Administration Core

摘要-管理核心 国家同步加速器光源II（NSLS-）生物分子结构中心（CBMS）的总体目标 II）是提供在NSLS-II获得广泛的最先进的同步加速器能力。拟议 同步加速器中心将得到国家普通医学科学研究所/国家 卫生研究所（NIGMS/NIH）和能源部生物和环境办公室 研究（DOE BER）。 CBMS团队将管理该中心，以允许研究界安全，快速地使用，我们将 监控使用情况并根据需要开发适当的功能。我们将提供基于审查的访问，培训， 和技术援助，以确保成功的研究计划，使用这套显着的同步加速器 资源，从而使科学发现的规模从原子到环境。 为了完成我们的支持使命，我们计划通过使用多个 成熟的同步加速器技术。我们将在我们的微聚焦支持大分子晶体学（MX） 通过现场访问、自动数据收集过程和远程光束线访问，用于x射线 我们将支持静态和在线HPLC支持的小角散射（SAXS）。此外，我们将 继续扩大扫描光束法对SAXS层析成像的影响，并支持使用低 能量X射线散射研究。我们的生物成像核心将支持使用X射线荧光显微镜， 为生物环境和生物医学研究人员提供对比成像全视野显微镜，并将继续 根据生物和环境科学界的需要开发这些工具。

Abstract – Administration Core The overall goal of the Center for Biomolecular Structure (CBMS) at National Synchrotron Light Source II (NSLS- II) is to provide access to a broad range of state-of-the-art synchrotron capabilities at the NSLS-II. The proposed synchrotron center will be supported by both the National Institute of General Medical Sciences/National Institutes of Health (NIGMS/NIH) and the Department of Energy Office of Biological and Environmental Research (DOE BER). The CBMS team will administer the Center to allow for safe, responsive use by the research community, we will monitor use and develop the capabilities as appropriate to need. We will provide review-based access, training, and technical assistance to assure success of research programs that use this remarkable set of synchrotron resources, thereby enabling scientific discovery on scales from the atomic to the environmental. To pursue our support mission, we plan to make the best use of NSLS-II capabilities by employing multiple mature synchrotron technologies. We will support macromolecular crystallography (MX) at our micro-focusing beamlines through on-site visits, automatic data collection processes, and remote beamline access. For X-ray scattering we will support, static and online HPLC-backed small-angle scattering (SAXS). In addition, we will continue to extend the impact of the scanning-beam method for SAXS tomography and to support the use of low- energy x-ray scattering studies. Our Bioimaging Core will support use of both x-ray-fluorescence microscopy and contrast-imaging full-field microscopy for bio-environmental and bio-medical researchers, and will continue to develop these tools, driven by the needs of the biological and environmental-science communities.