: Investigate the incidence, spectrum of disease, and risk factors associated with SARS-CoV-2 MIS-C. Our proposed research will provide high impact information to develop sound policies for the prevention of pediatric vaccine-preventable diseases, and to improve the health of US children.

项目总结/摘要（组件A、B和C）： 病毒性急性呼吸道感染和急性肠胃炎仍然是发病的主要原因 在儿童中，使疫苗的开发和实施成为高度优先的公共卫生事项。的总目标 疾病预防控制中心新疫苗监测网络（NVSN）将建立一个美国机构网络， 并实施标准的研究方案，以回答有关疾病负担的重要问题， 疫苗可预防疾病的自然史，特别是那些引起ARI和AGE的疾病。第二个目标是 基于人群的NVSN监测是为了提供疫苗有效性（VE）的准确估计， 防止儿科住院或就医。第三个目标是快速转向学习的能力 新型病原体如肠道病毒-D 68（EV-D 68）或SARS-CoV-2，以及急性弛缓性麻痹等综合征， 儿童多系统炎性综合征（MIS-C）。 拟议工作（包括强制性核心A和可选组件B和C）将加强 位于纽约州罗切斯特的NVSN站点-现在的7站点网络的2个原始成员之一。20年来， 发表了关于轮状病毒引起的疾病负担和AGE自然史的重要研究， 诺如病毒和流感引起的ARI（RSV）和其它病毒。这些数据有助于AAP和ACIP了解 儿科流感和轮状病毒疫苗接种，以及帕利珠单抗用于RSV预防。我们的具体目标是： * 强制性核心组成部分A：对阿里斯进行前瞻性、基于人群的主动监测， 0-18岁儿童在住院和艾德环境以及无症状对照中的AGEs。我们将使用 轮状病毒、诺如病毒、流感病毒、RSV、PIV、EV-D 68、SARS-CoV-2和其他病毒的分子诊断。 我们将评估流感、轮状病毒和未来SARS-CoV-2疫苗在预防儿童 住院和艾德就诊。我们将描述ARI和AGE的疾病负担， 捕获我们地区几乎所有的儿科住院和艾德就诊。我们将评估 未来的疫苗和其他免疫预防策略。我们将进行积极的监视， 儿童急性弛缓性肌麻痹综合征的流行病学研究最后，我们将执行和领导 流行病学，实施和实验室研究的基础上，以人口为基础的NVSN监测。 * 可选部分B：实施积极的前瞻性基于人群的ARI/AGE监测研究， 儿童在门诊寻求医疗服务，因为ARI和AGE的负担可能很高。 可选成分C：调查与糖尿病相关的发病率、疾病谱和风险因素。 SARS-CoV-2 MIS-C。 我们建议的研究将提供高影响力的信息，以制定健全的预防政策。 儿童疫苗可预防的疾病，并改善美国儿童的健康。