The Center for Biomolecular Structure at NSLS-II

NSLS-II 生物分子结构中心

• 批准号: 9805052
• 负责人: Sean McSweeney
• 金额: $ 360万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9805052
• 关键词: Advisory Committees; Automation; Biocompatible Materials; Biological; Biological Sciences; Communities; Complex; Computer software; Crystallization; Crystallography; Data; Diagnostic radiologic examination; Ecology; Education and Outreach; Ensure; Fluorescence; Funding; Image; International; Investigation; Laboratories; Light; Maintenance; Metals; Methods; Pattern; Peer Review; Performance; Phase; Procedures; Research; Research Personnel; Resolution; Resources; Roentgen Rays; Scanning; Science; Source; Structure; Synchrotrons; Techniques; Time; Tissue imaging; Training; Work; absorption; beamline; bioimaging; contrast imaging; experience; fluorescence imaging; frontier; imaging program; improved; interest; multidisciplinary; multimodality; operation; peer; structural biology; tool

Abstract - Overall Core Brookhaven National Laboratory has developed a world-leading suite of experimental facilities for the life- science research community. Much of it is organized in the Center for Biomolecular Structure (CBMS), which has a focus on macromolecular crystallography (MX) and x-ray scattering, with a user program of imaging in biological materials: fluorescence imaging of metals, and full-field absorption and phase-contrast imaging on all materials. We exploit the unprecedentedly small, bright, and well-collimated x-ray beams of National Synchrotron Light Source II (NSLS-II) with experimental stations that provide the best possible crystal- diffraction and x-ray scattering data with high levels of automation. Our responsibility to the users is to enable hypothesis-driven research by having sufficient throughput to support high-volume systematic studies, and with the capability, through our assembly of diverse beamlines, to support multi-disciplinary work for complex investigations.

摘要-总体核心 布鲁克海文国家实验室开发了一套世界领先的生命实验设施， 科学研究界。其中大部分是在生物分子结构中心（CBMS）组织的， 专注于大分子晶体学（MX）和X射线散射，具有成像的用户程序， 生物材料：金属的荧光成像，全视场吸收和相位衬度成像 材料.我们利用了前所未有的小，明亮，以及良好的准直X射线束的国家 同步加速器光源II（NSLS-II）的实验站，提供最好的晶体- 衍射和X射线散射数据，自动化程度高。我们对用户的责任是 假设驱动的研究，有足够的吞吐量，以支持大量的系统研究，并与 通过我们组装不同的光束线，支持复杂的多学科工作的能力 调查事务所