Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus Disease
埃博拉病毒病幸存者的临床后遗症和泌尿生殖系统病毒动态
基本信息
- 批准号:9311358
- 负责人:
- 金额:$ 66.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-03-06 至 2022-02-28
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAcuteAddressAfricaAgeAreaBloodCCL4 geneCaringCervicalCessation of lifeCharacteristicsClinicalClinical ManagementClinical ResearchCollaborationsCommunicable DiseasesComplexConvalescenceDataData CollectionData QualityDetectionDiseaseDisease OutbreaksEbola Hemorrhagic FeverEbola virusEnrollmentEnsureEpidemicEventFoundationsFrequenciesFrightFutureGastrointestinal tract structureGenderGenital systemGenitourinary systemGoalsHealthcareHealthcare SystemsImmuneImmune responseImmunityImmunologic MarkersImmunologyImpairmentIndividualInfectionInflammationInflammatoryKnowledgeLiberiaLiquid substanceMedical HistoryMusculoskeletalNatural HistoryNeurologicParticipantPathogenesisPathogenicityPathway interactionsPatternPhysical ExaminationPositioning AttributePrevalenceProceduresProcessPublic HealthQuality ControlRNARecoveryRecruitment ActivityRecurrenceReportingResearch InfrastructureResearch MethodologyResearch PersonnelResidual stateRiskRoleSamplingSeminal fluidSeverity of illnessSierra LeoneSignal TransductionSiteStandardizationSurvivorsSymptomsSyndromeTherapeuticTimeTissuesTrainingViralViral AntigensViremiaVirusVirus DiseasesVirus ReplicationWomanWorkWorld Health Organizationbaseclinical infrastructureco-infectioncohortimmune activationimprovedinflammatory markerinflammatory milieumenmicrobialmultidisciplinarypublic health emergencypublic health relevancereproductive tractsexsurvivorshipsymptomatologyvaginal fluidviral RNA
项目摘要
PROJECT SUMMARY
The Ebola epidemic that has devastated West Africa evolved within months from a regional
humanitarian crisis to a global public health emergency. Over 27,000 infections and more than 11,000
deaths were reported by the World Health Organization (WHO) – an underestimate that already
eclipses the numbers of infections and deaths in all previous Ebola outbreaks combined by orders of
magnitude. While this epidemic has ebbed, and may even be over, the clinical complications of Ebola
virus disease (EVD) endure for the majority of the thousands of survivors. Our work and that of others
indicate that musculoskeletal, neurologic, and ocular complications can persist even two years after
recovery from acute Ebola disease. Further, there is evidence that there can be sustained shedding of
at least viral RNA in semen and vaginal fluid of survivors, which could signal presence of infectious
virus and/or serve to stimulate immune responses that may produce certain post-Ebola symptoms. The
small size of previous outbreaks and the absence of adequate infrastructure to collect, process and
analyze samples in the field have limited our understanding of the natural history of Ebola survivorship.
The primary goal of this proposal is a better understanding of the clinical sequelae of EVD. Specifically:
In AIM I we will describe and categorize the clinical symptomatology of Ebola survivors and
investigate host- and disease-related factors for these conditions.
In AIM II we probe putative pathogenic mechanisms for post-Ebola conditions including sustained
immune activation, altered gut integrity, and persistence of viral antigens in the uro-genital
compartment.
We will conduct this work in the context of close and strong working relationships with health care
leaders and Ebola survivor representatives in West Africa, and a well-developed infrastructure for
clinical research we have established in Liberia and Sierra Leone where we have recruited, enrolled,
and longitudinally followed and sampled over 400 Ebola survivors. Establishment of these cohorts
allowed our team to determine the feasibility of our approach and develop, pilot, and refine the
procedures needed to sustain high-quality data collection. This work also allows us to build and support
capacity. Staff in both nations have been trained in research methodology and are being encouraged to
develop their own proposals. We have established a validated platform for Ebola RNA detection in
blood, semen, and vaginal fluid at a national reference lab in Liberia and have trained this site in quality
control. Collectively, the proposed work will provide a much-needed characterization of the
convalescence from Ebola and its potential mechanisms, as well as better characterize the patterns of
Ebola RNA detection in genital fluids. With 25 outbreaks over the past 40 years and a notable increase
in the frequency of EVD outbreaks, the question is not if another outbreak will occur but when. This
study will ensure that the world is better prepared for the next epidemic through the improved
understanding of the clinical complications of Ebola virus disease, and through the implementation of
clinical research platforms in areas that are likely to see a recurrence of EVD.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William Fischer其他文献
William Fischer的其他文献
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{{ truncateString('William Fischer', 18)}}的其他基金
The Protective and Pathologic Features of the EVD Survivor Immune System
埃博拉病毒病幸存者免疫系统的保护和病理特征
- 批准号:
10639583 - 财政年份:2023
- 资助金额:
$ 66.54万 - 项目类别:
Prevalence, Pathogenesis, and Persistence of Lassa Fever in West Africa
西非拉沙热的流行情况、发病机制和持续性
- 批准号:
10362526 - 财政年份:2018
- 资助金额:
$ 66.54万 - 项目类别:
Prevalence, Pathogenesis, and Persistence of Lassa Fever in West Africa
西非拉沙热的流行情况、发病机制和持续性
- 批准号:
10092912 - 财政年份:2018
- 资助金额:
$ 66.54万 - 项目类别:
Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus Disease
埃博拉病毒病幸存者的临床后遗症和泌尿生殖系统病毒动态
- 批准号:
9014070 - 财政年份:2016
- 资助金额:
$ 66.54万 - 项目类别:
The Effect of Aging on LAIV Replication in Human Nasal Epithelial Cells
衰老对人鼻上皮细胞 LAIV 复制的影响
- 批准号:
8556553 - 财政年份:2013
- 资助金额:
$ 66.54万 - 项目类别:
The Effect of Aging on LAIV Replication in Human Nasal Epithelial Cells
衰老对人鼻上皮细胞 LAIV 复制的影响
- 批准号:
8719907 - 财政年份:2013
- 资助金额:
$ 66.54万 - 项目类别:
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