Administration Core

行政核心

• 批准号: 9805053
• 负责人: Sean McSweeney
• 金额: $ 46.9万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9805053
• 关键词: Advisory Committees; Back; Biohazardous Substance; Biological; Biological Sciences; Businesses; Communities; Critiques; Crystallography; Data Collection; Department of Energy; Development; Ecology; Education and Outreach; Ensure; Fluorescence Microscopy; Goals; Head; Health; High Pressure Liquid Chromatography; Image; Infrastructure; Internet; Light; Measures; Methods; Microscopy; Mission; Molecular; Monitor; National Institute of General Medical Sciences; Performance; Positioning Attribute; Procedures; Process; Reporting; Research; Research Personnel; Research Support; Resources; Roentgen Rays; Role; Safety; Scanning; Schedule; Science; Services; Site; Site Visit; Source; Structure; Synchrotrons; System; Technology; Training; United States National Institutes of Health; Work; base; beamline; bioimaging; biological research; contrast imaging; experimental study; innovation; instrument; instrumentation; meetings; microscopic imaging; multidisciplinary; operation; programs; success; tomography; tool; web site

Abstract – Administration Core The overall goal of the Center for Biomolecular Structure (CBMS) at National Synchrotron Light Source II (NSLS- II) is to provide access to a broad range of state-of-the-art synchrotron capabilities at the NSLS-II. The proposed synchrotron center will be supported by both the National Institute of General Medical Sciences/National Institutes of Health (NIGMS/NIH) and the Department of Energy Office of Biological and Environmental Research (DOE BER). The CBMS team will administer the Center to allow for safe, responsive use by the research community, we will monitor use and develop the capabilities as appropriate to need. We will provide review-based access, training, and technical assistance to assure success of research programs that use this remarkable set of synchrotron resources, thereby enabling scientific discovery on scales from the atomic to the environmental. To pursue our support mission, we plan to make the best use of NSLS-II capabilities by employing multiple mature synchrotron technologies. We will support macromolecular crystallography (MX) at our micro-focusing beamlines through on-site visits, automatic data collection processes, and remote beamline access. For X-ray scattering we will support, static and online HPLC-backed small-angle scattering (SAXS). In addition, we will continue to extend the impact of the scanning-beam method for SAXS tomography and to support the use of low- energy x-ray scattering studies. Our Bioimaging Core will support use of both x-ray-fluorescence microscopy and contrast-imaging full-field microscopy for bio-environmental and bio-medical researchers, and will continue to develop these tools, driven by the needs of the biological and environmental-science communities.

摘要-管理核心 国家同步辐射光源II(NSLS-2)生物分子结构中心的总体目标是 Ii)是在NSLS-II上提供广泛的最先进的同步加速器能力。建议数 同步加速器中心将由国家普通医学科学研究所/国家 美国国立卫生研究院(NIGMS/NIH)和能源部生物与环境办公室 研究(能源部BER)。 CBMS团队将管理该中心，以允许研究社区安全、响应地使用，我们将 根据需要监控、使用和开发相应的功能。我们将提供基于审查的访问、培训、 和技术援助，以确保使用这套非凡的同步加速器的研究计划的成功 资源，从而能够在从原子到环境的范围内进行科学发现。 为了执行我们的支持任务，我们计划通过使用多个NSLS-II能力来充分利用 成熟的同步加速器技术。我们将在我们的微聚焦中支持大分子结晶学(MX 通过现场访问、自动数据收集过程和远程光束线访问，实现了对光束线的访问。用于X光检查 散射我们将支持静态和在线高效液相支持的小角散射(SAXS)。此外，我们还将 继续扩大扫描束方法对SAXS层析成像的影响，并支持使用低 能量x射线散射研究。我们的生物成像核心将支持使用x射线荧光显微镜和 生物环境和生物医学研究人员的对比成像全场显微镜，并将继续 在生物和环境科学界需求的推动下，开发这些工具。