权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Intervention to increase access to PEP to prevent HIV infection among Black MSM

增加获得 PEP 的机会以预防黑人 MSM 感染艾滋病毒的干预措施

基本信息

批准号：
9266363
负责人：
Victoria Frye
金额：
$ 21.08万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9266363
关键词：
AIDS prevention Address Adverse effects Advocate Affect African American Area Awareness Behavior Behavioral Bisexual Caring Centers for Disease Control and Prevention (U.S.)Characteristics Cities Clinical Research Communities Data Development Diffusion of Innovation Education Eligibility Determination Emotional Ensure Exposure to Focus Groups Gays Guidelines HIV HIV Infections HIV diagnosis HIV/STD Health Health Services Homophobia Hour Human immunodeficiency virus test Incidence Individual Infection Infection prevention Insurance Coverage Intervention Interview Link Media Campaign Methods Modeling Motivation New York City Newly Diagnosed Outcome Participant Patients Pharmaceutical Preparations Phase Planning Theory Prevention Prevention strategy Printed Media Prophylactic treatment Provider Psychosocial Factor Qualitative Research Reporting Research Risk Site Social Environment Standardization Surveys Time Training Translating United States aged base black men who have sex with men burden of illness clinical care cost cost effective disorder prevention experience follow-up high risk high risk men improved member men who have sex with men metropolitan multi-component intervention peer pre-exposure prophylaxis prevent public health relevance racial disparity racism response sex risk social social media social stigma standard of care therapy design transmission process treatment duration uptake young men who have sex with men

项目摘要

DESCRIPTION (provided by applicant): Black MSM in the US are affected by HIV at severely disproportionate rates. A key component of HIV prevention for communities at risk is increasing access to and uptake of biomedical HIV prevention, including pre- and post-exposure prophylaxis (PrEP/PEP). PEP is underutilized by those at risk for HIV acquisition after exposure, despite the fact that Centers for Disease Control and Prevention (CDC) issued the first PEP guidelines over 15 years ago. Numerous barriers to successful PEP treatment exist along the "PEP cascade" for Black MSM. Research on the PEP cascade and barriers is sparse, with almost none focused solely on Black MSM. Increasing access to and uptake of PEP among Black MSM has the potential to reduce racial disparities in HIV incidence. To address this gap, we propose to evaluate the acceptability and feasibility of a multi- component intervention designed to increase awareness of, demand for, and access to PEP among Black MSM at high risk of HIV infection. The intervention has three components: 1) a social media campaign to increase demand for PEP among Black MSM; 2) a 24-hour helpline to link patients to timely clinical care; and 3) a PEP advocate intervention, modeled on peer health navigation, to ensure medication access and sustain engagement. The research will involve three phases. In Phase 1, we will conduct formative research to inform the media campaign and the PEP advocate intervention. In Phase 2, we will translate the results of the formative research into optimal messaging across relevant social and print media and standardize the PEP advocate intervention. In Phase 3, to assess impact of the media campaign, we will evaluate social media metrics and calls to the helpline. To assess the acceptability, feasibility and preliminary impact of the PEP advocate intervention, we will survey the first 50 eligible helpline callers and all patients accessing PEP at the clinical study site at 1-week and 3-months post exposure to describe the following outcomes: PEP uptake and completion, PEP care engagement, incident HIV and STIs, HIV testing, PrEP use, sexual risk behavior, select psychosocial factors and receipt of health services.

描述（由申请人提供）：美国黑人男男性接触者感染艾滋病毒的比例严重不成比例。高危社区艾滋病毒预防的一个关键组成部分是增加艾滋病毒生物医学预防的可及性和采用率，包括暴露前和暴露后预防（PrEP/PEP）。尽管美国疾病控制与预防中心 (CDC) 在 15 年前发布了第一份 PEP 指南，但那些在接触后有感染 HIV 风险的人并未充分利用 PEP。黑人 MSM 的“PEP 级联”中存在许多成功 PEP 治疗的障碍。关于 PEP 级联和障碍的研究很少，几乎没有一个只关注黑人 MSM。增加黑人男男性接触者获得和接受 PEP 的机会有可能减少艾滋病毒发病率的种族差异。为了弥补这一差距，我们建议评估多成分干预措施的可接受性和可行性，该干预措施旨在提高艾滋病毒感染高危黑人 MSM 对 PEP 的认识、需求和获取机会。该干预措施由三个部分组成：1）社交媒体运动，以增加黑人 MSM 对 PEP 的需求； 2) 24 小时帮助热线，为患者提供及时的临床护理； 3) 以同伴健康导航为模型的 PEP 倡导干预，以确保药物获取和维持参与。该研究将分为三个阶段。在第一阶段，我们将进行形成性研究，为媒体活动和政治公众人物倡导干预提供信息。在第二阶段，我们将把形成性研究的结果转化为相关社交和印刷媒体上的最佳信息传递，并使 PEP 倡导干预标准化。在第三阶段，为了评估媒体活动的影响，我们将评估社交媒体指标和求助热线电话。为了评估 PEP 倡导干预的可接受性、可行性和初步影响，我们将调查前 50 名符合条件的求助热线呼叫者以及暴露后 1 周和 3 个月在临床研究中心访问 PEP 的所有患者，以描述以下结果：PEP 的接受和完成、PEP 护理参与度、HIV 和性传播感染事件、HIV 检测、PrEP 使用、性风险行为、选择心理社会因素和健康接受情况服务。