Enhanced Surveillance for Newly preventable Diseases (ARI and AGE Surveillance) Rochester, NY

加强对新可预防疾病的监测（ARI 和 AGE 监测）纽约州罗彻斯特

• 批准号: 9333097
• 负责人: Geoffrey Alan Weinberg
• 金额: $ 100万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9333097
• 关键词: Enhanced; Surveillance; Newly; preventable; Diseases

ABSTRACT This proposal is to enhance the New Vaccine Surveillance Network (NVSN) site in Rochester, NY, which has for 10 years been focused on prospective, population-based surveillance for acute gastroenteritis (AGE) caused by rotavirus, norovirus, and other viral pathogens, and for the past year, population-based surveillance for acute respiratory infections. We propose to continue and extend surveillance for ARI with a focus on influenza, respiratory syncytial virus (RSV), enterovirus-D68 (EV-D68), and other vaccine- preventable or potentially vaccine-preventable viruses, in order to both measure influenza vaccine effectiveness (VE) in preventing laboratory-confirmed influenza infections among hospitalized children <18 years of age, and to assess the inpatient burden of viral pathogens associated with ARIs, particularly influenza, RSV and EV-D68. We also will continue the AGE surveillance to allow for similar determinations of AGE burden and rotavirus vaccine efficacy among children hospitalized or visiting the emergency departments. The over-arching goal of the NVSN is to inform the nation about the burden of vaccine-preventable diseases (VPDs), and the impact of new vaccines and vaccine policies. Our Rochester NVSN site (a founding NVSN member), has been a leader in shaping all aspects of the NVSN, including population-based surveillance for new or upcoming vaccines, vaccine effectiveness (VE) studies, refinement of diagnostic laboratory methods, health services and epidemiologic studies, and dissemination of findings. We have the infrastructure and comprehensive expertise to begin all activities on day 1 of the funding period. Our NVSN site has: experienced personnel who have led and published many past NVSN influenza VE, surveillance, and molecular diagnostic laboratory studies; accurate laboratory and surveillance techniques consistent with CDC procedures; and outstanding epidemiologic and health services research capabilities. We have full access to all hospital and ED databases to complement surveillance activities. Our catchment area, the Monroe County NY/Rochester Metropolitan Statistical Area, has a total population of >1,000,000; >95% of ARI admissions for Monroe County resident children <18 years of age occur at our two NVSN hospitals, with nearly 1,000 hospitalizations for ARIs per year. Thus, we have a “captured population” precisely suited for the NVSN population-based surveillance projects. This proposal will provide critical information to develop sound polices consistent with national goals to preventing VPD in children.

摘要 该提案旨在加强纽约州罗切斯特的新疫苗监测网络（NVSN）站点， 10年来一直专注于急性胃肠炎（AGE）的前瞻性、基于人群的监测 由轮状病毒，诺如病毒和其他病毒病原体引起，在过去的一年里， 监测急性呼吸道感染。我们建议继续和扩大对急性呼吸道感染的监察， 专注于流感、呼吸道合胞病毒（RSV）、肠道病毒-D 68（EV-D 68）等疫苗- 可预防或潜在的疫苗可预防的病毒，以衡量流感疫苗 在<18岁住院儿童中预防实验室确诊流感感染的有效性（VE） 年龄，并评估与阿里斯相关的病毒病原体的住院负担，特别是 流感、RSV和EV-D 68。我们还将继续进行年龄监测，以便对 住院或急诊就诊儿童的年龄负担和轮状病毒疫苗有效性 部门 NVSN的首要目标是让全国了解疫苗可预防疾病的负担。 疾病（VPD），以及新疫苗和疫苗政策的影响。我们的罗切斯特NVSN站点（一个创建 NVSN成员），一直是塑造NVSN各个方面的领导者，包括基于人口的 监测新的或即将到来的疫苗，疫苗有效性（VE）研究，改进诊断 实验室方法、卫生服务和流行病学研究以及研究结果的传播。我们有 基础设施和全面的专门知识，以便在供资期的第一天开始开展所有活动。 我们的NVSN网站有：经验丰富的人员谁领导和出版了许多过去的NVSN流感VE， 监测和分子诊断实验室研究;准确的实验室和监测技术 符合CDC程序;和杰出的流行病学和卫生服务研究能力。 我们可以完全访问所有医院和艾德数据库，以补充监测活动。我们的集水区 门罗县纽约/罗切斯特大都会统计区，总人口> 1，000，000; 门罗县18岁以下居民儿童的ARI入院率>95%发生在我们的两个NVSN 医院，每年有近1,000人因阿里斯住院。因此，我们有一个“被捕获的人口” 非常适合NVSN基于人口的监测项目。该提案将提供关键的 信息，以制定健全的政策符合国家目标，以防止儿童VPD。