稳定胰高血糖素治疗高胰岛素血症-猫眼课题宝

稳定胰高血糖素治疗高胰岛素血症

批准号：

9333693

负责人：

Steve Eisenberg

金额：

$13.11万

依托单位：

AMIDEBIO, LLC

依托单位国家：

美国

项目类别：

财政年份：

2017

资助国家：

美国

项目状态：

已结题

起止时间：

2017-09-18 至 2019-08-31

来源：

https://reporter.nih.gov/project-details/9333693

关键词：

Agitation Amino Acid Substitution Biological Assay Birth Blindness Caring Cerebral Palsy Cessation of life Chemicals Child Clinical Clinical Research Clinical Trials DNA Sequence Alteration Defect Diabetes Mellitus Diffuse Disease Effectiveness Epilepsy Failure Family Fluorescence Formulation Future Glucagon Glucagon Receptor Glucose Glucose Plasma Concentration Glutamine Goals High Pressure Liquid Chromatography Human Hyperinsulinism Hypoglycemia In Vitro Incidence Infusion procedures Kinetics Lead Learning Disabilities Legal patent Length of Stay Libraries Life Life Style Medical Monitor Mutation Newborn Infant Operative Surgical Procedures Outcome Pancreatectomy Patient-Focused Outcomes Patients Persistent Hyperinsulinemia Hypoglycemia of Infancy Phase Process Production Property Pump Regulation Resistance Series Side Sterility System Technology Testing Thermodynamics Tube United States amino group analog base chemical stability cost deamidation design effective therapy improved in vivo insulin secretion large scale production milligram mouse model phase 2 study prevent stability testing subcutaneous

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英文摘要

SUMMARY/ABSTRACT A series of glucagon analogues will be designed, produced at milligram levels, tested for solution stability and both in vitro and in vivo activity with the goal of providing a long term treatment for hyperinsulinism.

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海外基金

Stable Glucagon for Treatment of Hyperinsulinism

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