Molecular Dissection of Myoblast Fusion In Muscle Development and Regeneration

肌肉发育和再生中成肌细胞融合的分子解剖

基本信息

  • 批准号:
    9301471
  • 负责人:
  • 金额:
    $ 35.64万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-15 至 2020-06-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): The formation of skeletal muscle during embryonic development and following injury to adult muscle requires fusion of myoblasts to form multinucleated myofibers. Recently, we discovered a novel muscle-specific membrane protein, named Myomaker, that controls vertebrate myoblast fusion during embryogenesis and adulthood. Myomaker is expressed on the cell surface of embryonic myoblasts during fusion and is down- regulated thereafter. Similarly, Myomaker is up-regulated in muscle satellite cells in response to injury, concomitant with their fusion during muscle regeneration. Over-expression of Myomaker in myoblasts dramatically enhances fusion and forced expression in fibroblasts promotes fusion with myoblasts. Conversely, genetic disruption of Myomaker in mice causes perinatal death due to an absence of multi- nucleated muscle fibers and conditional gene deletion in adult satellite cells completely prevents muscle regeneration. The discovery of Myomaker provides a new inroad into myoblast fusion and will enable the detailed molecular dissection of the mechanistic basis of this process. Myomaker belongs to a small family of related membrane proteins that are expressed in other cell types, suggesting a general mechanism for cell-cell fusion. The goals of this project are to define the precise molecular mechanism whereby Myomaker drives myoblast fusion and to identify additional components of the process through which Myomaker exerts its fusogenic activity. The insights gleaned from these studies will shed light not only on the fundamental mechanisms of intercellular fusion but will also have important implications for understanding muscle disease and for the potential development of new therapeutic strategies for restoration of function to diseased muscle.


项目成果

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RHONDA BASSEL-DUBY其他文献

RHONDA BASSEL-DUBY的其他文献

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{{ truncateString('RHONDA BASSEL-DUBY', 18)}}的其他基金

Transcriptional Control of Neonatal Heart Regeneration
新生儿心脏再生的转录控制
  • 批准号:
    10534778
  • 财政年份:
    2021
  • 资助金额:
    $ 35.64万
  • 项目类别:
Transcriptional Control of Neonatal Heart Regeneration
新生儿心脏再生的转录控制
  • 批准号:
    10365703
  • 财政年份:
    2021
  • 资助金额:
    $ 35.64万
  • 项目类别:
Chemically assisted remodeling of infarcted heart tissue by targeting Wnt lipidation
通过靶向 Wnt 脂化化学辅助重塑梗塞心脏组织
  • 批准号:
    9364733
  • 财政年份:
    2017
  • 资助金额:
    $ 35.64万
  • 项目类别:
Deciphering the role of a novel micropeptide in cardiac function and dysfunction
破译新型微肽在心脏功能和功能障碍中的作用
  • 批准号:
    10331296
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:
Myoediting of Duchenne Muscular Dystrophy
杜氏肌营养不良症的肌编辑
  • 批准号:
    10684149
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:
Scientific Research Resource Core
科研资源核心
  • 批准号:
    10684164
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:
Scientific Research Resource Core
科研资源核心
  • 批准号:
    10261406
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:
Scientific Research Resource Core
科研资源核心
  • 批准号:
    10473540
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:
Myoediting of Duchenne Muscular Dystrophy
杜氏肌营养不良症的肌编辑
  • 批准号:
    10261402
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:
Deciphering the role of a novel micropeptide in cardiac function and dysfunction
破译新型微肽在心脏功能和功能障碍中的作用
  • 批准号:
    10089466
  • 财政年份:
    2015
  • 资助金额:
    $ 35.64万
  • 项目类别:

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