权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Principles of olfactory reward processing in the human brain

人脑嗅觉奖励处理原理

基本信息

批准号：
9381746
负责人：
Thorsten Kahnt
金额：
$ 0.43万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9381746
关键词：
Adaptive Behaviors Address Alzheimer&apos s Disease Amygdaloid structure Anatomy Animal Behavior Animals Area Behavior Behavioral Brain Brain imaging Brain region Chocolate Choice Behavior Clinical Code Cognition Computer Simulation Consumption Corpus striatum structure Data Decision Making Desire for food Development Diffusion Event Food Food Preferences Frontotemporal Dementia Functional Magnetic Resonance Imaging Genus Vanilla Goals Human Image Analysis Imaging Techniques Lead Learning Maps Mate Selections Mediating Methods Neuraxis Neurodegenerative Disorders Odors Olfactory Pathways Organism Outcome Pathway interactions Patients Pattern Perception Positioning Attribute Process Property Psychophysics Research Research Proposals Rewards Role Satiation Sensory Series Smell Perception Symptoms Testing Time auditory stimulus base clinically relevant expectation experience experimental study hedonic insight neuroimaging neuromechanism neuropsychiatric disorder novel novel diagnostics novel therapeutics piriform cortex relating to nervous system reward processing spectrograph tractography visual stimulus

项目摘要

PROJECT SUMMARY A crucial function of the central nervous system is to bias behavior toward events and outcomes that hold relevance for survival. It is well recognized that odors have a strong effect on animal behavior, as they guide food search and selection, maternal bonding, and mate selection. Even though humans do not consider olfaction to be a dominant sense, humans are similarly swayed by the rewarding properties of smells. With recent developments in the pattern-based analysis of functional magnetic resonance imaging (fMRI) data, we are now in a position to explore the neural mechanisms of olfactory reward processing in humans. The objective of the current research proposal is to capitalize on these novel methods in order to understand the neural mechanisms of odor-guided behavior in humans. Specifically, we will use functional and structural brain imaging in combination with olfactory psychophysics to reveal the functional anatomy and coding mechanisms of olfactory reward processing. The proposed studies will examine predictive neural representations of food odor identity and reward value, and their importance for olfactory reward-based behavior and learning. Complementary studies will track the anatomical pathways between olfactory and limbic brain regions, and delineate the specific information that is transmitted via these connections. Together these experiments will open a new window into understanding olfactory reward processing in the human brain at the functional, mechanistic, and anatomical level, with implications for neuroscientific research on adaptive behavior in general. Moreover, the findings of this research can lead to a better understanding of the olfactory and behavioral deficits described in a variety of neurodegenerative disorders, including Alzheimer's disease and frontotemporal dementia, and may ultimately provide insights into the development of novel diagnostic and therapeutic clinical approaches.

项目总结