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COBRE Center for Antimicrobial Resistance and Therapeutic Discovery

COBRE Center for Antimicrobial Resistance and Therapeutic Discovery
COBRE 抗菌素耐药性和治疗发现中心
批准号:
10488596
负责人:
ERIKA M D'AGATA
金额:
$183.2万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-18 至 2024-07-31

项目摘要

项目成果

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中文摘要
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项目总结:
英文摘要
Project Summary: Overall Resistance to antimicrobial therapies is a national and international crisis that threatens clinical practice from fundamental primary care to the most advanced medical interventions such as cancer chemotherapy and organ transplantation. Much of what we take for granted in clinical medicine could become too risky as microorganisms have become increasingly resistant to our newest medications and our antibiotics of last resort. Antimicrobial resistance also adds enormous costs to health care, exceeding $21 billion in the United States alone. Compounding this problem is the fact that pharmaceutical companies have largely abandoned antibiotic development programs. As an alternative to large pharmaceutical companies, academic institutions and biotech startups can step in to refill the antibiotic pipeline using novel approaches to drug discovery. The principal objective of this Phase I COBRE application is to build a unique, multi-disciplinary center of excellence to study mechanisms of antimicrobial resistance and develop therapeutic countermeasures. The long-term goal of the Center for Antimicrobial Resistance and Therapeutic Discovery (CARTD) at The Miriam Hospital of the Lifespan Hospital Group is to develop new therapies for infections caused by drug resistant pathogens. This long-term goal will be attained with shorter-term objectives of developing a new generation of junior investigators who study mechanisms of resistance, characterize new targets, and study new and existing compounds. CARTD will integrate their work with mentors and established investigators at the institution and develop core facilities to enhance research capabilities in the field of antimicrobial resistance and the discovery of new therapeutics. To achieve these objectives, the CARTD will complete the following specific aims: 1. Consolidate existing researchers into a dynamic, interactive center of excellence across The Miriam Hospital, and its academic partners in Rhode Island, including Brown University. 2. Foster the research programs and career development of junior investigators in the field of antimicrobial resistance and studies of novel therapeutic approaches. 3. Support new institutional research with pilot project funding. 4. Establish critical infrastructure with new core laboratories to facilitate cutting edge research in antimicrobial resistance and therapeutic discovery, and serve as a unique technical resources to other COBRE research programs, other institutional researchers, and investigators in the region.
期刊论文(18)
专著(0)
科研奖励(0)
会议论文
DOI: 10.3390/antibiotics11081085
发表时间: 2022-08-10
期刊: Antibiotics (Basel, Switzerland)
影响因子: --
作者: []
通讯作者:
DOI: 10.3389/fimmu.2021.626798
发表时间: 2021
期刊: Frontiers in immunology
影响因子: 7.3
作者: [Schmitz NA, Thakare RP, Chung CS, Lee CM, Elias JA, Lee CG, LeBlanc BW]
通讯作者: LeBlanc BW
Novel Cecropin-4 Derived Peptides against Methicillin-Resistant Staphylococcus aureus.
新型天蚕素 4 衍生肽对抗耐甲氧西林金黄色葡萄球菌
DOI: 10.3390/antibiotics10010036
发表时间: 2021-01-01
期刊: Antibiotics (Basel, Switzerland)
影响因子: --
作者: [Peng J, Mishra B, Khader R, Felix L, Mylonakis E]
通讯作者: Mylonakis E
DOI: 10.1080/14656566.2021.1873951
发表时间: 2021-05
期刊: Expert opinion on pharmacotherapy
影响因子: 3.2
作者: [Scorzoni L, Fuchs BB, Junqueira JC, Mylonakis E]
通讯作者: Mylonakis E
9
    The INFECTADO study: INFECTions Acquired by persons on maintenance hemoDialysis during hOspitalizations
    • 批准号:
      10731626
    • 项目类别:
    • 资助金额:
      $50.0万
    • 财政年份:
      2023
    • 负责人:
      ERIKA M D'AGATA
    • 依托单位:
    Optimizing Antimicrobial Use in Maintenance Dialysis Units (OPTIMUS)
    • 批准号:
      10161826
    • 项目类别:
    • 资助金额:
      $45.07万
    • 财政年份:
      2020
    • 负责人:
      ERIKA M D'AGATA
    • 依托单位:
    Optimizing Antimicrobial Use in Maintenance Dialysis Units (OPTIMUS)
    • 批准号:
      10641882
    • 项目类别:
    • 资助金额:
      $40.22万
    • 财政年份:
      2020
    • 负责人:
      ERIKA M D'AGATA
    • 依托单位:
    Optimizing Antimicrobial Use in Maintenance Dialysis Units (OPTIMUS)
    • 批准号:
      10436161
    • 项目类别:
    • 资助金额:
      $2.78万
    • 财政年份:
      2020
    • 负责人:
      ERIKA M D'AGATA
    • 依托单位:
    海外基金