Life Science and Biomedical technology Research center at NSLS-II LSBR

NSLS-II LSBR生命科学与生物医学技术研究中心

• 批准号: 9307876
• 负责人: Sean McSweeney
• 金额: $ 335.62万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307876
• 关键词: Automation; Automobile Driving; Biocompatible Materials; Biological Sciences; Biomedical Technology; Boston; Caring; Communities; Crystallization; Crystallography; Data; Life; Medical; Membrane; Metals; Optics; Productivity; Research; Research Personnel; Roentgen Rays; Scientist; Solid; Source; Spectrum Analysis; Synchrotrons; Tissues; Washington; fluorescence imaging; operation; programs; public health relevance; structural biology; success

DESCRIPTION (provided by applicant): The project will develop a world-leading suite of experimental facilities for the life-science research community. With the focus on macromolecular crystallography (MX) and x-ray scattering, there will also be user programs in correlated MX and optical spectroscopy, and one in fluorescence imaging of metals in biological materials. The extraordinary brightness of NSLS-II will provide unprecedentedly small, bright, and well-collimated x-ray beams. To exploit these qualities, extra care will be exerted to provide the best quality crystal-diffraction and x-ray scattering data from the NSLS-II beams, and high levels of automation. Multiple experimental modes will be installed for x-ray scattering to investigate solutions, membranes, and tissues. We expect high success of the project, owed in part to the remarkable community of life-science researchers in the 400 mile-long corridor from Boston to Washington, all within driving distance of BNL, and to the solid record of productivity in structural biology having been provided this community during the lifetime of the NSLS.

描述（由申请人提供）：该项目将为生命科学研究界开发一套世界领先的实验设施。随着对大分子晶体学（MX）和X射线散射的关注，也将有相关MX和光谱学的用户程序，以及生物材料中金属的荧光成像。NSLS-II的非凡亮度将提供前所未有的小，明亮和良好准直的X射线束。为了利用这些品质，将格外小心，以提供来自NSLS-II光束的最佳质量的晶体衍射和X射线散射数据，以及高水平的自动化。将安装多个实验模式用于X射线散射，以研究溶液、膜和组织。我们期望该项目取得巨大成功，这部分归功于从波士顿到华盛顿的400英里长的走廊上的生命科学研究人员，所有这些都在BNL的车程范围内，以及在NSLS的生命周期中为这个社区提供了结构生物学生产力的可靠记录。