Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular Carcinoma
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular Carcinoma
批准号:
9677541
负责人:
MATAM VIJAY-KUMAR
金额:
$28.09万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-01 至 2022-06-30
中文摘要
项目摘要
我们研究的总体目标是确定机制和因子/代谢物
可溶性纤维菊糖诱发小鼠肝细胞癌
缺乏Toll样受体5(TLR 5)。TLR 5是一种先天免疫受体,
细菌鞭毛蛋白在肠道微生物群稳态中起关键作用。TLR5
缺陷小鼠表现出代谢综合征的特征,
依赖。这项工作的目的是阐明如何一种天然的饮食成分,
使用的食品添加剂在先天性免疫缺陷小鼠中驱动HCC,
微生物过度生长提出了三个具体目标,每个目标都调查
肝细胞癌在肠道生态失调的小鼠中发展的机制。这三个目标是
相互关联、独立可实现,并解决以下方面的贡献:(i)结构
不同的天然可溶性纤维,(ii)肠道微生物群,和(iii)宿主肝脏
脂肪生成/脂肪分解对HCC的发展的影响。
这项建议对公共卫生有潜在的影响,
菊粉在食品工业中的过度使用。我们的工作将阐明
菊粉和/或SCFA的潜在有害作用。此外,人类HCC是第六个
是全球最常见的癌症和第三大癌症相关死亡原因。越高
HCC患者的死亡率是由于诊断不佳和晚期,
其异质性和无症状性。这证明了一种新的肝癌原
独立模型,以更好地了解人类HCC。该提案旨在实现这一目标。
约束。
英文摘要
Project Summary
The overall goal of our research is to identify the mechanisms and factors/metabolite(s)
by which dietary soluble fiber inulin induces hepatocellular carcinoma (HCC) in mice
lacking toll-like receptor 5 (TLR5). TLR5, an innate immune receptor that senses
bacterial flagellin, plays a critical role in gut microbiota homeostasis. Accordingly, TLR5
deficient mice display hallmarks of metabolic syndrome, which is absolutely microbiota
dependent. This work aims to elucidate how a natural dietary component and widely
used food additive drives HCC in innate immune deficient mice coupled with gut
microbiotal overgrowth. Three specific aims are proposed, each of which investigates
the mechanisms by which HCC develops in mice with gut dysbiosis. The three aims are
interrelated, independently achievable and address the contributions of (i) structurally
different natural soluble fibers, (ii) gut microbiota, and (iii) host hepatic
lipogenesis/lipolysis to the development of HCC.
This proposal has potential implications for public health, given the prevalent and
overuse of inulin in the food industry. Our work would elucidate the underappreciated
potential detrimental effects of inulin and/or SCFAs. Further, human HCC is the sixth
most common cancer and third most cause of cancer related deaths globally. The higher
mortality rates in patients with HCC are due to poor and late stage diagnosis because of
its heterogeneous and asymptomatic nature. This warrants a novel, hepatocarcinogen
independent model to better understand human HCC. This proposal seeks to fulfill this
constraint.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Role of neutrophil extracellular traps (NETs) in Inflammatory bowel disease
-
批准号:10608277
-
项目类别:
-
资助金额:$43.69万
-
财政年份:2023
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular Carcinoma
-
批准号:10163812
-
项目类别:
-
资助金额:$28.33万
-
财政年份:2017
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular Carcinoma
-
批准号:9766108
-
项目类别:
-
资助金额:$26.25万
-
财政年份:2017
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular Carcinoma
-
批准号:10411391
-
项目类别:
-
资助金额:$5.93万
-
财政年份:2017
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Lipocalin 2 Inflammatory Bowel Disease
-
批准号:8726982
-
项目类别:
-
资助金额:$29.9万
-
财政年份:2013
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Lipocalin 2 Inflammatory Bowel Disease
-
批准号:8577770
-
项目类别:
-
资助金额:$29.9万
-
财政年份:2013
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
-
批准号:8459998
-
项目类别:
-
资助金额:$0.66万
-
财政年份:2012
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
-
批准号:8278779
-
项目类别:
-
资助金额:$7.34万
-
财政年份:2012
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
-
批准号:8776093
-
项目类别:
-
资助金额:$6.58万
-
财政年份:2012
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
-
批准号:8370147
-
项目类别:
-
资助金额:$12.8万
-
财政年份:2009
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
-
批准号:7786232
-
项目类别:
-
资助金额:$12.51万
-
财政年份:2009
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
-
批准号:7636186
-
项目类别:
-
资助金额:$11.88万
-
财政年份:2009
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
-
批准号:8324660
-
项目类别:
-
资助金额:$11.23万
-
财政年份:2009
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
-
批准号:8478091
-
项目类别:
-
资助金额:$2.43万
-
财政年份:2009
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
Role of Adaptive Immunity in the Development of Colitis in TLR5 Deficient Mice
-
批准号:8820427
-
项目类别:
-
资助金额:$9.58万
-
财政年份:2009
-
负责人:MATAM VIJAY-KUMAR
-
依托单位:
海外基金