Physiologically Derived DPOAE Measurement Methods

生理学衍生的 DPOAE 测量方法

• 批准号: 9468194
• 负责人: Samantha Marie Stiepan
• 金额: $ 6.98万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9468194
• 关键词: Address; Adult; Age; Anatomy; Auditory; Auditory system; Behavioral; Calibration; Characteristics; Clinical; Cochlea; Cognitive; Detection; Development; Diagnosis; Diagnostic; Ear; Early Diagnosis; Early Intervention; External auditory canal; Frequencies; Functional disorder; Generations; Health; Healthcare; Hearing; Hearing Aids; Impairment; Individual; Investigation; Lead; Learning; Length; Literature; Measurable; Measurement; Measures; Mental Health; Methods; Molecular; Newborn Infant; Outer Hair Cells; Output; Participant; Patient Self-Report; Persons; Physiological; Positioning Attribute; Production; Property; Protocols documentation; Site; Specificity; Stimulus; System; Techniques; Testing; Travel; United States; Variant; age related; base; clinical application; gene therapy; hearing impairment; hearing screening; improved; mechanical properties; novel; otoacoustic emission; performance tests; pressure; screening; social; stem cell therapy; tool

PROJECT SUMMARY/ABSTRACT For early diagnosis to lead to early intervention, our diagnostic tools need to provide affordable, accessible, and accurate tests of auditory function in any healthcare setting. As it is, distortion-product otoacoustic emission (DPOAE) testing provides an objective and noninvasive measure for evaluating the health of a common site of age-related declines in the auditory system – the outer hair cells. DPOAEs are a familiar tool due to their widespread use in newborn hearing screening and other audiological clinical applications. We contend that the test performance of DPOAEs can be improved significantly by aligning the methods to evoke them with known, place-specific mechanical properties of the mammalian cochlea. Currently utilized DPOAE measurement protocols are not optimized to detect dysfunction across the entire cochlea, especially those common age-related conditions that first manifest at the very base. Recent advances in calibration techniques and measurement hardware allows for delivery and recording of accurate emission levels up to 20 kHz [14-15]. This proposal tackles the remaining important step by developing a DPOAE test protocol guided by local cochlear mechanical properties and evaluating its test performance. We will use state-of-the art techniques for calibrating the stimulus pressure [64-65] and correcting the DPOAE pressure [45] to compensate for individual variations in ear canal anatomy while concurrently delivering stimuli and recording DPOAEs. The stimulus frequency ratio and stimulus levels will be adjusted in a frequency- specific manner to maximize DPOAE generation and improve test performance for both screening for hearing loss and predicting hearing thresholds. We hypothesize that DPOAE stimulus parameters that are optimized for the cochlear place of stimulation will evoke emissions that accurately reflect cochlear health and therefore will be closely related to behavioral hearing thresholds. We plan to pursue the following aims: (1) Develop a novel DPOAE measurement protocol optimized to local cochlear mechanical properties, (2) Evaluate the novel DPOAE measurement protocol in detecting the presence of hearing loss, and (3) Apply the novel DPOAE measurement protocol for the prediction of hearing thresholds. Through detailed investigation of physiologically derived characteristics of DPOAEs in young, normal-hearing adults, we expect that DPOAE amplitudes will be significantly correlated with behavioral hearing thresholds in normal-hearing and hearing-impaired individuals. This proposal leverages the latest developments in calibration and measurement hardware to develop a DPOAE measurement system that is optimized for local cochlear properties. These optimizations are expected to improve DPOAE test performance significantly positioning the new test as an important, affordable, and accessible tool for early detection of age-related cochlear function. The clinical implications are significant as we propose to improve a well-accepted clinical tool that can easily be automated for widespread deployment.

项目总结/摘要 为了实现早期诊断和早期干预，我们的诊断工具需要提供负担得起的， 在任何医疗保健环境中进行可访问的准确的听觉功能测试。事实上，扭曲产物 耳声发射（DPOAE）测试提供了一种客观和非侵入性的措施，用于评估 健康的一个共同的网站的年龄相关的下降在听觉系统-外毛细胞。DPOAE是一种 由于其广泛用于新生儿听力筛查和其他听力学临床 应用.我们认为，DPOAEs的测试性能可以通过调整DPOAEs的参数来显著提高。 方法，以唤起他们与已知的，特定位置的机械特性的哺乳动物耳蜗。 目前使用的DPOAE测量方案未被优化以检测跨组织的功能障碍。 整个耳蜗，特别是那些常见的年龄相关的条件，首先表现在非常基础。最近 校准技术和测量硬件的进步允许提供和记录准确的 发射电平高达20 kHz [14-15]。这项建议通过制定一项 以耳蜗局部力学特性为指导的DPOAE测试方案及其测试性能评价。我们 我将使用最先进的技术来校准刺激压力[64-65]和校正DPOAE 压力[45]，以补偿耳道解剖结构中的个体差异，同时传递刺激 并记录DPOAE。刺激频率比和刺激水平将在频率- 最大化DPOAE生成并提高听力筛查和听力筛查的测试性能的特定方式 听力损失和预测听力阈值。我们假设，DPOAE刺激参数优化， 刺激的耳蜗位置将引起准确反映耳蜗健康的发射， 将与行为听阈密切相关。 本论文的主要工作如下：（1）开发一种新的DPOAE测量方案 （2）评价DPOAE测量方案对耳蜗局部力学特性的影响。 检测听力损失的存在，和（3）应用新的DPOAE测量协议， 听力阈值的预测通过详细研究的生理来源的特点， 在听力正常的年轻人中，我们预期DPOAE振幅将显著相关 与听力正常和听力受损个体的行为听力阈值进行比较。 该提案利用校准和测量硬件的最新发展， DPOAE测量系统，针对局部耳蜗特性进行了优化。这些优化是意料之中的 提高DPOAE测试性能，使新测试成为一种重要的、经济实惠的， 早期检测与年龄相关的耳蜗功能的工具。临床意义重大， 我们提出改进一种可以容易地自动化以广泛部署的被广泛接受的临床工具。