Midcareer Investigator Award in Patient-Oriented Research

以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 9235244
• 负责人: ERIKA M D'AGATA
• 金额: $ 17.72万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9235244
• 关键词: Area; Award; Caliber; Centers for Disease Control and Prevention (U.S.); Chronic; Communicable Diseases; Development; Dialysis procedure; Discipline; Educational Status; Environment; Faculty; Foundations; Funding; Genotype; Geriatrics; Goals; Grant; Growth; Hemodialysis; Individual; Institution; Journals; Learning; Letters; Long-Term Care; Mathematics; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Nephrology; Outpatients; Patients; Pilot Projects; Population; Positioning Attribute; Prevention strategy; Principal Investigator; Public Health Schools; Publishing; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Resources; Risk; Science; Secure; Structure; Time; Training; Training Programs; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; antimicrobial; career; cohort; disorder prevention; interest; mathematical model; microbial; microbiome; multi-drug resistant pathogen; next generation sequencing; novel; patient oriented research; programs; public health relevance; skills; success; transmission process

 DESCRIPTION (provided by applicant): My career goals are to continue as an investigator in patient-oriented research (POR) and to provide mentoring for beginning investigators. My research focuses on the transmission dynamics of multidrug-resistant organisms (MDRO) among hospitalized patients, residents of long term care facilities, and the chronic hemodialysis population. My research has identified key and novel aspects of MDRO transmission and has quantified the most effective prevention strategies aimed at reducing their spread. Methodologies of my POR include large cohort and randomized controlled trials, genotyping of MDRO strains and mathematical modeling. Over the past years, I have built a successful independent research program and have secured National Institute of Health (NIH), Centers for Disease Control and Prevention, and National Science Foundation funding. I have also mentored numerous fellows and junior faculty, who under my mentorship, have obtained their own funding, published in leading journals and have gone on to become independent investigators and obtain academic faculty positions. Since my research crosses several disciplines, I have mentored trainees in a variety of subspecialties, including infectious diseases nephrology, geriatrics and mathematics. This is an optimal time in my career for a K24 award as I have an active research program that focuses on the development and implementation of antimicrobial stewardship programs in long term care facilities and out-patient dialysis units. This research will allow me to provide ample opportunities for trainees to perform research. I have also recently expanded my research area to the analyses of the microbiome and the identification of specific microbial signatures that increase the risk of MDRO acquisition, and have recently submitted an R01 with Dr. Martin Blaser (co-principal investigator), who is dedicated to providing his senior mentorship in this new area of my research. The K24 will allow me the time required to dedicate myself to learning this new field, and the ongoing growth of my research agenda. Lastly, this K24 will also allow me to have protected time to dedicate to the mentoring of trainees, a key component to successful mentoring.