权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Bladder Blood Flow and Vascular Contractility Regulate Bladder Function

膀胱血流量和血管收缩力调节膀胱功能

基本信息

批准号：
9130890
负责人：
Nathan Roger Tykocki
金额：
$ 14.9万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9130890
关键词：
Acetylcholine Affect Aging Biology Bladder Bladder Dysfunction Blood Vessels Blood flow Caliber Clinical Conscious Corrosion Casting Data Development Diabetes Mellitus Diabetic mouse Doctor of Philosophy Electrophysiology (science)Endothelin-1 Environment Frequencies Functional disorder Goals Health Hypertension Hypoxia Impaired health In Vitro Institution Kir2.1 channel Knock-out Laboratory Research Link Lower urinary tract Measurement Mediating Membrane Potentials Mentors Mentorship Methods Michigan Microscopy Neurokinin A Neurologic Nitric Oxide Obesity Oryctolagus cuniculus Pathology Patients Perfusion Pharmaceutical Preparations Pharmacology Pharmacology and Toxicology Physiology Postdoctoral Fellow Potassium Channel Preparation Program Development Property Quality of life Regulation Reporting Research Research Personnel Research Project Grants Role Sensory Signal Transduction Smooth Muscle Smooth Muscle Myocytes Stream Symptoms Techniques Therapeutic Therapeutic Intervention Tissues Training Training Programs Transitional Epithelium Translational Research Universities Urge Incontinence Urinary Tract Physiology Urination Urodynamics Urologist Urothelium Vascular Smooth Muscle Vasoconstrictor Agents Vasodilator Agents Vermont afferent nerve arteriole career constriction diabetic diabetic patient experience graduate student health related quality of life in vivo lower urinary tract symptoms novel pressure response skills social stigma symptom treatment traditional therapy urinary

项目摘要

DESCRIPTION (provided by applicant): This proposal describes a 5-year program for the development of an academic career in lower urinary tract physiology. The Candidate has a background in smooth muscle physiology, and completed doctoral training in Pharmacology and Toxicology under the mentorship of Drs. Stephanie Watts and William Jackson (Michigan State University). He then came to the University of Vermont as a Postdoctoral Fellow to begin a path toward an independent research career. He now combines his strengths in smooth muscle physiology and vascular pharmacology to create a novel proposal investigating bladder blood flow as it relates to bladder dysfunction in diabetes. Nearly half of all diabetic patients experience lower urinary tract symptoms (LUTS), which significantly reduce their quality of life. Although ample evidence links impaired bladder blood flow to LUTS, a fundamental gap exists in our understanding of bladder blood flow regulation and its effects on bladder function. The goals of this project are to understand how the unique properties of the urinary bladder vasculature regulate bladder function. Furthermore, this project will investigate if decreased blood flow leads to bladder dysfunction in diabetes, with a specific focus on signaling mechanisms that regulate vessel tone in bladder arterioles. This hypothesis-driven research project will allow the applicant to develop skills in state-of- the art in vitro and in vivo physioogy methods, including electrophysiology, diameter and membrane potential measurements in isolated blood vessels, and in vivo urodynamic measurements, that will provide unprecedented detail into vascular function in the urinary bladder during diabetes. The results could potentially re-frame LUTS treatment to include both vascular and neurological therapeutic interventions. The University of Vermont (UVM) is internationally recognized for its strength in smooth muscle biology, with unique expertise in both vascular and urinary bladder physiology. Mark Nelson, Ph.D. will mentor the Candidate's scientific development. Dr. Nelson is a recognized leader in the field of vascular biology and bladder physiology and has trained numerous postdoctoral fellows and graduate students, many of whom are now established independent investigators. To enhance the Candidate's training, the program enlists the expertise of a mentoring committee, including Drs. Joseph Brayden, George Wellman, Margaret Vizzard and Mark Plante. Dr. Brayden pioneered techniques for the study of vascular smooth muscle membrane potential. Dr. Wellman adds expertise in K+ channel function and electrophysiology. Dr. Vizzard brings substantial experience with bladder research and in vivo conscious cystometry. Dr. Plante is a successful clinical urologist with perspectives on translational science and research. This research environment maximizes the potential for the Candidate to establish a scientific niche from which an academic career can be constructed. This project will facilitate continued technical, intellectual, and professional training of the Candidate, and will assist the Candidate in the establishment of an independent research laboratory at an academic research institution.