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Intervention to increase access to PEP to prevent HIV infection among Black MSM

增加获得 PEP 的机会以预防黑人 MSM 感染艾滋病毒的干预措施

基本信息

批准号：
9266363
负责人：
Victoria Frye
金额：
$ 21.08万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9266363
关键词：
AIDS prevention Address Adverse effects Advocate Affect African American Area Awareness Behavior Behavioral Bisexual Caring Centers for Disease Control and Prevention (U.S.)Characteristics Cities Clinical Research Communities Data Development Diffusion of Innovation Education Eligibility Determination Emotional Ensure Exposure to Focus Groups Gays Guidelines HIV HIV Infections HIV diagnosis HIV/STD Health Health Services Homophobia Hour Human immunodeficiency virus test Incidence Individual Infection Infection prevention Insurance Coverage Intervention Interview Link Media Campaign Methods Modeling Motivation New York City Newly Diagnosed Outcome Participant Patients Pharmaceutical Preparations Phase Planning Theory Prevention Prevention strategy Printed Media Prophylactic treatment Provider Psychosocial Factor Qualitative Research Reporting Research Risk Site Social Environment Standardization Surveys Time Training Translating United States aged base black men who have sex with men burden of illness clinical care cost cost effective disorder prevention experience follow-up high risk high risk men improved member men who have sex with men metropolitan multi-component intervention peer pre-exposure prophylaxis prevent public health relevance racial disparity racism response sex risk social social media social stigma standard of care therapy design transmission process treatment duration uptake young men who have sex with men

项目摘要

DESCRIPTION (provided by applicant): Black MSM in the US are affected by HIV at severely disproportionate rates. A key component of HIV prevention for communities at risk is increasing access to and uptake of biomedical HIV prevention, including pre- and post-exposure prophylaxis (PrEP/PEP). PEP is underutilized by those at risk for HIV acquisition after exposure, despite the fact that Centers for Disease Control and Prevention (CDC) issued the first PEP guidelines over 15 years ago. Numerous barriers to successful PEP treatment exist along the "PEP cascade" for Black MSM. Research on the PEP cascade and barriers is sparse, with almost none focused solely on Black MSM. Increasing access to and uptake of PEP among Black MSM has the potential to reduce racial disparities in HIV incidence. To address this gap, we propose to evaluate the acceptability and feasibility of a multi- component intervention designed to increase awareness of, demand for, and access to PEP among Black MSM at high risk of HIV infection. The intervention has three components: 1) a social media campaign to increase demand for PEP among Black MSM; 2) a 24-hour helpline to link patients to timely clinical care; and 3) a PEP advocate intervention, modeled on peer health navigation, to ensure medication access and sustain engagement. The research will involve three phases. In Phase 1, we will conduct formative research to inform the media campaign and the PEP advocate intervention. In Phase 2, we will translate the results of the formative research into optimal messaging across relevant social and print media and standardize the PEP advocate intervention. In Phase 3, to assess impact of the media campaign, we will evaluate social media metrics and calls to the helpline. To assess the acceptability, feasibility and preliminary impact of the PEP advocate intervention, we will survey the first 50 eligible helpline callers and all patients accessing PEP at the clinical study site at 1-week and 3-months post exposure to describe the following outcomes: PEP uptake and completion, PEP care engagement, incident HIV and STIs, HIV testing, PrEP use, sexual risk behavior, select psychosocial factors and receipt of health services.

描述（由申请人提供）：美国的黑人男男性行为者受艾滋病毒影响的比例严重不成比例。高危社区预防艾滋病毒的一个关键组成部分是增加获得和接受生物医学艾滋病毒预防，包括接触前和接触后预防。尽管疾病控制和预防中心（CDC）在15年前发布了第一个PEP指南，但暴露后有艾滋病毒感染风险的人没有充分利用PEP。许多障碍，以成功的PEP治疗存在沿着“PEP级联”的黑色男男性接触者。关于PEP级联和障碍的研究很少，几乎没有一个只关注黑人MSM。增加黑人男男性行为者获得和接受PEP的机会有可能减少艾滋病毒发病率的种族差异。为了解决这一差距，我们建议评估的可接受性和可行性的多组件干预措施，旨在提高认识，需求，并获得PEP之间的黑人男男性行为者在艾滋病毒感染的高风险。干预有三个组成部分：1）社交媒体活动，以增加黑人男同性恋者对PEP的需求; 2）24小时热线，将患者与及时的临床护理联系起来; 3）PEP倡导干预，以同伴健康导航为模型，以确保药物获得和持续参与。研究将分三个阶段进行。在第一阶段，我们将进行形成性研究，为媒体活动和PEP倡导者干预提供信息。在第二阶段，我们将把形成性研究的结果转化为相关社交媒体和印刷媒体的最佳信息传递，并将PEP倡导干预标准化。在第三阶段，为了评估媒体活动的影响，我们将评估社交媒体指标和对媒体的呼吁。为了评估PEP倡导者干预的可接受性、可行性和初步影响，我们将在暴露后1周和3个月在临床研究中心调查前50名合格的电话呼叫者和所有访问PEP的患者，以描述以下结局：PEP的吸收和完成，PEP护理参与，艾滋病毒和性传播感染事件，艾滋病毒检测，PrEP使用，性风险行为，选择心理社会因素和接受保健服务。