Synthesis Core

合成核心

• 批准号: 9149262
• 负责人: HANS-JOACHIM LEHMLER
• 金额: $ 16.84万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-12 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9149262
• 关键词: Acetylcysteine; Address; Adult; Air; Animals; Area; Body Burden; Catechols; Chicago; Child; Development; Diazomethane; Exposure to; Funding; Glucuronides; Glutathione; Goals; Hydroquinones; In Vitro; Individual; Inhalation Exposure; Inorganic Sulfates; Iowa; Laboratory Study; Mammals; Metabolic; Parents; Peer Review; Plants; Polychlorinated Biphenyls; Positioning Attribute; Preparation; Program Research Project Grants; Publications; Quinones; Rattus; Reagent; Research; Research Personnel; Research Project Grants; Research Support; Resources; Schools; Series; Site; Source; Superfund; Testing; Time; Tissues; Toxic effect; Universities; Unspecified or Sulfate Ion Sulfates; Volatilization; community based participatory research; experience; exposed human population; field study; in vivo; innovation; novel; programs; repository; response

PROJECT SUMMARY The Superfund Research Program at the University of Iowa (isrp) investigates the consequences of atmospheric sources and exposures to semi-volatile, lower-chlorinated polychlorinated biphenyls (PCBs). The biomedical and environmental research projects of the isrp need a variety of study compounds ranging from technical and synthetic PCB mixtures to pure PCB congeners and their metabolites for studies of the volatilization, transport and exposure of these PCB congeners. A major obstacle for these studies is the large number of 209 PCB congeners plus the large number of 837 possible hydroxylated (OH-PCBs), sulfated (PCB sulfates), glucuronidated (PCB glucuronides) and other PCB metabolites. Many of these PCB derivatives are not available from commercial sources or have never been synthesized before. Moreover, obtaining PCB mixtures or individual PCB congeners from commercial sources can be expensive, especially if large quantities are needed for animal studies. Therefore, the MAJOR OBJECTIVE of the Synthesis Core is to provide a large variety of fully characterized and highly pure PCB derivatives to individual research projects and research support cores within the isrp. If time and resources allow, the Synthesis Core will also make study compound available to other researchers, especially researchers from other Superfund Research Programs. At the same time, the Synthesis Core will continue to develop novel synthetic strategies for the synthesis of PCB congeners and PCB metabolites as needed by isrp researchers. The Specific Aims of the Synthesis Core are to 1) maintain and prepare PCB mixtures and pure PCB congeners; 2) prepare hydroxylated PCB derivatives; synthesize PCB sulfate metabolites; and 4) prepare miscellaneous compounds, including OH-PCB glucuronides and diazomethane. Synthesis Core researchers have extensive experience with the preparation, purification and characterization of all compounds requested by isrp research projects. The timely availability of PCB mixtures, individual OH-PCBs, PCB sulfates and other PCB metabolites will greatly enhance and, if the respective PCB metabolites are unavailable, enable the innovative studies proposed by isrp research projects.

项目摘要 爱荷华州大学的超级基金研究项目（isrp）调查了 大气来源和接触半挥发性、低氯多氯联苯。的 ISRP的生物医学和环境研究项目需要多种研究化合物， 将工业和合成多氯联苯混合物与纯多氯联苯同系物及其代谢物进行比较， 这些多氯联苯同系物的挥发、迁移和接触。这些研究的一个主要障碍是 209种多氯联苯同系物，加上大量的837种可能的羟基化（OH-PCB）、硫酸化（PCB 硫酸盐）、葡萄糖醛酸化（PCB葡萄糖醛酸）和其他PCB代谢物。这些PCB衍生物中有许多是 不能从商业来源获得或以前从未合成过。此外，获得PCB 来自商业来源的多氯联苯同系物的混合物或单个多氯联苯同系物可能很昂贵，特别是如果 动物研究所需的量。因此，综合核心的主要目标是 为个别研究项目提供种类繁多、特征充分的高纯度PCB衍生物 和研究支助核心。如果时间和资源允许，综合核心还将使 研究化合物提供给其他研究人员，特别是来自其他超级基金研究的研究人员 程序.与此同时，合成核心将继续开发新的合成策略， 根据isrp研究人员的需要，合成多氯联苯同系物和多氯联苯代谢物。的具体目标 核心是：1）保持和制备多氯联苯混合物和纯多氯联苯同系物; 2）制备 羟基化PCB衍生物;合成PCB硫酸盐代谢物; 4）制备杂合物， 包括OH-PCB葡糖苷酸和重氮甲烷。综合核心研究人员拥有丰富的经验 与isrp研究项目要求的所有化合物的制备，纯化和表征。 及时提供多氯联苯混合物、单个羟基多氯联苯、多氯联苯硫酸盐和其他多氯联苯代谢物， 大大提高，如果相应的PCB代谢物不可用，使创新的研究 由isrp研究项目提出。