Midcareer Investigator Award in Patient-Oriented Research

以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 9108690
• 负责人: ERIKA M D'AGATA
• 金额: $ 17.65万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108690
• 关键词: Area; Award; Caliber; Centers for Disease Control and Prevention (U.S.); Chronic; Communicable Diseases; Development; Dialysis procedure; Discipline; Educational Status; Environment; Faculty; Foundations; Funding; Genotype; Geriatrics; Goals; Grant; Growth; Hemodialysis; Individual; Institution; Journals; Learning; Letters; Long-Term Care; Mathematics; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Nephrology; Organism Strains; Outpatients; Patients; Pilot Projects; Population; Positioning Attribute; Prevention strategy; Principal Investigator; Public Health Schools; Publishing; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Resources; Risk; Science; Secure; Structure; Time; Training; Training Programs; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; antimicrobial; career; cohort; disorder prevention; interest; mathematical model; microbial; microbiome; multi-drug resistant pathogen; next generation sequencing; novel; patient oriented research; programs; public health relevance; skills; success; transmission process

 DESCRIPTION (provided by applicant): My career goals are to continue as an investigator in patient-oriented research (POR) and to provide mentoring for beginning investigators. My research focuses on the transmission dynamics of multidrug-resistant organisms (MDRO) among hospitalized patients, residents of long term care facilities, and the chronic hemodialysis population. My research has identified key and novel aspects of MDRO transmission and has quantified the most effective prevention strategies aimed at reducing their spread. Methodologies of my POR include large cohort and randomized controlled trials, genotyping of MDRO strains and mathematical modeling. Over the past years, I have built a successful independent research program and have secured National Institute of Health (NIH), Centers for Disease Control and Prevention, and National Science Foundation funding. I have also mentored numerous fellows and junior faculty, who under my mentorship, have obtained their own funding, published in leading journals and have gone on to become independent investigators and obtain academic faculty positions. Since my research crosses several disciplines, I have mentored trainees in a variety of subspecialties, including infectious diseases nephrology, geriatrics and mathematics. This is an optimal time in my career for a K24 award as I have an active research program that focuses on the development and implementation of antimicrobial stewardship programs in long term care facilities and out-patient dialysis units. This research will allow me to provide ample opportunities for trainees to perform research. I have also recently expanded my research area to the analyses of the microbiome and the identification of specific microbial signatures that increase the risk of MDRO acquisition, and have recently submitted an R01 with Dr. Martin Blaser (co-principal investigator), who is dedicated to providing his senior mentorship in this new area of my research. The K24 will allow me the time required to dedicate myself to learning this new field, and the ongoing growth of my research agenda. Lastly, this K24 will also allow me to have protected time to dedicate to the mentoring of trainees, a key component to successful mentoring.

 描述(由申请者提供)：我的职业目标是继续在以患者为中心的研究(POR)中担任调查员，并为初级调查人员提供指导。我的研究重点是多药耐药菌(MDRO)在住院患者、长期护理机构的居民和慢性血液透析人群中的传播动态。我的研究确定了MDRO传播的关键和新颖方面，并量化了旨在减少其传播的最有效的预防战略。My POR的方法包括大型队列和随机对照试验、MDRO菌株的基因分型和数学建模。在过去的几年里，我成功地建立了一个独立的研究项目，并获得了美国国立卫生研究院(NIH)、疾病控制和预防中心以及国家科学基金会的资助。我还指导了许多研究员和初级教员，在我的指导下，他们获得了自己的资金，在领先的期刊上发表文章，后来成为独立调查人员，并获得了学术教职。因为我的研究跨越了几个学科，我指导过各种子专业的受训人员，包括传染病肾病、老年病学和数学。这是我职业生涯中获得K24奖的最佳时机，因为我有一个积极的研究计划，专注于长期护理设施和门诊透析单位抗菌药物管理计划的开发和实施。这项研究将使我能够为学员提供充足的研究机会。我最近还将我的研究范围扩大到对微生物组的分析和对增加MDRO获取风险的特定微生物签名的识别，最近与马丁·布拉泽博士(联席首席研究员)提交了一份R01，他致力于在我的这一新研究领域提供他的高级导师。K24将给我所需的时间来致力于学习这个新领域，以及我的研究议程的持续增长。最后，这款K24还将让我有足够的时间致力于学员的指导，这是成功指导的关键组成部分。