Semantic Data Lake for Biomedical Research

用于生物医学研究的语义数据湖

• 批准号: 9443736
• 负责人: Mansur R. Kabuka
• 金额: $ 5万
• 依托单位: INFOTECH SOFT, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9443736
• 关键词: Accelerometer; Acute; Address; Adoption; Area; Big Data; Biomedical Computing; Biomedical Research; Catalogs; Chronic Myeloid Leukemia; Clinical; Clinical Trials; Collection; Colorectal Cancer; Communities; Complex; Computer software; Data; Data Analyses; Data Analytics; Data Collection; Data Discovery; Data Quality; Data Science; Data Set; Data Sources; Demographic Factors; Development; Electronic Health Record; Ensure; Environment; Environmental Risk Factor; Evaluation; Explosion; Generations; Genetic; Genetic Markers; High-Throughput Nucleotide Sequencing; Income; Individual; Informatics; Ingestion; Institution; Knowledge; Knowledge Extraction; Legal; Legal patent; Liquid substance; Machine Learning; Malignant Neoplasms; Methods; Modeling; Non-Small-Cell Lung Carcinoma; Online Systems; Ontology; Phase; Policies; Precision therapeutics; Procedures; Process; Production; Productivity; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Retrieval; Risk; Secure; Security; Semantics; Services; Source; Specific qualifier value; Structure; System; Technology; Testing; Vocabulary; Work; base; cancer therapy; clinical data warehouse; cluster computing; computer based Semantic Analysis; cost effective; data access; data exchange; data integration; data management; data modeling; data resource; design; disease heterogeneity; experience; genetic information; handheld mobile device; indexing; individualized medicine; melanoma; migration; natural language; new technology; next generation; novel; precision medicine; prototype; success; systems research; targeted treatment; technology development; time use; tool

Capitalizing on the transformative opportunities afforded by the extremely large and ever-growing volume, velocity, and variety of biomedical data being continuously produced is a major challenge. The development and increasingly widespread adoption of several new technologies, including next generation genetic sequencing, electronic health records and clinical trials systems, and research data warehouses means that we are in the midst of a veritable explosion in data production. This in turn results in the migration of the bottleneck in scientific productivity into data management and interpretation: tools are urgently needed to assist cancer researchers in the assembly, integration, transformation, and analysis of these Big Data sets. In this project, we propose to develop the Semantic Data Lake for Biomedical Research (SDL-BR) system, a cluster-computing software environment that enables rapid data ingestion, multifaceted data modeling, logical and semantic querying and data transformation, and intelligent resource discovery. SDL-BR is based on the idea of a data lake, a distributed store that does not make any assumptions about the structure of incoming data, and that delays modeling decisions until data is to be used. This project adds to the data lake paradigm methods for semantic data modeling, integration, and querying, and for resource discovery based on learned relationships between users and data resources.

利用超大型和不断增长的 不断产生的生物医学数据的数量、速度和种类是一个重大挑战。的 开发和越来越广泛地采用几种新技术，包括 一代基因测序、电子健康记录和临床试验系统以及研究数据 仓库意味着我们正处于数据生产的真正爆炸之中。这反过来 导致科学生产力的瓶颈转移到数据管理中， 解释：迫切需要工具来帮助癌症研究人员组装，整合， 转换和分析这些大数据集。在这个项目中，我们建议开发语义 Data Lake for Biomedical Research（SDL-BR）系统是一个集群计算软件环境， 支持快速的数据摄取、多方面的数据建模、逻辑和语义查询， 转换和智能资源发现。SDL-BR基于数据湖的概念， 分布式存储，不对传入数据的结构做出任何假设，并且 延迟建模决策，直到使用数据。这个项目增加了数据湖范例方法 用于语义数据建模、集成和查询，以及用于基于学习到的 用户和数据资源之间的关系。