Long Term Supplementation with Retinyl Palmitate (Vitamin A) and the Risk of Bone Fractures: A population based study.

长期补充视黄醇棕榈酸酯（维生素 A）与骨折风险：一项基于人群的研究。

• 批准号: nhmrc : 458608
• 负责人: A/Pr Alison Reid
• 金额: $ 11.18万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/long-term-supplementation-based-study/81823
• 关键词: Long; Term; Supplementation; Retinyl; Palmitate

Osteoporosis is a major health problem in Australia and other western industrialised countries where populations are increasingly ageing. In Australia, the number of hip fractures is expected to increase by 36% between 1996 and 2006, owing to the rise in elderly aged 85 years and over. This is in contrast to projections in Europe and North America, where the number of hip fractures are expected to double by 2026 and then stabilise. Clarification of the role of vitamin A in bone health is pertinent, given that the popularity of supplement use has increased markedly in western industrialised countries over the past two decades. Around 37% of the adult population in Australia is thought to take a supplement regularly and figures range from 28% to 54% of adults in the US, with women and adults aged over 49 years being more likely to use supplements. Furthermore, the fortification of food with minerals and vitamins is increasing. For all of these reasons, is it imperative that the role of vitamin A in inducing fractures be clarified. Results from this study will contribute to knowledge about the safety of retinol and beta carotene supplements in relation to bone health, which is especially relevant to people at risk of osteoporosis, and people who take vitamin A supplements. We will also be able to clarify the upper levels of dietary retinol, beta carotene and vitamin A intake beyond which fracture risk increases. Because of the age range of subjects in our study, our results should be applicable to the whole population, not only the elderly or post menopausal. The results of our study will be useful to agencies such as Food Standards Australia and New Zealand which regulates our food supply.

骨质疏松症是澳大利亚和其他西方工业化国家的一个主要健康问题，人口日益老龄化。在澳大利亚，由于85岁及以上老年人的增加，髋部骨折的数量预计在1996年至2006年期间将增加36%。这与欧洲和北美的预测相反，预计到2026年，髋部骨折的数量将翻一番，然后稳定下来。澄清维生素A在骨骼健康中的作用是恰当的，因为在过去的二十年中，补充剂的使用在西方工业化国家显着增加。澳大利亚约有37%的成年人定期服用补充剂，美国成年人的比例从28%到54%不等，49岁以上的女性和成年人更有可能服用补充剂。此外，在食品中添加矿物质和维生素的情况也在增加。由于所有这些原因，必须澄清维生素A在诱导骨折中的作用。这项研究的结果将有助于了解视黄醇和β胡萝卜素补充剂与骨骼健康的安全性，这与骨质疏松症风险人群和服用维生素A补充剂的人群尤其相关。我们还将能够澄清饮食中视黄醇、β胡萝卜素和维生素A摄入量的上限，超过这个上限，骨折风险就会增加。由于我们研究受试者的年龄范围，我们的结果应适用于整个人群，而不仅仅是老年人或绝经后人群。我们的研究结果将有助于澳大利亚和新西兰等监管食品供应的机构。