Midcareer Investigator Award in Patient-Oriented Research

 描述（由申请人提供）：我的职业目标是继续作为一个以病人为导向的研究（POR）的调查员，并为开始的调查员提供指导。我的研究重点是多药耐药微生物（MDRO）在住院患者，长期护理机构的居民和慢性血液透析人群中的传播动力学。我的研究已经确定了MDRO传播的关键和新方面，并量化了旨在减少其传播的最有效的预防策略。我的POR方法包括大队列和随机对照试验，MDRO菌株的基因分型和数学建模。在过去的几年里，我建立了一个成功的独立研究项目，并获得了美国国家卫生研究院（NIH）、疾病控制和预防中心以及国家科学基金会的资助。我还指导了许多研究员和初级教师，在我的指导下，他们获得了自己的资金，在领先的期刊上发表文章，并成为独立的调查人员并获得学术教师职位。由于我的研究跨越多个学科，我指导过各种亚专业的学员，包括传染病肾病学、老年病学和数学。 这是我职业生涯中获得K24奖项的最佳时机，因为我有一个积极的研究计划，专注于长期护理机构和门诊透析单位抗菌管理计划的开发和实施。这项研究将使我能够为学员提供充分的机会进行研究。我最近还将我的研究领域扩展到微生物组的分析和增加MDRO获得风险的特定微生物特征的识别，并且最近与Martin Blaser博士（联合首席研究员）一起提交了R01，他致力于在我的研究的这个新领域提供他的高级指导。K24将使我有时间致力于学习这个新领域，以及我的研究议程的持续增长。最后，这个K24还将使我有受保护的时间致力于指导学员，这是成功指导的关键组成部分。

 DESCRIPTION (provided by applicant): My career goals are to continue as an investigator in patient-oriented research (POR) and to provide mentoring for beginning investigators. My research focuses on the transmission dynamics of multidrug-resistant organisms (MDRO) among hospitalized patients, residents of long term care facilities, and the chronic hemodialysis population. My research has identified key and novel aspects of MDRO transmission and has quantified the most effective prevention strategies aimed at reducing their spread. Methodologies of my POR include large cohort and randomized controlled trials, genotyping of MDRO strains and mathematical modeling. Over the past years, I have built a successful independent research program and have secured National Institute of Health (NIH), Centers for Disease Control and Prevention, and National Science Foundation funding. I have also mentored numerous fellows and junior faculty, who under my mentorship, have obtained their own funding, published in leading journals and have gone on to become independent investigators and obtain academic faculty positions. Since my research crosses several disciplines, I have mentored trainees in a variety of subspecialties, including infectious diseases nephrology, geriatrics and mathematics. This is an optimal time in my career for a K24 award as I have an active research program that focuses on the development and implementation of antimicrobial stewardship programs in long term care facilities and out-patient dialysis units. This research will allow me to provide ample opportunities for trainees to perform research. I have also recently expanded my research area to the analyses of the microbiome and the identification of specific microbial signatures that increase the risk of MDRO acquisition, and have recently submitted an R01 with Dr. Martin Blaser (co-principal investigator), who is dedicated to providing his senior mentorship in this new area of my research. The K24 will allow me the time required to dedicate myself to learning this new field, and the ongoing growth of my research agenda. Lastly, this K24 will also allow me to have protected time to dedicate to the mentoring of trainees, a key component to successful mentoring.